Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2902
Official Symbol:GRIN1
Other Aliases:NMDA1|NMDAR1|NR1
See related:HGNC:4584|MIM:138249|HPRD:15926
Chromosome:9
Location:9q34.3
Gene Description:glutamate receptor, ionotropic, N-methyl D-aspartate 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0134
ORGANISM:human
Entrez Gene ID:2902
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:14810
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM1135
ORGANISM:human
Entrez Gene ID:2902
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12716423
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Ventral Tegmental Area
Drug Effects:Upregulated
Fold Change:-
KARG Evidence 3
KARG ID:EVIM1143
ORGANISM:human
Entrez Gene ID:2902
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12716423
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Ventral Tegmental Area
Drug Effects:Upregulated
Fold Change:-
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14810CBCerebellum99.666210174560594.1236457824707
14810CTXCerebral cortex100.0100.0
14810HIPHippocampal region100.0100.0
14810HPFHippocampal formation100.0100.0
14810HYHypothalamus100.098.0347480773926
14810LSXLateral septal complex100.0100.0
14810MBMidbrain100.0100.0
14810MYMedulla100.0100.0
14810OLFOlfactory bulb100.0100.0
14810PPons96.5527114868164100.0
14810PALPallidum100.0100.0
14810RHPRetrohippocampal region100.0100.0
14810sAMYStriatum-like amygdalar nuclei100.0100.0
14810STRStriatum100.0100.0
14810STRdStriatum dorsal region100.0100.0
14810STRvStriatum ventral region100.0100.0
14810THThalamus98.2843437194824100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2902GO:0000287IEAFunctionmagnesium ion binding
2902GO:0003774ISSFunctionmotor activity
2902GO:0003774TASFunctionmotor activity
2902GO:0004872IEAFunctionreceptor activity
2902GO:0004970IEAFunctionionotropic glutamate receptor activity
2902GO:0004972ISSFunctionN-methyl-D-aspartate selective glutamate receptor activity
2902GO:0004972NASFunctionN-methyl-D-aspartate selective glutamate receptor activity
2902GO:0005215IEAFunctiontransporter activity
2902GO:0005216IEAFunctionion channel activity
2902GO:0005234IEAFunctionglutamate-gated ion channel activity
2902GO:0005267IEAFunctionpotassium channel activity
2902GO:0005509IEAFunctioncalcium ion binding
2902GO:0006811IEAProcession transport
2902GO:0006812ISSProcesscation transport
2902GO:0006812NASProcesscation transport
2902GO:0006813IEAProcesspotassium ion transport
2902GO:0006874ISSProcesscalcium ion homeostasis
2902GO:0006874NASProcesscalcium ion homeostasis
2902GO:0007215ISSProcessglutamate signaling pathway
2902GO:0007215NASProcessglutamate signaling pathway
2902GO:0007268ISSProcesssynaptic transmission
2902GO:0007268NASProcesssynaptic transmission
2902GO:0007611ISSProcesslearning and/or memory
2902GO:0007611NASProcesslearning and/or memory
2902GO:0016020IEAComponentmembrane
2902GO:0016021IEAComponentintegral to membrane
2902GO:0016594ISSFunctionglycine binding
2902GO:0016594NASFunctionglycine binding
2902GO:0016595ISSFunctionglutamate binding
2902GO:0016595NASFunctionglutamate binding
2902GO:0016933ISSFunctionglycine-gated ion channel activity
2902GO:0016933NASFunctionglycine-gated ion channel activity
2902GO:0017146IDAComponentN-methyl-D-aspartate selective glutamate receptor complex
2902GO:0017146ISSComponentN-methyl-D-aspartate selective glutamate receptor complex
2902GO:0030425IDAComponentdendrite
2902GO:0030425ISSComponentdendrite
2902GO:0030426ISSComponentgrowth cone
2902GO:0045211IEAComponentpostsynaptic membrane
2902GO:0045471ISSProcessresponse to ethanol
2902GO:0048167ISSProcessregulation of synaptic plasticity
2902GO:0048167NASProcessregulation of synaptic plasticity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7074NP_003244.1T-cell lymphoma invasion and metastasis 1BIND215402
