Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2897
Official Symbol:GRIK1
Other Aliases:EAA3|EEA3|GLR5|GLUR5
See related:HGNC:4579|MIM:138245|HPRD:00693
Chromosome:21
Location:21q22.11
Gene Description:glutamate receptor, ionotropic, kainate 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM1137
ORGANISM:human
Entrez Gene ID:2897
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12716423
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Ventral Tegmental Area
Drug Effects:Upregulated
Fold Change:-
KARG Evidence 2
KARG ID:EVIM1145
ORGANISM:human
Entrez Gene ID:2897
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12716423
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Ventral Tegmental Area
Drug Effects:Upregulated
Fold Change:-
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14805CBCerebellum22.94048182169667.5487022399902
14805CTXCerebral cortex42.399007797241232.5701338450114
14805HIPHippocampal region24.590654373168930.288454691569
14805HPFHippocampal formation40.236176172892343.7515347798665
14805HYHypothalamus66.887105305989655.4024276733398
14805LSXLateral septal complex56.099140167236341.9329058329264
14805MBMidbrain41.917467117309634.5602741241455
14805MYMedulla35.826269149780338.5079752604167
14805OLFOlfactory bulb81.987832387288471.7531242370605
14805PPons41.668764114379942.3091977437337
14805PALPallidum53.955081939697355.3506647745768
14805RHPRetrohippocampal region61.962294260660858.5424029032389
14805sAMYStriatum-like amygdalar nuclei69.693201700846465.3524894714355
14805STRStriatum17.065243721008314.5978492101034
14805STRdStriatum dorsal region4.127357482910163.76610358556112
14805STRvStriatum ventral region19.585420608520514.8819138209025
14805THThalamus60.981343587239650.022886912028
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2897GO:0004872IEAFunctionreceptor activity
2897GO:0005215IEAFunctiontransporter activity
2897GO:0005216IEAFunctionion channel activity
2897GO:0005234IEAFunctionglutamate-gated ion channel activity
2897GO:0005267IEAFunctionpotassium channel activity
2897GO:0005887TASComponentintegral to plasma membrane
2897GO:0006811IEAProcession transport
2897GO:0006813IEAProcesspotassium ion transport
2897GO:0007215TASProcessglutamate signaling pathway
2897GO:0007268TASProcesssynaptic transmission
2897GO:0007417TASProcesscentral nervous system development
2897GO:0015277TASFunctionkainate selective glutamate receptor activity
2897GO:0045211IEAComponentpostsynaptic membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-9456NP_004263.1homer 1HPRD09211
-6386NP_005616.1syndecan binding protein (syntenin)HPRD03741
-9463NP_036539.1protein interacting with C kinase 1HPRD16176
-9463NP_036539.1protein interacting with C kinase 1HPRD16176
NP_000821.1--PICK1HPRD00693
NP_000821.1--PICK1HPRD00693
NP_000821.19456-Homer 1HPRD00693
NP_000821.16386-SynteninHPRD00693
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2897IPR001828ANF_lig_bd_rcptExtracellular ligand-binding receptor
2897IPR001311glu_rcpt_sol_bdSolute-binding protein/glutamate receptor
2897IPR001320Iontro_glu_rcptIonotropic glutamate receptor
2897IPR001622K+channel_poreK+ channel, pore region
2897IPR001508NMDA_rcptNMDA receptor
2897GRIK1_HUMANP39086IPR001828ANF_lig_bd_rcptExtracellular ligand-binding receptor
2897GRIK1_HUMANP39086IPR001311glu_rcpt_sol_bdSolute-binding protein/glutamate receptor
2897GRIK1_HUMANP39086IPR001320Iontro_glu_rcptIonotropic glutamate receptor
2897GRIK1_HUMANP39086IPR001622K+channel_poreK+ channel, pore region
2897GRIK1_HUMANP39086IPR001508NMDA_rcptNMDA receptor

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