Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3127
Official Symbol:HLA-DRB5
Other Aliases:-
See related:HGNC:4953|MIM:604776|HPRD:09209
Chromosome:6
Location:6p21.3
Gene Description:major histocompatibility complex, class II, DR beta 5
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0400
ORGANISM:human
Entrez Gene ID:3127
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:294270
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:HOT0058
ORGANISM:human
Entrez Gene ID:3127
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:HOT0023
ORGANISM:human
Entrez Gene ID:3127
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14969CBCerebellum5.306688308715828.05296099185944
14969CTXCerebral cortex3.476144701242453.31091029942036
14969HIPHippocampal region2.113353922963142.07107439637184
14969HPFHippocampal formation3.130612261593342.82949276268482
14969HYHypothalamus0.7404729723930360.819301515817642
14969LSXLateral septal complex0.7109362334012991.27286100387573
14969MBMidbrain2.322504669427873.11798846721649
14969MYMedulla7.090815395116818.74191731214523
14969OLFOlfactory bulb3.016039714217192.77806650102139
14969PPons4.376853600144395.82368814945221
14969PALPallidum2.001783847808842.88323299586773
14969RHPRetrohippocampal region5.328193582594394.21021440625191
14969sAMYStriatum-like amygdalar nuclei0.9320677816867831.17570692300797
14969STRStriatum1.117355644702911.13892155885696
14969STRdStriatum dorsal region1.170370690524581.18445099890232
14969STRvStriatum ventral region1.086169183254240.826040685176849
14969THThalamus2.997249186038973.12437742948532
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3127GO:0005887TASComponentintegral to plasma membrane
3127GO:0006955IEAProcessimmune response
3127GO:0009596TASProcessdetection of pest, pathogen or parasite
3127GO:0016020IEAComponentmembrane
3127GO:0016021IEAComponentintegral to membrane
3127GO:0019884IEAProcessantigen presentation, exogenous antigen
3127GO:0019886IEAProcessantigen processing, exogenous antigen via MHC class II
3127GO:0045012IEAFunctionMHC class II receptor activity
3127GO:0045012TASFunctionMHC class II receptor activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_002116.2155030NP_057850.1Pr55(Gag)--
NP_002116.2155030NP_057850.1Pr55(Gag)--
NP_002116.2155871NP_057853.1Tat--
NP_002116.2155871NP_057853.1Tat--
NP_002116.2155030NP_579880.1capsid--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
31272B19_HUMANQ9TQE0IPR007110Ig-likeImmunoglobulin-like
31272B19_HUMANQ9TQE0IPR003597Ig_c1Immunoglobulin C1 type
31272B19_HUMANQ9TQE0IPR003006Ig_MHCImmunoglobulin/major histocompatibility complex
31272B19_HUMANQ9TQE0IPR013151ImmunoglobulinImmunoglobulin
31272B19_HUMANQ9TQE0IPR000353MHC_II_beta_NMHC class II, beta chain, N-terminal

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