Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2923
Official Symbol:PDIA3
Other Aliases:ERp57|ERp60|ERp61|GRP57|GRP58|HsT17083|P58|PI-PLC
See related:HGNC:4606|MIM:602046|HPRD:03625
Chromosome:15
Location:15q15
Gene Description:protein disulfide isomerase family A, member 3
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0054
ORGANISM:human
Entrez Gene ID:2923
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:14827
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:QTL0052
ORGANISM:human
Entrez Gene ID:2923
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14827CBCerebellum60.4046421051025100.0
14827CTXCerebral cortex100.0100.0
14827HIPHippocampal region100.0100.0
14827HPFHippocampal formation100.0100.0
14827HYHypothalamus97.3028411865234100.0
14827LSXLateral septal complex87.21648025512785.8995742797852
14827MBMidbrain88.092468261718896.0460243225098
14827MYMedulla88.6551818847656100.0
14827OLFOlfactory bulb100.0100.0
14827PPons84.648952484130999.9229469299316
14827PALPallidum88.73675918579199.2590255737305
14827RHPRetrohippocampal region100.0100.0
14827sAMYStriatum-like amygdalar nuclei100.0100.0
14827STRStriatum100.0100.0
14827STRdStriatum dorsal region100.097.6572189331055
14827STRvStriatum ventral region97.314243316650498.3461036682129
14827THThalamus88.21125411987395.1133155822754
KARG Evidence 3
KARG ID:QTL0052
Trait:cocaine related behavior
Peak:69
Peak Marker: D2Byu3
Parents:BXD/Ty (B = C57BL/6, D = DBA/2) recombinant inbred
Evidence ID:10591541
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2923GO:0003756TASFunctionprotein disulfide isomerase activity
2923GO:0004197TASFunctioncysteine-type endopeptidase activity
2923GO:0004629TASFunctionphospholipase C activity
2923GO:0005783TASComponentendoplasmic reticulum
2923GO:0006118IEAProcesselectron transport
2923GO:0006606TASProcessprotein import into nucleus
2923GO:0006621TASProcessprotein retention in ER
2923GO:0007165TASProcesssignal transduction
2923GO:0016853IEAFunctionisomerase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6559NP_000330.1solute carrier family 12 (sodium/chloride transporters), member 3HPRD02984
-3458NP_000610.1interferon, gammaHPRD00957
-2995NP_002092.1glycophorin C isoform 1HPRD00193
NP_005304.3--MHC class IHPRD03625
NP_005304.33458-Interferon, gammaHPRD03625
NP_005304.32995-Glycophorin CHPRD03625
NP_005304.36890-Transporter 1 ATP binding cassette, subfamily BHPRD03625
NP_005304.36559-Solute carrier family 12 (sodium/chloride transporter), member 3HPRD03625
NP_005304.36513NP_006507.1solute carrier family 2 (facilitated glucose transporter), member 1HPRD03625
NP_005304.36513NP_006507.1solute carrier family 2 (facilitated glucose transporter), member 1HPRD00683
NP_005304.323621NP_036236.1beta-site APP-cleaving enzyme 1 isoform A preproproteinBIND262676
NP_005304.36774NP_644805.1signal transducer and activator of transcription 3 isoform 1HPRD03625
NP_005304.36774NP_644805.1signal transducer and activator of transcription 3 isoform 1HPRD00026
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2923PDIA3_HUMANP30101IPR006662ThioredThioredoxin-related
2923PDIA3_HUMANP30101IPR013766Thioredoxin_domThioredoxin domain
2923PDIA3_HUMANP30101IPR006663Thioredox_dom2Thioredoxin domain 2

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