Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2890
Official Symbol:GRIA1
Other Aliases:GLUH1|GLUR1|GLURA|HBGR1|MGC133252
See related:HGNC:4571|MIM:138248|HPRD:00695
Chromosome:5
Location:5q33|5q31.1
Gene Description:glutamate receptor, ionotropic, AMPA 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0850
ORGANISM:human
Entrez Gene ID:2890
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.4 :: 1.6 :: 2.2
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14799CBCerebellum8.319603919982919.07151126861572
14799CTXCerebral cortex13.15063667297368.01881217956543
14799HIPHippocampal region81.7666015625100.0
14799HPFHippocampal formation64.128646850585974.4560470581055
14799HYHypothalamus4.046470642089842.50784063339233
14799LSXLateral septal complex44.285118103027331.2416801452637
14799MBMidbrain3.272326469421392.09728407859802
14799MYMedulla0.6707080006599430.635520100593567
14799OLFOlfactory bulb26.880611419677715.8740510940552
14799PPons3.02190876007081.57444751262665
14799PALPallidum6.653995037078864.20824193954468
14799RHPRetrohippocampal region40.260162353515630.5869483947754
14799sAMYStriatum-like amygdalar nuclei16.51537513732918.71599674224854
14799STRStriatum18.883531570434610.2685232162476
14799STRdStriatum dorsal region12.79009532928476.8972110748291
14799STRvStriatum ventral region32.742565155029314.9347467422485
14799THThalamus4.318500041961672.4107460975647
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2890GO:0004872IEAFunctionreceptor activity
2890GO:0004971NRFunctionalpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
2890GO:0005215IEAFunctiontransporter activity
2890GO:0005216IEAFunctionion channel activity
2890GO:0005234IEAFunctionglutamate-gated ion channel activity
2890GO:0005267IEAFunctionpotassium channel activity
2890GO:0005886TASComponentplasma membrane
2890GO:0006811IEAProcession transport
2890GO:0006813IEAProcesspotassium ion transport
2890GO:0007165TASProcesssignal transduction
2890GO:0007268TASProcesssynaptic transmission
2890GO:0015277TASFunctionkainate selective glutamate receptor activity
2890GO:0016021IEAComponentintegral to membrane
2890GO:0045211IEAComponentpostsynaptic membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-2893NP_000820.1glutamate receptor, ionotrophicHPRD00694
-9456NP_004263.1homer 1HPRD09211
-3309NP_005338.1heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)HPRD00682
-6386NP_005616.1syndecan binding protein (syntenin)HPRD03741
-10369NP_006069.1voltage-dependent calcium channel gamma-2 subunitHPRD04220
-9463NP_036539.1protein interacting with C kinase 1HPRD16176
-2898NP_068775.1glutamate receptor 6 isoform 1 precursorHPRD00692
NP_000818.1--PICK1HPRD00695
NP_000818.19456-Homer 1HPRD00695
NP_000818.12893-Glutamate receptor, ionotropic AMPA 4HPRD00695
NP_000818.12898-Glutamate receptor, ionotropic kainate 2HPRD00695
NP_000818.13309-Heat shock 70kD protein 5HPRD00695
NP_000818.110369-Calcium channel, voltage dependent, gamma subunit 2HPRD00695
NP_000818.16386-SynteninHPRD00695
NP_000818.12895NP_001501.1glutamate receptor, ionotropic, delta 2BIND54860
NP_000818.17220NP_003295.1transient receptor potential cation channel, subfamily C, member 1HPRD11894
NP_000818.185461NP_203752.1TPR domain, ankyrin-repeat and coiled-coil-containingHPRD18146
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2890GRIA1_HUMANP42261IPR001828ANF_lig_bd_rcptExtracellular ligand-binding receptor
2890GRIA1_HUMANP42261IPR001311glu_rcpt_sol_bdSolute-binding protein/glutamate receptor
2890GRIA1_HUMANP42261IPR001320Iontro_glu_rcptIonotropic glutamate receptor
2890GRIA1_HUMANP42261IPR001622K+channel_poreK+ channel, pore region
2890GRIA1_HUMANP42261IPR001508NMDA_rcptNMDA receptor
2890GRIA1_HUMANP42261IPR002088PPTAProtein prenyltransferase, alpha subunit

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