Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2908
Official Symbol:NR3C1
Other Aliases:GCCR|GCR|GR|GRL
See related:HGNC:7978|MIM:138040|HPRD:00679
Chromosome:5
Location:5q31.3
Gene Description:nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0091
ORGANISM:human
Entrez Gene ID:2908
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:14815
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14815CBCerebellum16.396796703338612.9593855142593
14815CTXCerebral cortex26.1129691600816.315660238266
14815HIPHippocampal region20.491898775100714.3078474998474
14815HPFHippocampal formation20.373184442520113.8979948759079
14815HYHypothalamus6.738267183303834.19709926843643
14815LSXLateral septal complex4.937581062316892.79960227012634
14815MBMidbrain4.228557527065283.42448854446411
14815MYMedulla3.191782653331762.68157753348351
14815OLFOlfactory bulb8.784459710121155.40234026312828
14815PPons3.131664574146272.96861985325813
14815PALPallidum5.346617698669433.25009727478027
14815RHPRetrohippocampal region20.493401348590913.682958483696
14815sAMYStriatum-like amygdalar nuclei8.467950105667115.52474272251129
14815STRStriatum6.192834854125983.58524072170258
14815STRdStriatum dorsal region6.629029273986823.89198052883148
14815STRvStriatum ventral region4.553834080696112.16542541980743
14815THThalamus25.99443912506119.5744876861572
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2908GO:0003700TASFunctiontranscription factor activity
2908GO:0004883TASFunctionglucocorticoid receptor activity
2908GO:0005496IEAFunctionsteroid binding
2908GO:0005515IPIFunctionprotein binding
2908GO:0005634TASComponentnucleus
2908GO:0005737TASComponentcytoplasm
2908GO:0005759TASComponentmitochondrial matrix
2908GO:0006355IEAProcessregulation of transcription, DNA-dependent
2908GO:0006366TASProcesstranscription from RNA polymerase II promoter
2908GO:0006954NRProcessinflammatory response
2908GO:0007165TASProcesssignal transduction
2908GO:0007530IEAProcesssex determination
2908GO:0008270IEAFunctionzinc ion binding
2908GO:0008289IEAFunctionlipid binding
2908GO:0043565IEAFunctionsequence-specific DNA binding
2908GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-4306NP_000892.1nuclear receptor subfamily 3, group C, member 2HPRD02991
-3211NP_002135.1homeo box B1HPRD00855
-3725NP_002219.1v-jun avian sarcoma virus 17 oncogene homologHPRD01302
-5451NP_002688.1POU domain, class 2, transcription factor 1HPRD01250
-5452NP_002689.1POU domain, class 2, transcription factor 2HPRD01251
-5894NP_002871.1v-raf-1 murine leukemia viral oncogene homolog 1HPRD01265
-6595NP_003061.2SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2 isoform aHPRD02483
-6595NP_003061.3SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2 isoform aHPRD02483
-6598NP_003064.2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 isoform aHPRD03364
-6602NP_003067.2SWI/SNF-related matrix-associated actin-dependent regulator of chromatin d1 isoform aHPRD03438
-6605NP_003070.3SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e1HPRD04382
-6776NP_003143.2signal transducer and activator of transcription 5AHPRD03301
-7329NP_003336.1ubiquitin-conjugating enzyme E2IHPRD09045
-8204NP_003480.1receptor interacting protein 140HPRD03927
-8648NP_003734.3nuclear receptor coactivator 1 isoform 1HPRD04070
-8991NP_003935.2selenium binding protein 1HPRD05007
