Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3035
Official Symbol:HARS
Other Aliases:FLJ20491|HRS
See related:HGNC:4816|MIM:142810|HPRD:00827
Chromosome:5
Location:5q31.3
Gene Description:histidyl-tRNA synthetase
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0288
ORGANISM:human
Entrez Gene ID:3035
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:15115
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
15115CBCerebellum3.226817607879643.86188489198685
15115CTXCerebral cortex1.225963979959490.845817565917969
15115HIPHippocampal region9.24227309226995.47495746612549
15115HPFHippocampal formation6.136823773384093.56920003890991
15115HYHypothalamus0.6897487565875050.519585080444813
15115LSXLateral septal complex0.2541615143418310.25196024030447
15115MBMidbrain0.8473914265632630.855432763695717
15115MYMedulla5.735358476638796.38837730884552
15115OLFOlfactory bulb4.636950194835662.73818761110306
15115PPons5.149030625820165.37488281726837
15115PALPallidum1.740456640720371.41259455680847
15115RHPRetrohippocampal region1.675719931721691.27147860825062
15115sAMYStriatum-like amygdalar nuclei0.9035750776529310.57646544277668
15115STRStriatum0.5085706785321240.351472601294518
15115STRdStriatum dorsal region0.4237408488988880.299974344670773
15115STRvStriatum ventral region0.6300517022609710.408337719738483
15115THThalamus0.8066890947520730.556032367050648
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3035GO:0000166IEAFunctionnucleotide binding
3035GO:0004821NASFunctionhistidine-tRNA ligase activity
3035GO:0005524NASFunctionATP binding
3035GO:0005737NASComponentcytoplasm
3035GO:0006412NASProcessprotein biosynthesis
3035GO:0006427IEAProcesshistidyl-tRNA aminoacylation
3035GO:0016874IEAFunctionligase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6125NP_000960.2ribosomal protein L5HPRD04699
-6897NP_689508.3threonyl-tRNA synthetaseHPRD01762
NP_002100.2--Elongation factor betaHPRD00827
NP_002100.2--Elongation factor gammaHPRD00827
NP_002100.26125-Ribosomal protein L5HPRD00827
NP_002100.26897-Threonyl tRNA synthetaseHPRD00827
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3035SYH_HUMANP12081IPR004154Anticodon_bdAnticodon-binding
3035SYH_HUMANP12081IPR002314tRNA-synt_2btRNA synthetase, class II (G, H, P and S)
3035SYH_HUMANP12081IPR006195tRNA_ligase_IIAminoacyl-transfer RNA synthetase, class II
3035SYH_HUMANP12081IPR000738WHEP-TRSWHEP-TRS

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