Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:286887
Official Symbol:KRT6E
Other Aliases:MGC102925
See related:HGNC:20406|HPRD:17247
Chromosome:12
Location:12q13.13
Gene Description:keratin 6E
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0840
ORGANISM:human
Entrez Gene ID:286887
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.6 :: -2.8 :: -2.6
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
16687CBCerebellum3.293239593505864.98254108428955
16687CTXCerebral cortex0.7777683138847351.28089761734009
16687HIPHippocampal region0.3753088414669040.506213426589966
16687HPFHippocampal formation0.3206343948841090.509519398212433
16687HYHypothalamus0.06126324459910390.113472051918507
16687LSXLateral septal complex0.06931345909833910.0909175425767899
16687MBMidbrain0.2426673918962480.366608023643494
16687MYMedulla0.6724541187286380.831706821918488
16687OLFOlfactory bulb1.440174937248232.56624555587769
16687PPons0.1635719835758210.310533463954926
16687PALPallidum0.08290287852287290.294238448143005
16687RHPRetrohippocampal region0.2502475380897520.511439204216003
16687sAMYStriatum-like amygdalar nuclei0.139575168490410.179397374391556
16687STRStriatum0.1129732504487040.112483136355877
16687STRdStriatum dorsal region0.1244300082325940.10594429820776
16687STRvStriatum ventral region0.1063703969120980.144452229142189
16687THThalamus0.3291405141353610.462654531002045
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
286887GO:0005198NASFunctionstructural molecule activity
286887GO:0005882NASComponentintermediate filament
286887GO:0007010NASProcesscytoskeleton organization and biogenesis
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
286887K2C6D_HUMANP48667IPR002952EggshellEggshell protein
286887K2C6D_HUMANP48667IPR001664IFIntermediate filament protein
286887K2C6D_HUMANP48667IPR002957Keratin_IKeratin, type I
286887K2C6D_HUMANP48667IPR003054Keratin_IIType II keratin
286887K2C6D_HUMANP48667IPR000533TropomyosinTropomyosin
286887K2C6E_HUMANP48668IPR002952EggshellEggshell protein
286887K2C6E_HUMANP48668IPR001664IFIntermediate filament protein
286887K2C6E_HUMANP48668IPR002957Keratin_IKeratin, type I
286887K2C6E_HUMANP48668IPR003054Keratin_IIType II keratin
286887K2C6E_HUMANP48668IPR000533TropomyosinTropomyosin

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