Knowledgebase for Addiction-Related Genes
Home | Score | Chromosome | Pathway | Advanced Search | BLAST Search | Downloads | Publications | FAQ & Help |   

KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2782
Official Symbol:GNB1
Other Aliases:-
See related:HGNC:4396|MIM:139380|HPRD:00766
Chromosome:1
Location:1p36.33
Gene Description:guanine nucleotide binding protein (G protein), beta polypeptide 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0564
ORGANISM:human
Entrez Gene ID:2782
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:24400
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0124
ORGANISM:human
Entrez Gene ID:2782
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:-0.35 :: 1.27 :: 1.70 :: 1.42 :: -1.17 :: -0.80 :: -3.25
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14688CBCerebellum8.6142311096191414.2806606292725
14688CTXCerebral cortex50.050.0
14688HIPHippocampal region45.33464431762750.0
14688HPFHippocampal formation50.050.0
14688HYHypothalamus15.031562805175816.8815841674805
14688LSXLateral septal complex26.911746978759826.6428604125977
14688MBMidbrain13.024159431457517.1413269042969
14688MYMedulla8.5208759307861314.5801887512207
14688OLFOlfactory bulb46.485588073730550.0
14688PPons10.974924087524418.4096508026123
14688PALPallidum23.469432830810528.2489929199219
14688RHPRetrohippocampal region50.050.0
14688sAMYStriatum-like amygdalar nuclei33.883384704589832.9710006713867
14688STRStriatum32.333972930908229.76735496521
14688STRdStriatum dorsal region33.067546844482430.3994197845459
14688STRvStriatum ventral region32.533946990966828.3239059448242
14688THThalamus33.164554595947338.7037353515625
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2782GO:0004871IEAFunctionsignal transducer activity
2782GO:0007165IEAProcesssignal transduction
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-2786NP_004476.1guanine nucleotide binding protein (G protein), gamma 4HPRD11978
-2785NP_036334.1guanine nucleotide binding protein (G protein), gamma 3HPRD12337
-2788NP_443079.1guanine nucleotide binding protein (G protein), gamma 7HPRD10376
-54331NP_444292.1guanine nucleotide binding protein (G protein), gamma 2HPRD16234
NP_002065.1--GNG2HPRD00766
NP_002065.1--GNG3HPRD00766
NP_002065.110399-RACK1HPRD00766
NP_002065.1548645AAH48318.1BA16L21.2.1 proteinHPRD10374
NP_002065.12791NP_004117.1guanine nucleotide binding protein gamma 11 precursorHPRD11979
NP_002065.15082NP_005379.2phosducin-likeBIND297474
NP_002065.123370NP_056133.2Rho-specific guanine nucleotide exchange factor p114HPRD12479
NP_002065.151764NP_057625.1guanine nucleotide binding protein (G protein), gamma 13HPRD12116
NP_002065.154331NP_444292.1guanine nucleotide binding protein (G protein), gamma 2BIND215361
NP_002065.154331NP_444292.1guanine nucleotide binding protein (G protein), gamma 2BIND297473
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2782GBB1_HUMANP62873IPR001632Gprotein_BG-protein, beta subunit
2782GBB1_HUMANP62873IPR013577LLGL2Lethal giant larvae homologue 2
2782GBB1_HUMANP62873IPR001680WD40WD-40 repeat

© Center for Bioinformatics(CBI), Peking University
Any Comments and suggestions to : KARG GROUP.