Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:2950
Official Symbol:GSTP1
Other Aliases:DFN7|FAEES3|GST3|PI
See related:HGNC:4638|MIM:134660|HPRD:00614
Chromosome:11
Location:11q13
Gene Description:glutathione S-transferase pi
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVID0010
ORGANISM:human
Entrez Gene ID:2950
Evidence Type:Database Annotations
Evidence ID Type:OMIM
Evidence ID:MIM:134660
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:QTL0248
ORGANISM:human
Entrez Gene ID:2950
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
225884CBCerebellum2.400677561759953.21515941619873
14870CBCerebellum71.841270446777398.1850051879883
14870CTXCerebral cortex100.0100.0
225884CTXCerebral cortex5.739793539047245.09251737594604
14870HIPHippocampal region100.0100.0
225884HIPHippocampal region8.453908681869518.51419591903687
14870HPFHippocampal formation100.0100.0
225884HPFHippocampal formation7.876292705535897.27460503578186
225884HYHypothalamus1.613234668970111.56022661924362
14870HYHypothalamus100.0100.0
225884LSXLateral septal complex0.9722262918949130.834145739674568
14870LSXLateral septal complex100.0100.0
225884MBMidbrain1.397117644548421.92740958929062
14870MBMidbrain100.0100.0
225884MYMedulla2.372989535331733.17194199562073
14870MYMedulla97.7423477172852100.0
14870OLFOlfactory bulb100.0100.0
225884OLFOlfactory bulb6.171440064907076.25120830535889
225884PPons2.230124890804293.31614887714386
14870PPons99.2791748046875100.0
225884PALPallidum0.6235607564449310.610528737306595
14870PALPallidum100.0100.0
14870RHPRetrohippocampal region100.0100.0
225884RHPRetrohippocampal region8.588318705558786.77258080244064
225884sAMYStriatum-like amygdalar nuclei0.9867215752601621.22681215405464
14870sAMYStriatum-like amygdalar nuclei100.0100.0
225884STRStriatum1.874841153621671.90046638250351
14870STRStriatum100.0100.0
14870STRdStriatum dorsal region100.092.4164047241211
225884STRdStriatum dorsal region2.35905325412752.51515060663223
225884STRvStriatum ventral region1.198298335075380.858759984374046
14870STRvStriatum ventral region100.0100.0
225884THThalamus2.213790759444242.53711639344692
14870THThalamus82.189247131347778.269660949707
KARG Evidence 3
KARG ID:QTL0248
Trait:METH responses for body temperature
Peak:0
Peak Marker:Gnblps1
Parents:C57BL/6J x DBA/2J intercross
Evidence ID:8987796
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
2950GO:0004364IEAFunctionglutathione transferase activity
2950GO:0005737TASComponentcytoplasm
2950GO:0006916TASProcessanti-apoptosis
2950GO:0007417TASProcesscentral nervous system development
2950GO:0008152IEAProcessmetabolism
2950GO:0016740IEAFunctiontransferase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5599NP_620637.1mitogen-activated protein kinase 8 isoform 1HPRD03100
AY324387.1121504NP_778224.1histone H4BIND258524
NP_000843.15599-JNK1HPRD00614
NP_000843.12950NP_000843.1glutathione transferaseHPRD00614
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
2950GSTP1_HUMANP09211IPR003080GST_alphaGlutathione S-transferase, alpha class
2950GSTP1_HUMANP09211IPR004046GST_CGlutathione S-transferase, C-terminal
2950GSTP1_HUMANP09211IPR004045GST_NGlutathione S-transferase, N-terminal
2950GSTP1_HUMANP09211IPR003082GST_piGlutathione S-transferase, Pi class

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