Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2775
Official Symbol:GNAO1
Other Aliases:DKFZp686O0962|G-ALPHA-o|GNAO
See related:HGNC:4389|MIM:139311|HPRD:00757
Chromosome:16
Location:16q13
Gene Description:guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0348
ORGANISM:human
Entrez Gene ID:2775
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:14681
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0586
ORGANISM:human
Entrez Gene ID:2775
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:50664
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:EVIM0123
ORGANISM:human
Entrez Gene ID:2775
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:4.99 :: 4.62 :: 1.84 :: -0.06 :: -3.64 :: -5.13 :: -2.15
KARG Evidence 4
KARG ID:QTL0128
ORGANISM:human
Entrez Gene ID:2775
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14681CBCerebellum42.748481114705472.147518157959
14681CTXCerebral cortex58.560357411702553.1558272043864
14681HIPHippocampal region65.592127482096472.1886901855469
14681HPFHippocampal formation63.648704528808664.7669448852539
14681HYHypothalamus40.638359387715738.6340564092
14681LSXLateral septal complex36.868992408116735.339647491773
14681MBMidbrain38.428821563720737.4803163210551
14681MYMedulla38.923523902893139.9548563957214
14681OLFOlfactory bulb63.149291992187553.1034603118896
14681PPons39.104048728942939.097779750824
14681PALPallidum41.433778444925941.2887996037801
14681RHPRetrohippocampal region61.892843882242856.3828830718994
14681sAMYStriatum-like amygdalar nuclei51.055146535237645.6874504089355
14681STRStriatum57.404628117879249.4540227254232
14681STRdStriatum dorsal region62.65277989705453.3823184967041
14681STRvStriatum ventral region50.686741193135643.7463674545288
14681THThalamus41.362703323364339.3612804412842
KARG Evidence 5
KARG ID:QTL0128
Trait:METH responses for body temperature
Peak:45
Peak Marker:D8Ncvs43
Parents:C57BL/6J x DBA/2J intercross
Evidence ID:8987796
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2775GO:0000166IEAFunctionnucleotide binding
2775GO:0003924TASFunctionGTPase activity
2775GO:0005057NRFunctionreceptor signaling protein activity
2775GO:0005525IEAFunctionGTP binding
2775GO:0006936TASProcessmuscle contraction
2775GO:0007165IEAProcesssignal transduction
2775GO:0007186IEAProcessG-protein coupled receptor protein signaling pathway
2775GO:0007399NRProcessnervous system development
2775GO:0007411NRProcessaxon guidance
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3355NP_000857.15-hydroxytryptamine (serotonin) receptor 1FHPRD01637
-4985NP_000902.2opioid receptor, delta 1HPRD01308
-4988NP_000905.1opioid receptor, mu 1HPRD02484
-8490NP_003608.1regulator of G-protein signalling 5HPRD04471
-2867NP_005297.1G protein-coupled receptor 43HPRD04824
-5999NP_005604.1regulator of G-protein signaling 4HPRD03947
-10287NP_005864.1G protein signalling regulator 19HPRD05461
-10636NP_006471.2regulator of G-protein signalling 14HPRD03944
-29899NP_037428.2G-protein signalling modulator 2 (AGS3-like, C. elegans)HPRD06609
-59340NP_067637.2histamine H4 receptorHPRD06004
-60626NP_068751.4resistance to inhibitors of cholinesterase 8 homolog AHPRD12373
-53637NP_110387.1endothelial differentiation, sphingolipid G-protein-coupled receptor, 8HPRD05510
NP_066268.1--Go-betaHPRD00757
NP_066268.1--Go-gammaHPRD00757
NP_066268.1--RGS(retinal)HPRD00757
NP_066268.14985-Opioid receptorHPRD00757
NP_066268.14988-Opioid receptor mu 1HPRD00757
NP_066268.110287-Regulator of G protein signaling 19HPRD00757
NP_066268.18490-Regulator of G protein signaling 5HPRD00757
NP_066268.15999-Regulator of G protein signaling 4HPRD00757
NP_066268.110636-Regulator of G protein signaling 14HPRD00757
NP_066268.159340-Histamine H4 receptorHPRD00757
NP_066268.153637-Endothelial differentiation gene 8HPRD00757
NP_066268.13355-Serotonin 5 HT 1F receptorHPRD00757
NP_066268.129899-LGN proteinHPRD00757
NP_066268.16000NP_002915.2regulator of G-protein signalling 7HPRD00757
NP_066268.16000NP_002915.2regulator of G-protein signalling 7HPRD03948
NP_066268.12867NP_005297.1G protein-coupled receptor 43HPRD00757
NP_066268.110076NP_005695.2protein tyrosine phosphatase, receptor type, U isoform 3 precursorHPRD03908
NP_066268.16334NP_055006.1sodium channel, voltage gated, type VIII, alphaHPRD09006
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2775GNAO1_HUMANP09471IPR002975Fungi_GproteinAFungal G-protein, alpha subunit
2775GNAO1_HUMANP09471IPR001019Gprotein_alph_bdGuanine nucleotide binding protein (G-protein), alpha subunit
2775GNAO1_HUMANP09471IPR001408Gprotein_alpha_IG-protein alpha subunit, group I
2775GNAO1_HUMANP09471IPR001806Ras_trnsfrmngRas GTPase
2775GNAO2_HUMANP29777IPR002975Fungi_GproteinAFungal G-protein, alpha subunit
2775GNAO2_HUMANP29777IPR001019Gprotein_alph_bdGuanine nucleotide binding protein (G-protein), alpha subunit
2775GNAO2_HUMANP29777IPR001408Gprotein_alpha_IG-protein alpha subunit, group I
2775GNAO2_HUMANP29777IPR001806Ras_trnsfrmngRas GTPase

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