Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2915
Official Symbol:GRM5
Other Aliases:GPRC1E|MGLUR5|MGLUR5A|MGLUR5B|mGlu5
See related:HGNC:4597|MIM:604102
Chromosome:11
Location:11q14.2-q14.3
Gene Description:glutamate receptor, metabotropic 5
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0246
ORGANISM:human
Entrez Gene ID:2915
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:108071
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0463
ORGANISM:human
Entrez Gene ID:2915
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:24418
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
108071CBCerebellum19.046756744384825.2474765777588
108071CTXCerebral cortex100.0100.0
108071HIPHippocampal region100.0100.0
108071HPFHippocampal formation100.0100.0
108071HYHypothalamus84.083744049072384.7455444335938
108071LSXLateral septal complex100.0100.0
108071MBMidbrain76.76128768920982.0467414855957
108071MYMedulla52.970925331115759.0721569061279
108071OLFOlfactory bulb100.0100.0
108071PPons50.279949188232454.0748920440674
108071PALPallidum94.3050003051758100.0
108071RHPRetrohippocampal region100.0100.0
108071sAMYStriatum-like amygdalar nuclei100.0100.0
108071STRStriatum100.0100.0
108071STRdStriatum dorsal region100.0100.0
108071STRvStriatum ventral region100.0100.0
108071THThalamus75.300771713256875.4130554199219
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2915GO:0004872IEAFunctionreceptor activity
2915GO:0005887TASComponentintegral to plasma membrane
2915GO:0007165IEAProcesssignal transduction
2915GO:0007186IEAProcessG-protein coupled receptor protein signaling pathway
2915GO:0007206TASProcessmetabotropic glutamate receptor, phospholipase C activating pathway
2915GO:0007268TASProcesssynaptic transmission
2915GO:0008067TASFunctionmetabotropic glutamate, GABA-B-like receptor activity
2915GO:0016020IEAComponentmembrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6002NP_937872.1regulator of G-protein signalling 12 isoform 1HPRD03943
BAA05892.1--Homer/Vesl proteinsHPRD04980
BAA05892.1--Vesl-1S/HomerHPRD04980
BAA05892.16002-Regulator of G protein signaling 12HPRD04980
NP_000833.19454NP_004829.2Homer, neuronal immediate early gene, 3BIND225222
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2915IPR001828ANF_lig_bd_rcptExtracellular ligand-binding receptor
2915IPR000337GPCR_MgrGPCR, family 3, metabotropic glutamate receptor-like
2915IPR001256Metaglu_rcpt_1Metabotropic glutamate receptor 1
2915IPR000162Mtglu_rcptMetabotropic glutamate receptor
2915IPR000202Mtglu_rcpt_5Metabotropic glutamate receptor 5
2915IPR011500NCD3G_GPCRNine cysteines of 3 GPCR

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