Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3125
Official Symbol:HLA-DRB3
Other Aliases:HLA-DR3B|MGC117330
See related:HGNC:4951|HPRD:09985
Chromosome:6
Location:6p21.3
Gene Description:major histocompatibility complex, class II, DR beta 3
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0857
ORGANISM:human
Entrez Gene ID:3125
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.4 :: -1.5
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3125GO:0005887NRComponentintegral to plasma membrane
3125GO:0006955IEAProcessimmune response
3125GO:0006955NASProcessimmune response
3125GO:0007165NASProcesssignal transduction
3125GO:0016020IEAComponentmembrane
3125GO:0016020NASComponentmembrane
3125GO:0016021IEAComponentintegral to membrane
3125GO:0019884IEAProcessantigen presentation, exogenous antigen
3125GO:0019886IEAProcessantigen processing, exogenous antigen via MHC class II
3125GO:0045012IEAFunctionMHC class II receptor activity
3125GO:0045012NASFunctionMHC class II receptor activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_072049.25443NP_000930.1proopiomelanocortin preproproteinHPRD09985
NP_072049.2155030NP_057850.1Pr55(Gag)--
NP_072049.2155030NP_057850.1Pr55(Gag)--
NP_072049.2155871NP_057853.1Tat--
NP_072049.2155871NP_057853.1Tat--
NP_072049.2155030NP_579880.1capsid--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
31252B31_HUMANP79483IPR007110Ig-likeImmunoglobulin-like
31252B31_HUMANP79483IPR003597Ig_c1Immunoglobulin C1 type
31252B31_HUMANP79483IPR003006Ig_MHCImmunoglobulin/major histocompatibility complex
31252B31_HUMANP79483IPR013151ImmunoglobulinImmunoglobulin
31252B31_HUMANP79483IPR000353MHC_II_beta_NMHC class II, beta chain, N-terminal

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