Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2934
Official Symbol:GSN
Other Aliases:DKFZp313L0718
See related:HGNC:4620|MIM:137350|HPRD:00674
Chromosome:9
Location:9q33
Gene Description:gelsolin (amyloidosis, Finnish type)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0129
ORGANISM:human
Entrez Gene ID:2934
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:0.96 :: 0.68 :: 1.59 :: 1.70 :: -1.64 :: -1.53 :: -2.07
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
227753CBCerebellum51.596394538879466.7151927947998
227753CTXCerebral cortex46.841541290283240.4559183120728
227753HIPHippocampal region37.004034042358443.5432634353638
227753HPFHippocampal formation41.641360282897943.2661828994751
227753HYHypothalamus55.664325714111348.5228548049927
227753LSXLateral septal complex57.243379592895555.5458402633667
227753MBMidbrain65.114112854003963.689248085022
227753MYMedulla78.852220535278376.3708972930908
227753OLFOlfactory bulb49.928555488586447.9567584991455
227753PPons74.929601669311572.7415790557861
227753PALPallidum65.968460083007861.4583177566528
227753RHPRetrohippocampal region46.757240295410240.4350986480713
227753sAMYStriatum-like amygdalar nuclei51.408460617065448.6866245269775
227753STRStriatum53.455657005310149.0704469680786
227753STRdStriatum dorsal region57.378229141235453.889931678772
227753STRvStriatum ventral region37.450079917907729.1459565162659
227753THThalamus71.242404937744166.9228839874268
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2934GO:0003779IEAFunctionactin binding
2934GO:0005509TASFunctioncalcium ion binding
2934GO:0005515IPIFunctionprotein binding
2934GO:0005576IDAComponentextracellular region
2934GO:0005576NASComponentextracellular region
2934GO:0005829IDAComponentcytosol
2934GO:0015629TASComponentactin cytoskeleton
2934GO:0030041IDAProcessactin filament polymerization
2934GO:0051014IDAProcessactin filament severing
2934GO:0051016TASProcessbarbed-end actin filament capping
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3985AAH13051.1LIM domain kinase 2, isoform 1HPRD03585
-5829BAA18998.1paxillin gammaHPRD03937
-7408NP_003361.1vasodilator-stimulated phosphoprotein isoform 1HPRD03415
-7414NP_054706.1vinculin isoform meta-VCLHPRD01900
-9564NP_055382.1breast cancer anti-estrogen resistance 1HPRD04248
-53405NP_058625.1chloride intracellular channel 5HPRD06292
NP_000168.1--G-actinHPRD00674
NP_000168.1--TropomyosinHPRD00674
NP_000168.1--PIK3HPRD00674
NP_000168.153405-Chloride intracellular channel 5HPRD00674
NP_000168.17408-Vasodilator stimulated phosphoproteinHPRD00674
NP_000168.13985-LIM domain kinase 2HPRD00674
NP_000168.15829-PaxillinHPRD00674
NP_000168.17414-VinculinHPRD00674
NP_000168.19564-CRK associated substrateHPRD00674
NP_000168.19564-p130CASHPRD00674
NP_000168.17416NP_003365.1voltage-dependent anion channel 1HPRD00674
NP_000168.17416NP_003365.1voltage-dependent anion channel 1HPRD05137
NP_000168.123043NP_055843.1TRAF2 and NCK interacting kinaseHPRD00674
NP_000168.123043NP_055843.1TRAF2 and NCK interacting kinaseHPRD18206
NP_000168.11491938NP_057864.1p40BIND300751
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2934IPR007122GelsolinGelsolin
2934IPR007123GelsolnGelsolin region
2934GELS_HUMANP06396IPR007122GelsolinGelsolin
2934GELS_HUMANP06396IPR007123GelsolnGelsolin region

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