Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2824
Official Symbol:GPM6B
Other Aliases:M6B|MGC17150|MGC54284
See related:HGNC:4461|MIM:300051|HPRD:02082
Chromosome:X
Location:Xp22.2
Gene Description:glycoprotein M6B
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0131
ORGANISM:human
Entrez Gene ID:2824
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:3.84 :: 2.82 :: 1.90 :: 1.09 :: -2.23 :: -3.94 :: 0.28
KARG Evidence 2
KARG ID:EVIM0390
ORGANISM:human
Entrez Gene ID:2824
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.3 :: -1.2 :: 1.2 :: 1.6 :: 1.3 :: 1.5
KARG Evidence 3
KARG ID:EVIM0458
ORGANISM:human
Entrez Gene ID:2824
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Upregulated
Fold Change:1.1 :: 1.1 :: 1.5 :: 3.1 :: 1.5
KARG Evidence 4
KARG ID:EVIM0814
ORGANISM:human
Entrez Gene ID:2824
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.6 :: -1.5
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14758CBCerebellum82.6200485229492100.0
14758CTXCerebral cortex100.0100.0
14758HIPHippocampal region100.0100.0
14758HPFHippocampal formation100.0100.0
14758HYHypothalamus88.256538391113371.1503620147705
14758LSXLateral septal complex100.0100.0
14758MBMidbrain100.099.1595993041992
14758MYMedulla100.0100.0
14758OLFOlfactory bulb100.0100.0
14758PPons100.0100.0
14758PALPallidum93.931205749511788.8672485351562
14758RHPRetrohippocampal region100.0100.0
14758sAMYStriatum-like amygdalar nuclei96.266819000244188.0691146850586
14758STRStriatum100.0100.0
14758STRdStriatum dorsal region100.0100.0
14758STRvStriatum ventral region100.0100.0
14758THThalamus95.476463317871187.4201393127441
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2824GO:0005554NDFunctionmolecular function unknown
2824GO:0007399NASProcessnervous system development
2824GO:0016020IEAComponentmembrane
2824GO:0016021NASComponentintegral to membrane
2824GO:0030154IEAProcesscell differentiation
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2824IPR001614Myelin_PLPMyelin proteolipid protein PLP
2824GPM6B_HUMANQ13491IPR001614Myelin_PLPMyelin proteolipid protein PLP

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