Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2771
Official Symbol:GNAI2
Other Aliases:GIP|GNAI2B|H_LUCA15.1|H_LUCA16.1
See related:HGNC:4385|MIM:139360|HPRD:00764
Chromosome:3
Location:3p21
Gene Description:guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0007
ORGANISM:human
Entrez Gene ID:2771
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:14678
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2771GO:0000166IEAFunctionnucleotide binding
2771GO:0003924TASFunctionGTPase activity
2771GO:0004871IEAFunctionsignal transducer activity
2771GO:0005515IPIFunctionprotein binding
2771GO:0005525IEAFunctionGTP binding
2771GO:0007165IEAProcesssignal transduction
2771GO:0007165TASProcesssignal transduction
2771GO:0007186IEAProcessG-protein coupled receptor protein signaling pathway
2771GO:0007186TASProcessG-protein coupled receptor protein signaling pathway
2771GO:0007194TASProcessnegative regulation of adenylate cyclase activity
2771GO:0007584TASProcessresponse to nutrient
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3973NP_000224.1luteinizing hormone/choriogonadotropin receptor precursorHPRD01073
-3576NP_000575.1interleukin 8 precursorHPRD00909
-3577NP_000625.1interleukin 8 receptor alphaHPRD00908
-3480NP_000866.1insulin-like growth factor 1 receptor precursorHPRD00932
-4985NP_000902.2opioid receptor, delta 1HPRD01308
-4988NP_000905.1opioid receptor, mu 1HPRD02484
-8490NP_003608.1regulator of G-protein signalling 5HPRD04471
-5999NP_005604.1regulator of G-protein signaling 4HPRD03947
-10287NP_005864.1G protein signalling regulator 19HPRD05461
-4543NP_005949.1melatonin receptor 1AHPRD02812
-4924NP_006175.2nucleobindin 1HPRD03205
-10636NP_006471.2regulator of G-protein signalling 14HPRD03944
-29899NP_037428.2G-protein signalling modulator 2 (AGS3-like, C. elegans)HPRD06609
-60626NP_068751.4resistance to inhibitors of cholinesterase 8 homolog AHPRD12373
-64805NP_073625.1purinergic receptor P2Y12HPRD02743
-64407NP_570138.1regulator of G-protein signalling 18HPRD06224
-6002NP_937872.1regulator of G-protein signalling 12 isoform 1HPRD03943
NP_002061.1--Galanin receptorHPRD00764
NP_002061.1--Adenyl cyclaseHPRD00764
NP_002061.1--Alpha 2C10 adrenoceptorHPRD00764
NP_002061.1--Thrombin receptorsHPRD00764
NP_002061.14985-Opioid receptorHPRD00764
NP_002061.164805-Purinergic receptor P2Y, G protein coupled 12HPRD00764
NP_002061.13576-Interleukin 8HPRD00764
NP_002061.13577-Interleukin 8 receptor, alphaHPRD00764
NP_002061.129899-LGN proteinHPRD00764
NP_002061.110287-Regulator of G protein signaling 19HPRD00764
NP_002061.18490-Regulator of G protein signaling 5HPRD00764
NP_002061.14924-Nucleobindin 1HPRD00764
NP_002061.15999-Regulator of G protein signaling 4HPRD00764
NP_002061.13973-Luteinizing hormone/choriogonadotropin receptorHPRD00764
NP_002061.14543-Melatonin receptor 1AHPRD00764
NP_002061.13480-IGF-I receptorHPRD00764
NP_002061.110636-Regulator of G protein signaling 14HPRD00764
NP_002061.16002-Regulator of G protein signaling 12HPRD00764
NP_002061.164407-Regulator of G protein signaling 18HPRD00764
NP_002061.14988-Opioid receptor mu 1HPRD00764
NP_002061.17265NP_003305.1tetratricopeptide repeat domain 1HPRD11881
NP_002061.123566NP_036284.1endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7HPRD00764
NP_002061.123566NP_036284.1endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7HPRD05486
NP_002061.151655NP_057168.1RAS, dexamethasone-induced 1HPRD00764
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2771GNAI2_HUMANP04899IPR002975Fungi_GproteinAFungal G-protein, alpha subunit
2771GNAI2_HUMANP04899IPR000367Gprotein_alpha_SG-protein alpha subunit, group S
2771GNAI2_HUMANP04899IPR000469Gprotein_alpha12G-protein alpha subunit, group 12
2771GNAI2_HUMANP04899IPR001019Gprotein_alph_bdGuanine nucleotide binding protein (G-protein), alpha subunit
2771GNAI2_HUMANP04899IPR001408Gprotein_alpha_IG-protein alpha subunit, group I
2771GNAI2_HUMANP04899IPR001806Ras_trnsfrmngRas GTPase

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