Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:326
Official Symbol:AIRE
Other Aliases:AIRE1|APECED|APS1|APSI|PGA1
See related:HGNC:360|MIM:607358|HPRD:06301
Chromosome:21
Location:21q22.3
Gene Description:autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0873
ORGANISM:human
Entrez Gene ID:326
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.5 :: -1.6
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11634CBCerebellum84.374332427978573.0999279022217
11634CTXCerebral cortex86.641162872314569.9707622528076
11634HIPHippocampal region79.159832000732467.9300651550293
11634HPFHippocampal formation87.309150695800874.5036563873291
11634HYHypothalamus70.168203353881854.5411643981934
11634LSXLateral septal complex55.114947795867936.9549419879913
11634MBMidbrain69.735870361328162.7016906738281
11634MYMedulla81.933998107910271.7678642272949
11634OLFOlfactory bulb100.082.3590660095215
11634PPons87.756687164306676.1275386810303
11634PALPallidum61.981274604797448.3876223564148
11634RHPRetrohippocampal region97.064262390136780.3957290649414
11634sAMYStriatum-like amygdalar nuclei66.045164108276459.5643825531006
11634STRStriatum62.030242919921953.3515057563782
11634STRdStriatum dorsal region59.088592529296953.1611456871033
11634STRvStriatum ventral region72.684295654296958.7740249633789
11634THThalamus67.654134750366259.829517364502
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
326GO:0003700TASFunctiontranscription factor activity
326GO:0005515IEAFunctionprotein binding
326GO:0005634NASComponentnucleus
326GO:0005737IEAComponentcytoplasm
326GO:0006350IEAProcesstranscription
326GO:0006355NASProcessregulation of transcription, DNA-dependent
326GO:0006959IEAProcesshumoral immune response
326GO:0008270IEAFunctionzinc ion binding
326GO:0045182IEAFunctiontranslation regulator activity
326GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-1387NP_004371.1CREB binding proteinHPRD02534
NP_000374.11387-CREBBPHPRD06301
NP_000374.1326NP_000374.1autoimmune regulator AIRE isoform 1HPRD06301
NP_000374.1326NP_000374.1autoimmune regulator AIRE isoform 1BIND13137
NP_000374.11387NP_004371.1CREB binding proteinBIND13138
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
326IPR001965Znf_PHDZinc finger, PHD-type
326AIRE_HUMANO43918IPR008087AIREAutoimmune regulator, AIRE
326AIRE_HUMANO43918IPR000770SANDSAND
326AIRE_HUMANO43918IPR004865Sp100Sp100
326AIRE_HUMANO43918IPR001965Znf_PHDZinc finger, PHD-type

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