Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3162
Official Symbol:HMOX1
Other Aliases:HO-1|bK286B10
See related:HGNC:5013|MIM:141250|HPRD:00782
Chromosome:22
Location:22q12|22q13.1
Gene Description:heme oxygenase (decycling) 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0427
ORGANISM:human
Entrez Gene ID:3162
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:1 :: -1.1 :: -1.6 :: -1.8 :: -1.4 :: -1.6
KARG Evidence 2
KARG ID:EVIM0495
ORGANISM:human
Entrez Gene ID:3162
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:1.1 :: 1.1 :: -1.2 :: -3.1 :: -1.4
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
15368CBCerebellum2.695665836334232.93727421760559
15368CTXCerebral cortex8.043157577514656.1329927444458
15368HIPHippocampal region5.858554840087895.62522077560425
15368HPFHippocampal formation6.201727867126465.13098287582397
15368HYHypothalamus10.65582370758067.92178440093994
15368LSXLateral septal complex2.530321836471562.23566269874573
15368MBMidbrain5.449533462524415.25827646255493
15368MYMedulla11.044536590576214.2315254211426
15368OLFOlfactory bulb14.910579681396512.089427947998
15368PPons10.479001998901411.5719766616821
15368PALPallidum6.59086704254156.32799816131592
15368RHPRetrohippocampal region6.743073463439944.41153812408447
15368sAMYStriatum-like amygdalar nuclei1.425583362579351.17007684707642
15368STRStriatum2.513237476348881.68103539943695
15368STRdStriatum dorsal region1.897531747817991.20684003829956
15368STRvStriatum ventral region5.173413753509523.2175624370575
15368THThalamus4.661201000213623.6924512386322
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3162GO:0004392TASFunctionheme oxygenase (decyclizing) activity
3162GO:0004871IMPFunctionsignal transducer activity
3162GO:0005506IEAFunctioniron ion binding
3162GO:0005624TASComponentmembrane fraction
3162GO:0005783TASComponentendoplasmic reticulum
3162GO:0005792IEAComponentmicrosome
3162GO:0006788IEAProcessheme oxidation
3162GO:0016491IEAFunctionoxidoreductase activity
3162GO:0043123IMPProcesspositive regulation of I-kappaB kinase/NF-kappaB cascade
3162GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-4842NP_000611.1nitric oxide synthase 1 (neuronal)HPRD01226
NP_002124.14842-Nitric oxide synthase 1HPRD00782
NP_002124.13162NP_002124.1heme oxygenase (decyclizing) 1HPRD00782
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3162HMOX1_HUMANP09601IPR002051Haem_OaseHaem oxygenase

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