Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3308
Official Symbol:HSPA4
Other Aliases:APG-2|HS24/P52|MGC131852|RY|hsp70|hsp70RY
See related:HGNC:5237|MIM:601113|HPRD:09025
Chromosome:5
Location:5q31.1-q31.2
Gene Description:heat shock 70kDa protein 4
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0546
ORGANISM:human
Entrez Gene ID:3308
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:266759
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
15525CBCerebellum28.42110633850188.7260665893555
15525CTXCerebral cortex100.0100.0
15525HIPHippocampal region100.0100.0
15525HPFHippocampal formation100.0100.0
15525HYHypothalamus100.0100.0
15525LSXLateral septal complex100.0100.0
15525MBMidbrain73.683235168457100.0
15525MYMedulla53.0840606689453100.0
15525OLFOlfactory bulb100.0100.0
15525PPons60.4949035644531100.0
15525PALPallidum100.0100.0
15525RHPRetrohippocampal region100.0100.0
15525sAMYStriatum-like amygdalar nuclei100.0100.0
15525STRStriatum100.0100.0
15525STRdStriatum dorsal region100.0100.0
15525STRvStriatum ventral region100.0100.0
15525THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3308GO:0000166IEAFunctionnucleotide binding
3308GO:0005524IEAFunctionATP binding
3308GO:0005524NASFunctionATP binding
3308GO:0005737NASComponentcytoplasm
3308GO:0006457IEAProcessprotein folding
3308GO:0006986IEAProcessresponse to unfolded protein
3308GO:0006986NASProcessresponse to unfolded protein
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-4306NP_000892.1nuclear receptor subfamily 3, group C, member 2HPRD02991
-9529NP_004864.1BCL2-associated athanogene 5 isoform bBIND195962
-134266NP_689620.2GrpE-like 2, mitochondrialHPRD17079
AAA02807.13838NP_002257.1karyopherin alpha 2BIND197134
NP_002145.34306-Mineralocorticoid receptorHPRD09025
NP_002145.3134266-GrpE like 2 mitochondrialHPRD09025
NP_002145.34215NP_002392.1MAP/ERK kinase kinase 3HPRD09025
NP_002145.38841NP_003874.2histone deacetylase 3HPRD09025
NP_002145.310454NP_006107.1mitogen-activated protein kinase kinase kinase 7 interacting protein 1 isoform alphaHPRD09025
NP_002145.37186NP_066961.2TNF receptor-associated factor 2HPRD09025
NP_002145.3155030NP_057850.1Pr55(Gag)--
NP_002145.3155030NP_057850.1Pr55(Gag)--
NP_002145.3155807NP_057852.2Vpr--
NP_002145.3155871NP_057853.1Tat--
NP_002145.3155030NP_579876.2matrix--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3308IPR001023Hsp70Heat shock protein Hsp70
3308IPR013126Hsp_70Heat shock protein 70
3308HSP74_HUMANP34932IPR001023Hsp70Heat shock protein Hsp70
3308HSP74_HUMANP34932IPR013126Hsp_70Heat shock protein 70

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