-9282NP_004220.2cofactor required for Sp1 transcriptional activation, subunit 2, 150kDaHPRD02172
-3175NP_004489.1one cut domain, family member 1HPRD05002
-3416NP_004960.1insulysinHPRD00894
-7704NP_005997.2promyelocytic leukemia zinc finger proteinHPRD11762
-9611NP_006302.2nuclear receptor co-repressor 1HPRD02911
-9612NP_006303.1nuclear receptor co-repressor 2HPRD02910
-10499NP_006531.1nuclear receptor coactivator 2HPRD09066
-10728NP_006592.2unactive progesterone receptor, 23 kDHPRD06138
-11319NP_009196.1suppressor of S. cerevisiae gcr2HPRD11032
-6777NP_036580.2signal transducer and activator of transcription 5BHPRD05037
-24148NP_036601.2PRP6 pre-mRNA processing factor 6 homologHPRD10729
-10891NP_037393.1peroxisome proliferative activated receptor gamma coactivator 1HPRD05155
-23054NP_054790.1nuclear receptor coactivator 6HPRD05599
-27043NP_055204.1proline-, glutamic acid-, leucine-rich protein 1HPRD10144
-7041NP_057011.2androgen receptor coactivator ARA55HPRD03831
-5970NP_068810.1v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65HPRD01241
-6774NP_644805.1signal transducer and activator of transcription 3 isoform 1HPRD00026
NP_000167.1--TubulinHPRD00679
NP_000167.1--CalmodulinHPRD00679
NP_000167.1--FKBP52HPRD00679
NP_000167.1--Receptor accessory factorHPRD00679
NP_000167.1--RAP46HPRD00679
NP_000167.1--Protein kinase AHPRD00679
NP_000167.1--GT198HPRD00679
NP_000167.1--Pbx1HPRD00679
NP_000167.1--Importin alphaHPRD00679
NP_000167.15970-NFKB3HPRD00679
NP_000167.13725-c JunHPRD00679
NP_000167.13416-Insulin degrading enzymeHPRD00679
NP_000167.18991-Selenium binding protein 1HPRD00679
NP_000167.16595-SMARCA2HPRD00679
NP_000167.16777-STAT5BHPRD00679
NP_000167.16774-STAT3HPRD00679
NP_000167.16776-STAT5AHPRD00679
NP_000167.15451-Octamer binding transcription factor 1HPRD00679
NP_000167.15452-Octamer binding transcription factor 2HPRD00679
NP_000167.18204-Nuclear receptor interacting protein 1HPRD00679
NP_000167.13175-Hepatocyte nuclear factor 6HPRD00679
NP_000167.19282-CRSP2HPRD00679
NP_000167.123054-Nuclear receptor coactivator 6HPRD00679
NP_000167.15763-ParathymosinHPRD00679
NP_000167.16598-SMARCB1HPRD00679
NP_000167.110728-Unactive progesterone receptor 23KDHPRD00679
NP_000167.110891-PPAR gamma coactivator 1HPRD00679
NP_000167.17041-HIC5HPRD00679
NP_000167.15894-RAF1HPRD00679
NP_000167.14306-Mineralocorticoid receptorHPRD00679
NP_000167.19611-Nuclear receptor corepressor 1HPRD00679
NP_000167.19612-Nuclear receptor corepressor 2HPRD00679
NP_000167.13303-Heat shock 70 KD protein 1AHPRD00679
NP_000167.18648-SRC1HPRD00679
NP_000167.127043-Proline glutamic acid leucine-rich protein 1HPRD00679
NP_000167.13211-HOX B1HPRD00679
NP_000167.16602-SMARCD1HPRD00679
NP_000167.16605-SMARCE1HPRD00679
NP_000167.15449NP_000297.1POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1)HPRD00679
NP_000167.17157NP_000537.2tumor protein p53BIND57648
NP_000167.17157NP_000537.2tumor protein p53HPRD00679
NP_000167.17157NP_000537.2tumor protein p53HPRD01859
NP_000167.13557NP_000568.1interleukin 1 receptor antagonist isoform 3HPRD00978
NP_000167.14791NP_002493.2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)HPRD00679
NP_000167.14791NP_002493.2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)HPRD01239
NP_000167.16908NP_003185.1TATA box binding proteinHPRD00679
NP_000167.16908NP_003185.1TATA box binding proteinHPRD02511
NP_000167.17295NP_003320.1thioredoxinHPRD01761
NP_000167.17295NP_003320.1thioredoxinHPRD00679
