Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2891
Official Symbol:GRIA2
Other Aliases:GLUR2|GLURB|HBGR2
See related:HGNC:4572|MIM:138247|HPRD:04726
Chromosome:4
Location:4q32-q33
Gene Description:glutamate receptor, ionotropic, AMPA 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0191
ORGANISM:human
Entrez Gene ID:2891
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:14800
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0380
ORGANISM:human
Entrez Gene ID:2891
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:29627
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:EVIM1136
ORGANISM:human
Entrez Gene ID:2891
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12716423
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Ventral Tegmental Area
Drug Effects:Upregulated
Fold Change:-
KARG Evidence 4
KARG ID:EVIM1144
ORGANISM:human
Entrez Gene ID:2891
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12716423
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Ventral Tegmental Area
Drug Effects:Upregulated
Fold Change:-
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14800CBCerebellum100.0100.0
14800CTXCerebral cortex100.0100.0
14800HIPHippocampal region100.0100.0
14800HPFHippocampal formation100.0100.0
14800HYHypothalamus100.0100.0
14800LSXLateral septal complex100.0100.0
14800MBMidbrain100.0100.0
14800MYMedulla100.0100.0
14800OLFOlfactory bulb100.0100.0
14800PPons100.0100.0
14800PALPallidum100.0100.0
14800RHPRetrohippocampal region100.0100.0
14800sAMYStriatum-like amygdalar nuclei100.0100.0
14800STRStriatum100.0100.0
14800STRdStriatum dorsal region100.0100.0
14800STRvStriatum ventral region100.0100.0
14800THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2891GO:0004872IEAFunctionreceptor activity
2891GO:0004970IEAFunctionionotropic glutamate receptor activity
2891GO:0004971TASFunctionalpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
2891GO:0005215IEAFunctiontransporter activity
2891GO:0005216IEAFunctionion channel activity
2891GO:0005234IEAFunctionglutamate-gated ion channel activity
2891GO:0005267IEAFunctionpotassium channel activity
2891GO:0005886TASComponentplasma membrane
2891GO:0006811IEAProcession transport
2891GO:0006813IEAProcesspotassium ion transport
2891GO:0007165TASProcesssignal transduction
2891GO:0007268TASProcesssynaptic transmission
2891GO:0015277TASFunctionkainate selective glutamate receptor activity
2891GO:0016020IEAComponentmembrane
2891GO:0016021IEAComponentintegral to membrane
2891GO:0045211IEAComponentpostsynaptic membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2891IPR001828ANF_lig_bd_rcptExtracellular ligand-binding receptor
2891IPR001311glu_rcpt_sol_bdSolute-binding protein/glutamate receptor
2891IPR001320Iontro_glu_rcptIonotropic glutamate receptor
2891IPR001622K+channel_poreK+ channel, pore region
2891IPR001508NMDA_rcptNMDA receptor

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