Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2906
Official Symbol:GRIN2D
Other Aliases:EB11|NMDAR2D
See related:HGNC:4588|MIM:602717|HPRD:04095
Chromosome:19
Location:19q13.1-qter
Gene Description:glutamate receptor, ionotropic, N-methyl D-aspartate 2D
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0434
ORGANISM:human
Entrez Gene ID:2906
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:24412
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14814CBCerebellum3.258517801761634.08345031738281
14814CTXCerebral cortex2.220345854759222.2902969121933
14814HIPHippocampal region0.6771917194128040.812574401497841
14814HPFHippocampal formation0.711068436503410.727284178137779
14814HYHypothalamus0.4925051331520080.435356542468071
14814LSXLateral septal complex0.5451968312263490.470504611730576
14814MBMidbrain2.644935369491582.81962615251541
14814MYMedulla1.334881439805031.39861717820168
14814OLFOlfactory bulb5.96893543004996.31907260417938
14814PPons0.7901578247547150.893745213747025
14814PALPallidum0.7539976239204410.618913605809212
14814RHPRetrohippocampal region0.7153133153915410.564888820052147
14814sAMYStriatum-like amygdalar nuclei0.3657109737396240.497027903795242
14814STRStriatum0.9031417965888980.866141811013222
14814STRdStriatum dorsal region0.6548389419913290.814120344817638
14814STRvStriatum ventral region1.812709331512451.17804922163486
14814THThalamus0.9924544990062711.04064407944679
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2906GO:0000287IEAFunctionmagnesium ion binding
2906GO:0004872IEAFunctionreceptor activity
2906GO:0004972NRFunctionN-methyl-D-aspartate selective glutamate receptor activity
2906GO:0005215IEAFunctiontransporter activity
2906GO:0005216IEAFunctionion channel activity
2906GO:0005234IEAFunctionglutamate-gated ion channel activity
2906GO:0005509IEAFunctioncalcium ion binding
2906GO:0005887NRComponentintegral to plasma membrane
2906GO:0006811IEAProcession transport
2906GO:0007165NASProcesssignal transduction
2906GO:0045211IEAComponentpostsynaptic membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3603AAQ86961.1Homo sapiens neural interleukin 16 precursor protein mRNA, complete cds.HPRD04329
-7082NP_003248.2tight junction protein 1 isoform aHPRD03002
-8831NP_006763.1synaptic Ras GTPase activating protein 1HPRD16018
-5518NP_055040.2alpha isoform of regulatory subunit A, protein phosphatase 2HPRD16184
-22839NP_055717.2disks large-associated protein 4 isoform aHPRD16826
-4133NP_114034.1microtubule-associated protein 2 isoform 3HPRD01140
-10207NP_733750.2InaD-like protein isoform 1HPRD04434
-340719NP_955631.1nanos homolog 1 isoform 1HPRD16302
NP_000827.13603-Interleukin 16HPRD04095
NP_000827.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2906NMDE4_HUMANO15399IPR001828ANF_lig_bd_rcptExtracellular ligand-binding receptor
2906NMDE4_HUMANO15399IPR001311glu_rcpt_sol_bdSolute-binding protein/glutamate receptor
2906NMDE4_HUMANO15399IPR001320Iontro_glu_rcptIonotropic glutamate receptor
2906NMDE4_HUMANO15399IPR001508NMDA_rcptNMDA receptor
2906NMDE4_HUMANO15399IPR000694PRO_richProline-rich region

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