Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:286
Official Symbol:ANK1
Other Aliases:ANK|SPH1|SPH2
See related:HGNC:492|MIM:182900|HPRD:01693
Chromosome:8
Location:8p11.1
Gene Description:ankyrin 1, erythrocytic
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0343
ORGANISM:human
Entrez Gene ID:286
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:11733
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11733CBCerebellum79.4638271331787100.0
11733CTXCerebral cortex68.110269546508860.8219013214111
11733HIPHippocampal region38.677862167358452.8698673248291
11733HPFHippocampal formation48.354278564453156.1192455291748
11733HYHypothalamus50.928251266479546.0973014831543
11733LSXLateral septal complex35.798051834106426.6391935348511
11733MBMidbrain75.585742950439583.9796371459961
11733MYMedulla85.1275100708008100.0
11733OLFOlfactory bulb71.843872070312567.3731861114502
11733PPons76.605270385742299.9106483459473
11733PALPallidum61.581861495971766.0589752197266
11733RHPRetrohippocampal region63.318761825561560.3888874053955
11733sAMYStriatum-like amygdalar nuclei47.259359359741238.5697937011719
11733STRStriatum40.146983146667531.7088732719421
11733STRdStriatum dorsal region36.325989246368428.698712348938
11733STRvStriatum ventral region49.96238422393837.9827032089233
11733THThalamus86.736976623535286.5943946838379
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
286GO:0003824IEAFunctioncatalytic activity
286GO:0005198NASFunctionstructural molecule activity
286GO:0005200ISSFunctionstructural constituent of cytoskeleton
286GO:0005200TASFunctionstructural constituent of cytoskeleton
286GO:0005515IEAFunctionprotein binding
286GO:0005856IEAComponentcytoskeleton
286GO:0005886NASComponentplasma membrane
286GO:0007010NASProcesscytoskeleton organization and biogenesis
286GO:0007165IEAProcesssignal transduction
286GO:0008093ISSFunctioncytoskeletal adaptor activity
286GO:0008093TASFunctioncytoskeletal adaptor activity
286GO:0015629NRComponentactin cytoskeleton
286GO:0016323ISSComponentbasolateral plasma membrane
286GO:0016323NASComponentbasolateral plasma membrane
286GO:0019899ISSFunctionenzyme binding
286GO:0019899TASFunctionenzyme binding
286GO:0030507ISSFunctionspectrin binding
286GO:0030507NASFunctionspectrin binding
286GO:0045199ISSProcessmaintenance of epithelial cell polarity
286GO:0045199TASProcessmaintenance of epithelial cell polarity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6005NP_000315.1Rhesus blood group-associated glycoproteinHPRD01582
-6709NP_003118.1spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)HPRD01684
-7074NP_003244.1T-cell lymphoma invasion and metastasis 1HPRD02820
-7273NP_003310.2titin isoform N2-BHPRD01787
-84224NP_115640.1hypothetical protein LOC84224HPRD10633
NP_065209.1--AE2HPRD01693
NP_065209.1--NeurofascinHPRD01693
NP_065209.1--obscurinHPRD01693
NP_065209.16709-SpectrinHPRD01693
NP_065209.16709-Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)HPRD01693
NP_065209.184224-Hypothetical protein AE2HPRD01693
NP_065209.17074-T cell lymphoma invasion and metastasis 1HPRD01693
NP_065209.17273-TitinHPRD01693
NP_065209.16005-Rhesus blood group associated glycoproteinHPRD01693
NP_065209.16521NP_000333.1solute carrier family 4, anion exchanger, member 1HPRD01693
NP_065209.16521NP_000333.1solute carrier family 4, anion exchanger, member 1HPRD00175
NP_065209.13897NP_000416.1L1 cell adhesion molecule isoform 1 precursorHPRD01693
NP_065209.13897NP_000416.1L1 cell adhesion molecule isoform 1 precursorHPRD02394
NP_065209.16508NP_005061.1solute carrier family 4, anion exchanger, member 3 isoform 1HPRD00109
NP_065209.16508NP_005061.1solute carrier family 4, anion exchanger, member 3 isoform 1HPRD01693
NP_065209.184033NP_443075.1obscurin, cytoskeletal calmodulin and titin-interacting RhoGEFHPRD10551
NP_065209.184033NP_443075.1obscurin, cytoskeletal calmodulin and titin-interacting RhoGEFHPRD01693
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
286
286IPR002110ANKAnkyrin
286IPR000488DeathDeath
286IPR013555TRP_2Transient receptor ion channel II
286IPR000906ZU5ZU5
286ANK1_HUMANP16157IPR002110ANKAnkyrin
286ANK1_HUMANP16157IPR000488DeathDeath
286ANK1_HUMANP16157IPR013555TRP_2Transient receptor ion channel II
286ANK1_HUMANP16157IPR000906ZU5ZU5

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