Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2903
Official Symbol:GRIN2A
Other Aliases:NMDAR2A|NR2A
See related:HGNC:4585|MIM:138253|HPRD:00698
Chromosome:16
Location:16p13.2
Gene Description:glutamate receptor, ionotropic, N-methyl D-aspartate 2A
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0327
ORGANISM:human
Entrez Gene ID:2903
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:14811
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14811CBCerebellum5.175327539443977.23155629634857
14811CTXCerebral cortex45.531541824340826.7865777015686
14811HIPHippocampal region71.390462875366286.8704032897949
14811HPFHippocampal formation58.882045745849669.6965198516846
14811HYHypothalamus1.510804146528241.88412472605705
14811LSXLateral septal complex2.427387088537221.30377802252769
14811MBMidbrain3.775496244430543.94933885335922
14811MYMedulla1.994738817214971.68703231215477
14811OLFOlfactory bulb26.626812934875514.6122150421143
14811PPons1.336880862712861.40224868059158
14811PALPallidum0.954312875866890.782855860888958
14811RHPRetrohippocampal region40.964410781860426.2164549827576
14811sAMYStriatum-like amygdalar nuclei3.331991836428642.23852530121803
14811STRStriatum5.211098194122313.41975921392441
14811STRdStriatum dorsal region5.462053924798973.66804619133472
14811STRvStriatum ventral region6.314406156539923.8558424115181
14811THThalamus8.297750473022467.71253836154938
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2903GO:0000287IEAFunctionmagnesium ion binding
2903GO:0004872IEAFunctionreceptor activity
2903GO:0004972TASFunctionN-methyl-D-aspartate selective glutamate receptor activity
2903GO:0005215IEAFunctiontransporter activity
2903GO:0005216IEAFunctionion channel activity
2903GO:0005234IEAFunctionglutamate-gated ion channel activity
2903GO:0005509IEAFunctioncalcium ion binding
2903GO:0005887TASComponentintegral to plasma membrane
2903GO:0006811IEAProcession transport
2903GO:0007215TASProcessglutamate signaling pathway
2903GO:0007268TASProcesssynaptic transmission
2903GO:0007611TASProcesslearning and/or memory
2903GO:0045211IEAComponentpostsynaptic membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3603AAQ86961.1Homo sapiens neural interleukin 16 precursor protein mRNA, complete cds.HPRD04329
-6714NP_005408.1proto-oncogene tyrosine-protein kinase SRCHPRD01819
-9743NP_055530.2Rho GTPase-activating proteinHPRD12257
-10207NP_733750.2InaD-like protein isoform 1HPRD04434
NP_000824.1--PLC gammaHPRD00698
NP_000824.1--CIPPHPRD00698
NP_000824.1--NR3BHPRD00698
NP_000824.1--NR1HPRD00698
NP_000824.1--NR3AHPRD00698
NP_000824.16714-c-SrcHPRD00698
NP_000824.13603-Interleukin 16HPRD00698
NP_000824.13603AAQ86961.1Homo sapiens neural interleukin 16 precursor protein mRNA, complete cds.BIND180363
NP_000824.15775NP_002821.1protein tyrosine phosphatase, non-receptor type 4HPRD00698
NP_000824.19229NP_004737.2discs large homolog-associated protein 1 isoform alphaHPRD00698
NP_000824.1155871NP_057853.1Tat--
NT_010393.15---BIND185487
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2903NMDE1_HUMANQ12879IPR001311glu_rcpt_sol_bdSolute-binding protein/glutamate receptor
2903NMDE1_HUMANQ12879IPR001320Iontro_glu_rcptIonotropic glutamate receptor
2903NMDE1_HUMANQ12879IPR001508NMDA_rcptNMDA receptor

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