Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2861
Official Symbol:GPR37
Other Aliases:EDNRBL|PAELR|hET(B)R-LP
See related:HGNC:4494|MIM:602583|HPRD:03992
Chromosome:7
Location:7q31
Gene Description:G protein-coupled receptor 37 (endothelin receptor type B-like)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0847
ORGANISM:human
Entrez Gene ID:2861
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-2.5 :: -2.1 :: -1.7 :: -1.8
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14763CBCerebellum57.974086761474642.0948333740234
14763CTXCerebral cortex52.240538597106934.4909071922302
14763HIPHippocampal region66.982831954956147.9797382354736
14763HPFHippocampal formation62.869113922119147.9119815826416
14763HYHypothalamus64.401709556579650.0031499862671
14763LSXLateral septal complex63.404400825500546.3534364700317
14763MBMidbrain62.707979202270550.6508498191833
14763MYMedulla75.919147491455164.8806018829346
14763OLFOlfactory bulb61.298305511474640.3768715858459
14763PPons71.304267883300862.1356544494629
14763PALPallidum68.692506790161150.9322490692139
14763RHPRetrohippocampal region57.13040113449148.90149974823
14763sAMYStriatum-like amygdalar nuclei52.191593647003230.7957770824432
14763STRStriatum52.845727920532232.5599565505981
14763STRdStriatum dorsal region50.373528480529831.9342770576477
14763STRvStriatum ventral region56.387915611267131.328106880188
14763THThalamus59.460993766784735.8977184295654
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2861GO:0001584IEAFunctionrhodopsin-like receptor activity
2861GO:0004872IEAFunctionreceptor activity
2861GO:0005887TASComponentintegral to plasma membrane
2861GO:0007165IEAProcesssignal transduction
2861GO:0007186TASProcessG-protein coupled receptor protein signaling pathway
2861GO:0016020IEAComponentmembrane
2861GO:0016526IEAFunctionG-protein coupled receptor activity, unknown ligand
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-10273NP_005852.1STIP1 homology and U-Box containing protein 1HPRD06232
NP_005293.15071-ParkinHPRD03992
NP_005293.15071NP_004553.1parkin isoform 1HPRD03967
NP_005293.110273NP_005852.1STIP1 homology and U-Box containing protein 1HPRD03992
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2861GPR37_HUMANO15354IPR001556Bombsn_rcptBombesin receptor
2861GPR37_HUMANO15354IPR002185DopaD4_rcptDopamine D4 receptor
2861GPR37_HUMANO15354IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
2861GPR37_HUMANO15354IPR003909GPR37_rcptGPR37 orphan receptor

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