Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3087
Official Symbol:HHEX
Other Aliases:HEX|HMPH|HOX11L-PEN|PRH|PRHX
See related:HGNC:4901|MIM:604420|HPRD:06829
Chromosome:10
Location:10q23.33
Gene Description:homeobox, hematopoietically expressed
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0226
ORGANISM:human
Entrez Gene ID:3087
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ADMINISTRATION
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Upregulated
Fold Change:At least 2-folds difference
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3087GO:0003700TASFunctiontranscription factor activity
3087GO:0005634IEAComponentnucleus
3087GO:0006355IEAProcessregulation of transcription, DNA-dependent
3087GO:0007275TASProcessdevelopment
3087GO:0019735TASProcessantimicrobial humoral response (sensu Vertebrata)
3087GO:0043565IEAFunctionsequence-specific DNA binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5371NP_150241.1promyelocytic leukemia protein isoform 1HPRD00023
NP_002720.15371-PMLHPRD06829
NP_002720.17088NP_005068.2transducin-like enhancer protein 1BIND209448
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3087HHEX_HUMANQ03014IPR001356HomeoboxHomeobox
3087HHEX_HUMANQ03014IPR000047HTH_lambrepressrHelix-turn-helix motif, lambda-like repressor
3087HHEX_HUMANQ03014IPR000694PRO_richProline-rich region

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