Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3164
Official Symbol:NR4A1
Other Aliases:GFRP1|HMR|MGC9485|N10|NAK-1|NGFIB|NP10|NUR77|TR3
See related:HGNC:7980|MIM:139139|HPRD:00744
Chromosome:12
Location:12q13
Gene Description:nuclear receptor subfamily 4, group A, member 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0061
ORGANISM:human
Entrez Gene ID:3164
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:15370
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0470
ORGANISM:human
Entrez Gene ID:3164
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:79240
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
15370CBCerebellum59.41877365112341.8878612518311
15370CTXCerebral cortex100.098.089973449707
15370HIPHippocampal region53.201850891113358.3132438659668
15370HPFHippocampal formation71.42412948608473.6788730621338
15370HYHypothalamus24.282732009887715.7741379737854
15370LSXLateral septal complex34.265369415283225.4981174468994
15370MBMidbrain25.424198150634819.0712881088257
15370MYMedulla37.96854209899927.2495365142822
15370OLFOlfactory bulb100.097.9734916687012
15370PPons37.967826843261728.2462224960327
15370PALPallidum28.021736145019523.371787071228
15370RHPRetrohippocampal region93.881065368652386.021053314209
15370sAMYStriatum-like amygdalar nuclei46.831611633300841.2030506134033
15370STRStriatum76.571636199951273.5083770751953
15370STRdStriatum dorsal region85.427551269531280.5413990020752
15370STRvStriatum ventral region82.982002258300872.1948223114014
15370THThalamus28.155570983886718.6145873069763
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3164GO:0003700IEAFunctiontranscription factor activity
3164GO:0003707IEAFunctionsteroid hormone receptor activity
3164GO:0004879IEAFunctionligand-dependent nuclear receptor activity
3164GO:0005634IEAComponentnucleus
3164GO:0006350IEAProcesstranscription
3164GO:0006355IEAProcessregulation of transcription, DNA-dependent
3164GO:0007165TASProcesssignal transduction
3164GO:0008270IEAFunctionzinc ion binding
3164GO:0043565IEAFunctionsequence-specific DNA binding
3164GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-8850NP_003875.3p300/CBP-associated factorHPRD06780
-5469NP_004765.2peroxisome proliferator-activated receptor binding proteinHPRD05055
-9612NP_006303.1nuclear receptor co-repressor 2HPRD02910
-6258NP_008848.1retinoid X receptor, gamma isoform aHPRD01579
-5371NP_150241.1promyelocytic leukemia protein isoform 1HPRD00023
NP_002126.2--NR4A1HPRD00744
NP_002126.2--Steroid receptor coactivator 2HPRD00744
NP_002126.29612-Nuclear receptor corepressor 2HPRD00744
NP_002126.25371-PMLHPRD00744
NP_002126.25469-TRAP220HPRD00744
NP_002126.26258-Retinoid X receptor, gammaHPRD00744
NP_002126.28850-PCAFHPRD00744
NP_002126.28648NP_003734.3nuclear receptor coactivator 1 isoform 1HPRD04070
NP_002126.28648NP_003734.3nuclear receptor coactivator 1 isoform 1HPRD00744
NP_002126.28202NP_006525.1nuclear receptor coactivator 3HPRD03570
NP_002126.28202NP_006525.1nuclear receptor coactivator 3HPRD00744
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3164IPR001628Hrmn_rcpt_DNA_bdNuclear hormone receptor, DNA-binding
3164IPR003070Nuc_orph_rcptOrphan nuclear receptor
3164IPR003071Nuc_orp_HMR_rcptOrphan nuclear receptor, HMR type
3164IPR000324VitD_rcptVitamin D receptor
3164IPR013629Znf-C4_CZinc finger, C4-type, C-terminal
3164NR4A1_HUMANP22736IPR000536Hrmn_rcpt_lig_bdNuclear hormone receptor, ligand-binding
3164NR4A1_HUMANP22736IPR001628Hrmn_rcpt_DNA_bdNuclear hormone receptor, DNA-binding
3164NR4A1_HUMANP22736IPR003070Nuc_orph_rcptOrphan nuclear receptor
3164NR4A1_HUMANP22736IPR003071Nuc_orp_HMR_rcptOrphan nuclear receptor, HMR type
3164NR4A1_HUMANP22736IPR001723Str_hrmn_rcptSteroid hormone receptor
3164NR4A1_HUMANP22736IPR003993treacleTreacher Collins syndrome protein Treacle
3164NR4A1_HUMANP22736IPR000324VitD_rcptVitamin D receptor
3164NR4A1_HUMANP22736IPR013629Znf-C4_CZinc finger, C4-type, C-terminal

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