NP_000167.17341NP_003343.1SMT3 suppressor of mif two 3 homolog 1 isoform a precursorHPRD00679
NP_000167.17341NP_003343.1SMT3 suppressor of mif two 3 homolog 1 isoform a precursorHPRD03554
NP_000167.17533NP_003396.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, eta polypeptideHPRD00679
NP_000167.17533NP_003396.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, eta polypeptideHPRD00215
NP_000167.14790NP_003989.1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)HPRD00679
NP_000167.14790NP_003989.1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)HPRD01238
NP_000167.17818NP_004623.1death-associated protein 3HPRD00679
NP_000167.17818NP_004623.1death-associated protein 3HPRD03646
NP_000167.15927NP_005047.1retinoblastoma binding protein 2BIND133402
NP_000167.13303NP_005336.2heat shock 70kDa protein 1AHPRD00774
NP_000167.13320NP_005339.1heat shock 90kDa protein 1, alphaHPRD00777
NP_000167.13320NP_005339.1heat shock 90kDa protein 1, alphaHPRD00679
NP_000167.14691NP_005372.1nucleolinHPRD00679
NP_000167.14691NP_005372.1nucleolinHPRD01245
NP_000167.110155NP_005753.1tripartite motif-containing 28 proteinHPRD00679
NP_000167.110155NP_005753.1tripartite motif-containing 28 proteinHPRD03445
NP_000167.14088NP_005893.1MAD, mothers against decapentaplegic homolog 3HPRD00679
NP_000167.14088NP_005893.1MAD, mothers against decapentaplegic homolog 3HPRD04380
NP_000167.17251NP_006283.1tumor susceptibility gene 101HPRD00679
NP_000167.17251NP_006283.1tumor susceptibility gene 101HPRD03229
NP_000167.110499NP_006531.1nuclear receptor coactivator 2BIND209401
NP_000167.110980NP_006824.2COP9 signalosome subunit 6HPRD16735
NP_000167.18805NP_056989.2transcriptional intermediary factor 1 alpha isoform aHPRD00679
NP_000167.18805NP_056989.2transcriptional intermediary factor 1 alpha isoform aHPRD04556
NP_000167.129893NP_057640.1TBP-1 interacting protein isoform 2HPRD16362
NP_000167.179039NP_076977.3DEAD (Asp-Glu-Ala-Asp) box polypeptide 54HPRD13129
NP_000167.13192NP_114032.1heterogeneous nuclear ribonucleoprotein U isoform aHPRD04185
NP_000167.13192NP_114032.1heterogeneous nuclear ribonucleoprotein U isoform aHPRD00679
NP_000167.1155807NP_057852.2Vpr--
NP_000167.1155807NP_057852.2Vpr--
NP_000167.1155807NP_057852.2Vpr--
NP_000167.1155807NP_057852.2Vpr--
NP_000167.1155807NP_057852.2Vpr--
NP_000167.1155807NP_057852.2Vpr--
NP_000167.1155807NP_057852.2Vpr--
NP_000167.1155807NP_057852.2Vpr--
NP_000167.1155807NP_057852.2Vpr--
NP_000167.1155807NP_057852.2Vpr--
NP_000167.1155807NP_057852.2Vpr--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2908IPR001409Glcrtcd_rcptGlucocorticoid receptor
2908IPR000536Hrmn_rcpt_lig_bdNuclear hormone receptor, ligand-binding
2908IPR001628Hrmn_rcpt_DNA_bdNuclear hormone receptor, DNA-binding
2908IPR001723Str_hrmn_rcptSteroid hormone receptor
2908IPR000324VitD_rcptVitamin D receptor
2908IPR013629Znf-C4_CZinc finger, C4-type, C-terminal
2908GCR_HUMANP04150IPR001409Glcrtcd_rcptGlucocorticoid receptor
2908GCR_HUMANP04150IPR000536Hrmn_rcpt_lig_bdNuclear hormone receptor, ligand-binding
2908GCR_HUMANP04150IPR001628Hrmn_rcpt_DNA_bdNuclear hormone receptor, DNA-binding
2908GCR_HUMANP04150IPR001723Str_hrmn_rcptSteroid hormone receptor
2908GCR_HUMANP04150IPR000324VitD_rcptVitamin D receptor
2908GCR_HUMANP04150IPR013629Znf-C4_CZinc finger, C4-type, C-terminal

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