Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2901
Official Symbol:GRIK5
Other Aliases:EAA2|GRIK2|KA2
See related:HGNC:4583|MIM:600283|HPRD:02614
Chromosome:19
Location:19q13.2
Gene Description:glutamate receptor, ionotropic, kainate 5
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0334
ORGANISM:human
Entrez Gene ID:2901
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:14809
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM1138
ORGANISM:human
Entrez Gene ID:2901
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12716423
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Ventral Tegmental Area
Drug Effects:Upregulated
Fold Change:-
KARG Evidence 3
KARG ID:EVIM1146
ORGANISM:human
Entrez Gene ID:2901
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12716423
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Ventral Tegmental Area
Drug Effects:Upregulated
Fold Change:-
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14809CBCerebellum71.530456542968873.3869743347168
14809CTXCerebral cortex100.0100.0
14809HIPHippocampal region100.0100.0
14809HPFHippocampal formation100.0100.0
14809HYHypothalamus100.0100.0
14809LSXLateral septal complex100.0100.0
14809MBMidbrain100.099.893138885498
14809MYMedulla90.466590881347782.1086959838867
14809OLFOlfactory bulb100.0100.0
14809PPons90.1210937578.0090675354004
14809PALPallidum100.0100.0
14809RHPRetrohippocampal region100.0100.0
14809sAMYStriatum-like amygdalar nuclei100.0100.0
14809STRStriatum100.0100.0
14809STRdStriatum dorsal region100.0100.0
14809STRvStriatum ventral region100.0100.0
14809THThalamus100.093.3979644775391
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2901GO:0004872IEAFunctionreceptor activity
2901GO:0004970IEAFunctionionotropic glutamate receptor activity
2901GO:0005215IEAFunctiontransporter activity
2901GO:0005216IEAFunctionion channel activity
2901GO:0005234IEAFunctionglutamate-gated ion channel activity
2901GO:0005267IEAFunctionpotassium channel activity
2901GO:0006811IEAProcession transport
2901GO:0006813IEAProcesspotassium ion transport
2901GO:0007268NASProcesssynaptic transmission
2901GO:0015277IDAFunctionkainate selective glutamate receptor activity
2901GO:0016020IEAComponentmembrane
2901GO:0016021NASComponentintegral to membrane
2901GO:0045211IEAComponentpostsynaptic membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2901GRIK5_HUMANQ16478IPR001828ANF_lig_bd_rcptExtracellular ligand-binding receptor
2901GRIK5_HUMANQ16478IPR001311glu_rcpt_sol_bdSolute-binding protein/glutamate receptor
2901GRIK5_HUMANQ16478IPR001320Iontro_glu_rcptIonotropic glutamate receptor
2901GRIK5_HUMANQ16478IPR001622K+channel_poreK+ channel, pore region
2901GRIK5_HUMANQ16478IPR001508NMDA_rcptNMDA receptor

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