-7082NP_003248.2tight junction protein 1 isoform aHPRD03002
-8831NP_006763.1synaptic Ras GTPase activating protein 1HPRD16018
-5518NP_055040.2alpha isoform of regulatory subunit A, protein phosphatase 2HPRD16184
-22839NP_055717.2disks large-associated protein 4 isoform aHPRD16826
-80086NP_079295.1tubulin, alpha 4HPRD18242
-4133NP_114034.1microtubule-associated protein 2 isoform 3HPRD01140
-10142NP_671700.1A-kinase anchor protein 9 isoform 1HPRD04921
-340719NP_955631.1nanos homolog 1 isoform 1HPRD16302
NP_000823.4155871NP_057853.1Tat--
NP_000823.4155871NP_057853.1Tat--
NP_015566.1--CalmodulinHPRD15926
NP_015566.12903-N-methyl D-aspartate receptor subunit 2AHPRD15926
NP_015566.14747-Neurofilament light polypeptideHPRD15926
NP_015566.16709-Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)HPRD15926
NP_015566.110524-HIV 1 Tat interacting proteinHPRD15926
NP_015566.111113-CitronHPRD15926
NP_015566.122839-Discs large associated protein 4HPRD15926
NP_015566.13192-Heterogeneous nuclear ribonucleoprotein UHPRD15926
NP_015566.13265-H-RasHPRD15926
NP_015566.13303-Heat shock 70 KD protein 1AHPRD15926
NP_015566.1340719-Nanos homolog 1HPRD15926
NP_015566.14133-Microtubule associated protein 2HPRD15926
NP_015566.14627-Myosin heavy chain 9, nonmuscleHPRD15926
NP_015566.15518-Serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, alpha isoformHPRD15926
NP_015566.15520-Protein phosphatase 2 regulatory subunit B alphaHPRD15926
NP_015566.15579-Protein kinase C, beta 1HPRD15926
NP_015566.15581-Protein kinase C epsilonHPRD15926
NP_015566.15582-Protein kinase C, gammaHPRD15926
NP_015566.15605-MAP2K2HPRD15926
NP_015566.15911-Ras related protein 2AHPRD15926
NP_015566.16197-Ribosomal protein S6 kinase alpha 3HPRD15926
NP_015566.17082-Tight junction protein 1HPRD15926
NP_015566.17187-TRAF3HPRD15926
NP_015566.180086-Tubulin, alpha 4HPRD15926
NP_015566.18831-Synaptic Ras GTPase activating protein 1HPRD15926
NP_015566.19118-Internexin, alphaHPRD15926
NP_015566.16667-Transcription factor Sp1HPRD15926
NP_015566.16670-Transcription factor Sp3HPRD15926
NP_015566.14763AAA59925.1Human neurofibromin (NF1) gene, and translated productsHPRD15926
NP_015566.12903NP_000824.1N-methyl-D-aspartate receptor subunit 2A precursorBIND54895
NP_015566.12904NP_000825.1N-methyl-D-aspartate receptor subunit 2B precursorHPRD15926
NP_015566.12906NP_000827.1N-methyl-D-aspartate receptor subunit 2D precursorHPRD15926
NP_015566.15327NP_000921.1plasminogen activator, tissue type isoform 1 preproproteinHPRD01419
NP_015566.15327NP_000921.1plasminogen activator, tissue type isoform 1 preproproteinHPRD15926
NP_015566.1116443NP_597702.1glutamate receptor, ionotropic, N-methyl-D-aspartate 3AHPRD15926
NP_015566.110142NP_671700.1A-kinase anchor protein 9 isoform 1HPRD15926
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2902IPR001828ANF_lig_bd_rcptExtracellular ligand-binding receptor
2902IPR001311glu_rcpt_sol_bdSolute-binding protein/glutamate receptor
2902IPR000337GPCR_MgrGPCR, family 3, metabotropic glutamate receptor-like
2902IPR001320Iontro_glu_rcptIonotropic glutamate receptor
2902IPR001622K+channel_poreK+ channel, pore region
2902IPR001508NMDA_rcptNMDA receptor
2902NMDZ1_HUMANQ05586IPR001828ANF_lig_bd_rcptExtracellular ligand-binding receptor
2902NMDZ1_HUMANQ05586IPR001311glu_rcpt_sol_bdSolute-binding protein/glutamate receptor
2902NMDZ1_HUMANQ05586IPR000337GPCR_MgrGPCR, family 3, metabotropic glutamate receptor-like
2902NMDZ1_HUMANQ05586IPR001320Iontro_glu_rcptIonotropic glutamate receptor
2902NMDZ1_HUMANQ05586IPR001622K+channel_poreK+ channel, pore region
2902NMDZ1_HUMANQ05586IPR001508NMDA_rcptNMDA receptor

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