Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3122
Official Symbol:HLA-DRA
Other Aliases:HLA-DRA1
See related:HGNC:4947|MIM:142860|HPRD:00833
Chromosome:6
Location:6p21.3
Gene Description:major histocompatibility complex, class II, DR alpha
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0308
ORGANISM:human
Entrez Gene ID:3122
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Downregulated
Fold Change:-0.74
KARG Evidence 2
KARG ID:EVIM0948
ORGANISM:human
Entrez Gene ID:3122
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.7 :: -1.6
KARG Evidence 3
KARG ID:HOT0058
ORGANISM:human
Entrez Gene ID:3122
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 4
KARG ID:HOT0023
ORGANISM:human
Entrez Gene ID:3122
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14968CBCerebellum2.457462310791023.1363627910614
14968CTXCerebral cortex0.7691371440887450.951159477233887
14968HIPHippocampal region0.6413976550102230.84451162815094
14968HPFHippocampal formation0.7458726167678830.93791925907135
14968HYHypothalamus0.5096838474273680.646399676799774
14968LSXLateral septal complex0.3926557004451750.375927031040192
14968MBMidbrain1.462274789810181.50922250747681
14968MYMedulla5.244410037994385.29525566101074
14968OLFOlfactory bulb1.688006639480591.36587107181549
14968PPons3.263488292694093.55091309547424
14968PALPallidum0.7526659369468690.998975813388824
14968RHPRetrohippocampal region0.8734084963798521.03215909004211
14968sAMYStriatum-like amygdalar nuclei0.6455436944961550.642002820968628
14968STRStriatum0.5366832017898560.778805077075958
14968STRdStriatum dorsal region0.5068830251693730.957651317119598
14968STRvStriatum ventral region0.6587847471237180.496821314096451
14968THThalamus1.128404617309571.16672265529633
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3122GO:0005764IDAComponentlysosome
3122GO:0005886IDAComponentplasma membrane
3122GO:0005887NASComponentintegral to plasma membrane
3122GO:0006955IEAProcessimmune response
3122GO:0006955NASProcessimmune response
3122GO:0016020IEAComponentmembrane
3122GO:0019884IEAProcessantigen presentation, exogenous antigen
3122GO:0019886IEAProcessantigen processing, exogenous antigen via MHC class II
3122GO:0045012IEAFunctionMHC class II receptor activity
3122GO:0045012NASFunctionMHC class II receptor activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_061984.1--CD82HPRD00833
NP_061984.125766AAH67364.1Huntingtin interacting protein C, isoform 1HPRD11044
NP_061984.13123NP_002115.1major histocompatibility complex, class II, DR beta 1 precursorHPRD00833
NP_061984.13123NP_002115.1major histocompatibility complex, class II, DR beta 1 precursorHPRD08349
NP_061984.13127NP_002116.2major histocompatibility complex, class II, DR beta 5 precursorHPRD09209
NP_061984.13127NP_002116.2major histocompatibility complex, class II, DR beta 5 precursorHPRD00833
NP_061984.13732NP_002222.1CD82 antigen isoform 1HPRD09004
NP_061984.13732NP_002222.1CD82 antigen isoform 1HPRD00833
NP_061984.14155NP_002376.1myelin basic protein isoform 2HPRD00833
NP_061984.14155NP_002376.1myelin basic protein isoform 2HPRD01158
NP_061984.1155030NP_057850.1Pr55(Gag)--
NP_061984.1155030NP_057850.1Pr55(Gag)--
NP_061984.1155871NP_057853.1Tat--
NP_061984.1155871NP_057853.1Tat--
NP_061984.1155030NP_579880.1capsid--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3122IPR007110Ig-likeImmunoglobulin-like
3122IPR003597Ig_c1Immunoglobulin C1 type
3122IPR003006Ig_MHCImmunoglobulin/major histocompatibility complex
3122IPR013151ImmunoglobulinImmunoglobulin
3122IPR001003MHC_II_alpha_NMHC class II, alpha chain, N-terminal

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