Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3156
Official Symbol:HMGCR
Other Aliases:-
See related:HGNC:5006|MIM:142910|HPRD:00836
Chromosome:5
Location:5q13.3-q14
Gene Description:3-hydroxy-3-methylglutaryl-Coenzyme A reductase
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0431
ORGANISM:human
Entrez Gene ID:3156
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:25675
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0397
ORGANISM:human
Entrez Gene ID:3156
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.5 :: -1.1 :: 1.1 :: -1.4 :: -1
KARG Evidence 3
KARG ID:EVIM0465
ORGANISM:human
Entrez Gene ID:3156
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:1.4 :: 1.5 :: 1.1 :: -1.5 :: -1.2
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
15357CBCerebellum24.142901420593328.214243888855
15357CTXCerebral cortex94.405078887939570.1338424682617
15357HIPHippocampal region25.137965202331525.5765790939331
15357HPFHippocampal formation43.21944618225137.0235729217529
15357HYHypothalamus23.117529869079614.0106544494629
15357LSXLateral septal complex9.834547042846687.13498377799988
15357MBMidbrain19.211195945739715.4046235084534
15357MYMedulla38.474585533142132.7717237472534
15357OLFOlfactory bulb75.065153121948257.6677513122559
15357PPons25.562616348266620.4811344146729
15357PALPallidum23.161728858947818.2935886383057
15357RHPRetrohippocampal region70.403373718261752.1354904174805
15357sAMYStriatum-like amygdalar nuclei40.495574951171926.2691421508789
15357STRStriatum27.622442245483418.5405073165894
15357STRdStriatum dorsal region27.317003250122118.8050394058228
15357STRvStriatum ventral region28.019916534423817.4055328369141
15357THThalamus28.494913101196318.3868789672852
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3156GO:0004420IEAFunctionhydroxymethylglutaryl-CoA reductase (NADPH) activity
3156GO:0005624NRComponentmembrane fraction
3156GO:0005777IEAComponentperoxisome
3156GO:0005789TASComponentendoplasmic reticulum membrane
3156GO:0006629IEAProcesslipid metabolism
3156GO:0006695IEAProcesscholesterol biosynthesis
3156GO:0008354TASProcessgerm cell migration
3156GO:0008406TASProcessgonad development
3156GO:0016020IEAComponentmembrane
3156GO:0016021IEAComponentintegral to membrane
3156GO:0016491IEAFunctionoxidoreductase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3638NP_938150.1insulin induced gene 1 isoform 2HPRD03633
NP_000850.13638-INSIG1HPRD00836
NP_000850.190627NP_821074.1START domain containing 13 isoform alphaHPRD11607
NP_000850.190627NP_821074.1START domain containing 13 isoform alphaBIND218738
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3156HMDH_HUMANP04035IPR002202HMG-CoA_redHydroxymethylglutaryl-coenzyme A reductase
3156HMDH_HUMANP04035IPR000731SSD_5TMSterol-sensing 5TM box

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