Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2776
Official Symbol:GNAQ
Other Aliases:G-ALPHA-q|GAQ
See related:HGNC:4390|MIM:600998|HPRD:02998
Chromosome:9
Location:9q21
Gene Description:guanine nucleotide binding protein (G protein), q polypeptide
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0573
ORGANISM:human
Entrez Gene ID:2776
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:81666
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:QTL0251
ORGANISM:human
Entrez Gene ID:2776
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14682CBCerebellum40.109016418457100.0
14682CTXCerebral cortex100.0100.0
14682HIPHippocampal region100.0100.0
14682HPFHippocampal formation100.0100.0
14682HYHypothalamus60.43853378295954.0131568908691
14682LSXLateral septal complex80.206993103027373.3535461425781
14682MBMidbrain59.877960205078160.9925994873047
14682MYMedulla62.047096252441474.1123428344727
14682OLFOlfactory bulb88.893692016601699.9042663574219
14682PPons53.814537048339860.5539512634277
14682PALPallidum59.703247070312561.5955467224121
14682RHPRetrohippocampal region100.0100.0
14682sAMYStriatum-like amygdalar nuclei96.082054138183686.2975234985352
14682STRStriatum56.955287933349648.5057411193848
14682STRdStriatum dorsal region46.00505447387739.2773895263672
14682STRvStriatum ventral region63.351268768310547.947509765625
14682THThalamus67.305259704589863.7837715148926
KARG Evidence 3
KARG ID:QTL0251
Trait:METH responses for body temperature
Peak:9
Peak Marker:Pomc-2
Parents:C57BL/6J x DBA/2J intercross
Evidence ID:8987796
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2776GO:0000166IEAFunctionnucleotide binding
2776GO:0003924TASFunctionGTPase activity
2776GO:0004871IEAFunctionsignal transducer activity
2776GO:0005525IEAFunctionGTP binding
2776GO:0005737TASComponentcytoplasm
2776GO:0005834NRComponentheterotrimeric G-protein complex
2776GO:0005886TASComponentplasma membrane
2776GO:0006471IEAProcessprotein amino acid ADP-ribosylation
2776GO:0007165IEAProcesssignal transduction
2776GO:0007186IEAProcessG-protein coupled receptor protein signaling pathway
2776GO:0007202TASProcessphospholipase C activation
2776GO:0007596TASProcessblood coagulation
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7433CAA53046.1intestinal VIP (Vasoactive intestinal peptide) receptorHPRD01890
-3356NP_000612.15-hydroxytryptamine (serotonin) receptor 2AHPRD01638
-2912NP_000830.1glutamate receptor, metabotropic 2 precursorHPRD04977
-2914NP_000832.1glutamate receptor, metabotropic 4HPRD04978
-3357NP_000858.15-hydroxytryptamine (serotonin) receptor 2BHPRD03077
-5739NP_000951.1prostaglandin I2 (prostacyclin) receptor (IP)HPRD08959
-5997NP_002914.1regulator of G-protein signalling 2, 24kDaHPRD02917
-6000NP_002915.2regulator of G-protein signalling 7HPRD03948
-8490NP_003608.1regulator of G-protein signalling 5HPRD04471
-9294NP_004221.1endothelial differentiation, sphingolipid G-protein-coupled receptor, 5HPRD05488
-9368NP_004243.1solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1HPRD05406
-5330NP_004564.1phospholipase C, beta 2HPRD04985
-2867NP_005297.1G protein-coupled receptor 43HPRD04824
-5999NP_005604.1regulator of G-protein signaling 4HPRD03947
-11214NP_006729.4A-kinase anchor protein 13 isoform 1HPRD05253
-64407NP_570138.1regulator of G-protein signalling 18HPRD06224
-2917NP_870989.1glutamate receptor, metabotropic 7 isoform b precursorHPRD04979
NP_002063.1--Prostacyclin receptorHPRD02998
NP_002063.12912-Metabotropic glutamate receptor 2HPRD02998
NP_002063.12914-Metabotropic glutamate receptor 4HPRD02998
NP_002063.15997-RGS2HPRD02998
NP_002063.15999-Regulator of G protein signaling 4HPRD02998
NP_002063.15739-Prostacyclin receptorHPRD02998
NP_002063.19294-Endothelial differentiation gene 5HPRD02998
NP_002063.12917-Metabotropic glutamate receptor 7HPRD02998
NP_002063.18490-Regulator of G protein signaling 5HPRD02998
NP_002063.111214-A kinase anchoring protein 13HPRD02998
NP_002063.15330-Phospholipase C, beta 2HPRD02998
NP_002063.17433-Vasoactive intestinal peptide receptor 1HPRD02998
NP_002063.13356-Serotonin 5-HT-2A receptorHPRD02998
NP_002063.13357-5 hydroxytryptamine receptor 2BHPRD02998
NP_002063.164407-Regulator of G protein signaling 18HPRD02998
NP_002063.19368-Solute carrier family 9, isoform A3, regulatory factor 1HPRD02998
NP_002063.16000-Regulator of G protein signaling 7HPRD02998
NP_002063.12867-GPR43HPRD02998
NP_002063.17253NP_000360.1thyroid stimulating hormone receptorHPRD04537
NP_002063.17253NP_000360.1thyroid stimulating hormone receptorHPRD02998
NP_002063.17265NP_003305.1tetratricopeptide repeat domain 1HPRD11881
NP_002063.18811NP_003848.1galanin receptor 2HPRD02998
NP_002063.18811NP_003848.1galanin receptor 2HPRD04735
NP_002063.12864NP_005294.1G protein-coupled receptor 40HPRD02998
NP_002063.12864NP_005294.1G protein-coupled receptor 40HPRD04822
NP_002063.15290NP_006209.1phosphoinositide-3-kinase, catalytic, alpha polypeptideHPRD02998
NP_002063.123236NP_056007.1phosphoinositide-specific phospholipase C beta 1 isoform aHPRD02998
NP_002063.123236NP_056007.1phosphoinositide-specific phospholipase C beta 1 isoform aHPRD06177
NP_002063.155188NP_060627.1resistance to inhibitors of cholinesterase 8 homolog BHPRD16452
NP_002063.160626NP_068751.4resistance to inhibitors of cholinesterase 8 homolog AHPRD12373
NP_002063.16915NP_963998.1thromboxane A2 receptor isoform 2HPRD01768
NP_002063.16915NP_963998.1thromboxane A2 receptor isoform 2HPRD02998
NP_002063.2---BIND257796
NP_002063.27265NP_003305.1tetratricopeptide repeat domain 1BIND134471
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2776GNAQ_HUMANP50148IPR002975Fungi_GproteinAFungal G-protein, alpha subunit
2776GNAQ_HUMANP50148IPR000469Gprotein_alpha12G-protein alpha subunit, group 12
2776GNAQ_HUMANP50148IPR000654Gprotein_alpha_QG-protein alpha subunit, group Q
2776GNAQ_HUMANP50148IPR001019Gprotein_alph_bdGuanine nucleotide binding protein (G-protein), alpha subunit
2776GNAQ_HUMANP50148IPR001408Gprotein_alpha_IG-protein alpha subunit, group I

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