Knowledgebase for Addiction-Related Genes
Home | Score | Chromosome | Pathway | Advanced Search | BLAST Search | Downloads | Publications | FAQ & Help |   

KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3091
Official Symbol:HIF1A
Other Aliases:HIF-1alpha|HIF1-ALPHA|MOP1|PASD8
See related:HGNC:4910|MIM:603348|HPRD:04517
Chromosome:14
Location:14q21-q24
Gene Description:hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0455
ORGANISM:human
Entrez Gene ID:3091
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:29560
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0140
ORGANISM:human
Entrez Gene ID:3091
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:1.40 :: 0.88 :: 1.02 :: 0.76 :: -1.59 :: -2.08 :: 0.60
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
15251CBCerebellum36.20440292358433.7450942993164
15251CTXCerebral cortex42.199417114257816.8637523651123
15251HIPHippocampal region25.950769424438522.3991069793701
15251HPFHippocampal formation31.514011383056619.774600982666
15251HYHypothalamus17.10769844055186.35386753082275
15251LSXLateral septal complex2.194188117980960.845970213413239
15251MBMidbrain16.13305091857917.73866271972656
15251MYMedulla22.247993469238313.8770427703857
15251OLFOlfactory bulb39.419269561767616.9194316864014
15251PPons17.00843811035168.97578144073486
15251PALPallidum17.33338356018077.80615329742432
15251RHPRetrohippocampal region40.569168090820317.2417030334473
15251sAMYStriatum-like amygdalar nuclei23.19310760498058.84088611602783
15251STRStriatum17.23072433471685.84326839447021
15251STRdStriatum dorsal region14.19558811187744.68833446502686
15251STRvStriatum ventral region28.14018630981459.03246212005615
15251THThalamus15.32660198211678.18474960327148
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3091GO:0001666IDAProcessresponse to hypoxia
3091GO:0003700IEAFunctiontranscription factor activity
3091GO:0003705TASFunctionRNA polymerase II transcription factor activity, enhancer binding
3091GO:0004497IEAFunctionmonooxygenase activity
3091GO:0004871IEAFunctionsignal transducer activity
3091GO:0005506IEAFunctioniron ion binding
3091GO:0005515IPIFunctionprotein binding
3091GO:0005634IDAComponentnucleus
3091GO:0005634IEAComponentnucleus
3091GO:0006118IEAProcesselectron transport
3091GO:0006355IDAProcessregulation of transcription, DNA-dependent
3091GO:0006355IEAProcessregulation of transcription, DNA-dependent
3091GO:0007165IEAProcesssignal transduction
3091GO:0007165NASProcesssignal transduction
3091GO:0020037IEAFunctionheme binding
3091GO:0035035IPIFunctionhistone acetyltransferase binding
3091GO:0042592TASProcesshomeostasis
3091GO:0046982IPIFunctionprotein heterodimerization activity
3091GO:0046982TASFunctionprotein heterodimerization activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
--NC_000002.9Homo sapiens chromosome 2BIND257572
--NC_000002.9Homo sapiens chromosome 2BIND257569
-5230NP_000282.1phosphoglycerate kinase 1HPRD02412
-7157NP_000537.2tumor protein p53HPRD01859
-391104NP_001004319.1hypothetical protein LOC391104HPRD15648
-3725NP_002219.1v-jun avian sarcoma virus 17 oncogene homologHPRD01302
-4193NP_002383.1mouse double minute 2 homolog isoform MDM2HPRD01272
-5187NP_002607.1period 1HPRD03774
-5595NP_002737.1mitogen-activated protein kinase 3HPRD03479
-5702NP_002795.2proteasome 26S ATPase subunit 3HPRD01733
-8648NP_003734.3nuclear receptor coactivator 1 isoform 1HPRD04070
-7818NP_004623.1death-associated protein 3HPRD03646
-3320NP_005339.1heat shock 90kDa protein 1, alphaHPRD00777
-6667NP_612482.2Sp1 transcription factorBIND257575
-64344NP_690007.1hypoxia-inducible factor-3 alpha isoform aHPRD17104
NP_001521.1--Transcription intermediary factor 2HPRD04517
NP_001521.1---BIND13093
NP_001521.1---BIND196914
NP_001521.15230-Phosphoglycerate kinase 1HPRD04517
NP_001521.13320-HSP90AHPRD04517
NP_001521.17157-p53HPRD04517
NP_001521.15595-ERK1HPRD04517
NP_001521.14193-Oncoprotein Mdm2HPRD04517
NP_001521.17818-Death associated protein 3HPRD04517
NP_001521.17428-VHLHPRD04517
NP_001521.17428-VHLHPRD04517
NP_001521.15187-Period circadian protein 1HPRD04517
NP_001521.13725-c JunHPRD04517
NP_001521.15702-Proteasome 26S subunit, ATPase 3HPRD04517
NP_001521.17428--BIND215865
NP_001521.17422AF095785.1Homo sapiens vascular endothelial growth factor (VEGF) gene, promoter region and partial cdsBIND216590
NP_001521.15925NP_000312.1retinoblastoma 1BIND216588
NP_001521.17157NP_000537.2tumor protein p53BIND45557
NP_001521.17157NP_000537.2tumor protein p53BIND196927
NP_001521.17428NP_000542.1von Hippel-Lindau tumor suppressor isoform 1BIND13089
NP_001521.17428NP_000542.1von Hippel-Lindau tumor suppressor isoform 1BIND295821
NP_001521.15688NP_002783.1proteasome alpha 7 subunitHPRD05967
NP_001521.15688NP_002783.1proteasome alpha 7 subunitHPRD04517
NP_001521.18648NP_003734.3nuclear receptor coactivator 1 isoform 1HPRD04517
NP_001521.110956NP_006803.1amplified in osteosarcoma isoform 1 precursorBIND215862
NP_001521.110987NP_006828.1COP9 constitutive photomorphogenic homolog subunit 5BIND19165
NP_001521.155662NP_060372.1hypoxia-inducible factor 1, alpha subunit inhibitorHPRD09426
NP_001521.155662NP_060372.1hypoxia-inducible factor 1, alpha subunit inhibitorHPRD04517
NP_001521.154583NP_071334.1egl nine homolog 1BIND215861
NP_001521.1112399NP_071356.1egl nine homolog 3BIND215860
NP_851397.1---BIND197092
NP_851397.17157NP_000537.2tumor protein p53BIND197093
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3091IPR001092HLH_basicBasic helix-loop-helix dimerisation region bHLH
3091IPR001321HypoxindF1AHypoxia-inducible factor-1 alpha
3091IPR001067Nuc_translocatNuclear translocator
3091IPR000014PASPAS
3091IPR013655PAS_3PAS fold-3
3091HIF1A_HUMANQ16665IPR001092HLH_basicBasic helix-loop-helix dimerisation region bHLH
3091HIF1A_HUMANQ16665IPR001321HypoxindF1AHypoxia-inducible factor-1 alpha
3091HIF1A_HUMANQ16665IPR001067Nuc_translocatNuclear translocator
3091HIF1A_HUMANQ16665IPR000014PASPAS
3091HIF1A_HUMANQ16665IPR013655PAS_3PAS fold-3

© Center for Bioinformatics(CBI), Peking University
Any Comments and suggestions to : KARG GROUP.