Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2912
Official Symbol:GRM2
Other Aliases:GLUR2|GPRC1B|MGLUR2|mGlu2
See related:HGNC:4594|MIM:604099|HPRD:04977
Chromosome:3
Location:3p21.1
Gene Description:glutamate receptor, metabotropic 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVID0023
ORGANISM:human
Entrez Gene ID:2912
Evidence Type:Database Annotations
Evidence ID Type:OMIM
Evidence ID:MIM:604099
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
108068CBCerebellum15.533733367919923.0803565979004
108068CTXCerebral cortex8.632002830505377.0594162940979
108068HIPHippocampal region8.5396585464477516.3528652191162
108068HPFHippocampal formation10.209410667419413.9432153701782
108068HYHypothalamus3.436493396759033.12522172927856
108068LSXLateral septal complex1.552175521850591.81629431247711
108068MBMidbrain1.779002189636232.1392936706543
108068MYMedulla2.564440250396732.58758783340454
108068OLFOlfactory bulb17.034484863281216.2608528137207
108068PPons2.630105018615722.60606813430786
108068PALPallidum0.6214451789855960.575149536132812
108068RHPRetrohippocampal region13.361779212951711.4814338684082
108068sAMYStriatum-like amygdalar nuclei0.6440060138702390.597023844718933
108068STRStriatum0.7205295562744140.781276702880859
108068STRdStriatum dorsal region0.476280540227890.509603381156921
108068STRvStriatum ventral region0.9591680765151981.05642199516296
108068THThalamus3.561592817306523.52459955215454
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2912GO:0004872IEAFunctionreceptor activity
2912GO:0005887TASComponentintegral to plasma membrane
2912GO:0007165IEAProcesssignal transduction
2912GO:0007186IEAProcessG-protein coupled receptor protein signaling pathway
2912GO:0007194TASProcessnegative regulation of adenylate cyclase activity
2912GO:0007268TASProcesssynaptic transmission
2912GO:0008067IEAFunctionmetabotropic glutamate, GABA-B-like receptor activity
2912GO:0008067TASFunctionmetabotropic glutamate, GABA-B-like receptor activity
2912GO:0016020IEAComponentmembrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6002NP_937872.1regulator of G-protein signalling 12 isoform 1HPRD03943
NC_000003.96597NP_003063.2SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4BIND128106
NC_000003.95978NP_005603.2RE1-silencing transcription factorBIND128074
NC_000003.96601NP_620706.1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin c2 isoform bBIND128108
NP_000830.1--G alpha 15HPRD04977
NP_000830.1--G alpha qlHPRD04977
NP_000830.16002-Regulator of G protein signaling 12HPRD04977
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2912MGR2_HUMANQ14416IPR001828ANF_lig_bd_rcptExtracellular ligand-binding receptor
2912MGR2_HUMANQ14416IPR002455GABAB_rcptMetabotropic gamma-aminobutyric acid receptor, type B
2912MGR2_HUMANQ14416IPR000337GPCR_MgrGPCR, family 3, metabotropic glutamate receptor-like
2912MGR2_HUMANQ14416IPR000162Mtglu_rcptMetabotropic glutamate receptor
2912MGR2_HUMANQ14416IPR001234Mtglu_rcpt_3Metabotropic glutamate receptor 3
2912MGR2_HUMANQ14416IPR001458Mtglu_rcpt_2Metabotropic glutamate receptor 2
2912MGR2_HUMANQ14416IPR011500NCD3G_GPCRNine cysteines of 3 GPCR

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