Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:322
Official Symbol:APBB1
Other Aliases:FE65|MGC:9072|RIR
See related:HGNC:581|MIM:602709|HPRD:04087
Chromosome:11
Location:11p15
Gene Description:amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0010
ORGANISM:human
Entrez Gene ID:322
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:11785
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11785CBCerebellum50.050.0
11785CTXCerebral cortex50.050.0
11785HIPHippocampal region50.050.0
11785HPFHippocampal formation50.050.0
11785HYHypothalamus50.050.0
11785LSXLateral septal complex50.050.0
11785MBMidbrain50.050.0
11785MYMedulla50.050.0
11785OLFOlfactory bulb50.050.0
11785PPons50.050.0
11785PALPallidum50.050.0
11785RHPRetrohippocampal region50.050.0
11785sAMYStriatum-like amygdalar nuclei50.050.0
11785STRStriatum50.050.0
11785STRdStriatum dorsal region50.050.0
11785STRvStriatum ventral region50.050.0
11785THThalamus50.050.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
322GO:0001540ISSFunctionbeta-amyloid binding
322GO:0001540NASFunctionbeta-amyloid binding
322GO:0005634ISSComponentnucleus
322GO:0007050ISSProcesscell cycle arrest
322GO:0007165ISSProcesssignal transduction
322GO:0007165NASProcesssignal transduction
322GO:0007409ISSProcessaxonogenesis
322GO:0007409NASProcessaxonogenesis
322GO:0008134ISSFunctiontranscription factor binding
322GO:0030027IDAComponentlamellipodium
322GO:0030027ISSComponentlamellipodium
322GO:0030048ISSProcessactin filament-based movement
322GO:0030308ISSProcessnegative regulation of cell growth
322GO:0030426IDAComponentgrowth cone
322GO:0030426ISSComponentgrowth cone
322GO:0035035ISSFunctionhistone acetyltransferase binding
322GO:0045202IDAComponentsynapse
322GO:0045202ISSComponentsynapse
322GO:0045449ISSProcessregulation of transcription
322GO:0045749ISSProcessnegative regulation of S phase of mitotic cell cycle
322GO:0050760ISSProcessnegative regulation of thymidylate synthase biosynthesis
322GO:0050821ISSProcessprotein stabilization
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-356NP_000630.1fas ligandHPRD00610
-51466NP_057421.1Enah/Vasp-likeHPRD10942
-10524NP_874369.1HIV-1 Tat interactive protein, 60kDa isoform 1HPRD03245
NP_001155.151466-Ena vasodilator stimulated phosphoprotein like proteinHPRD04087
NP_001155.1356-FAS ligandHPRD04087
NP_001155.110524-HIV 1 Tat interacting proteinHPRD04087
NP_001155.15621NP_000302.1prion protein preproproteinHPRD04087
NP_001155.1351NP_000475.1amyloid beta A4 protein precursor, isoform aHPRD00100
NP_001155.1351NP_000475.1amyloid beta A4 protein precursor, isoform aHPRD04087
NP_001155.1334NP_001633.1amyloid beta (A4) precursor-like protein 2HPRD04087
NP_001155.14035NP_002323.1low density lipoprotein-related protein 1HPRD04087
NP_001155.14035NP_002323.1low density lipoprotein-related protein 1HPRD00138
NP_001155.14036NP_004516.1low density lipoprotein-related protein 2HPRD04087
NP_001155.1333NP_005157.1amyloid precursor-like protein 1 isoform 2 precursorHPRD00102
NP_001155.1333NP_005157.1amyloid precursor-like protein 1 isoform 2 precursorHPRD04087
NP_001155.17024NP_005644.2transcription factor CP2HPRD04087
NP_001155.17024NP_005644.2transcription factor CP2HPRD01790
NP_001155.122883NP_055759.2calsyntenin 1HPRD04087
NP_001155.122883NP_055759.2calsyntenin 1HPRD10837
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
322IPR006020PTB_PIDPhosphotyrosine interaction region
322IPR002349WWWW
322IPR001202WW_Rsp5_WWPWW/Rsp5/WWP
322APBB1_HUMANO00213IPR006020PTB_PIDPhosphotyrosine interaction region
322APBB1_HUMANO00213IPR002349WWWW
322APBB1_HUMANO00213IPR001202WW_Rsp5_WWPWW/Rsp5/WWP

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