Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3309
Official Symbol:HSPA5
Other Aliases:BIP|FLJ26106|GRP78|MIF2
See related:HGNC:5238|MIM:138120|HPRD:00682
Chromosome:9
Location:9q33-q34.1
Gene Description:heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0408
ORGANISM:human
Entrez Gene ID:3309
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:25617
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0088
ORGANISM:human
Entrez Gene ID:3309
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15009677
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Upregulated
Fold Change:0.41 :: -0.24 :: -0.68 :: 1.02 :: 0.54 :: 0.24 :: -0.25 :: 0.39 :: -0.47 :: 0.52
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14828CBCerebellum90.7902069091797100.0
14828CTXCerebral cortex100.0100.0
14828HIPHippocampal region100.0100.0
14828HPFHippocampal formation100.0100.0
14828HYHypothalamus100.0100.0
14828LSXLateral septal complex100.0100.0
14828MBMidbrain100.0100.0
14828MYMedulla100.0100.0
14828OLFOlfactory bulb100.0100.0
14828PPons100.0100.0
14828PALPallidum100.0100.0
14828RHPRetrohippocampal region100.0100.0
14828sAMYStriatum-like amygdalar nuclei100.0100.0
14828STRStriatum100.0100.0
14828STRdStriatum dorsal region100.0100.0
14828STRvStriatum ventral region100.0100.0
14828THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3309GO:0000166IEAFunctionnucleotide binding
3309GO:0005509TASFunctioncalcium ion binding
3309GO:0005524NASFunctionATP binding
3309GO:0005634IDAComponentnucleus
3309GO:0005788TASComponentendoplasmic reticulum lumen
3309GO:0005793IDAComponentER-Golgi intermediate compartment
3309GO:0006916IMPProcessanti-apoptosis
3309GO:0006916TASProcessanti-apoptosis
3309GO:0008303IDAComponentcaspase complex
3309GO:0009986IEPComponentcell surface
3309GO:0030176IDAComponentintegral to endoplasmic reticulum membrane
3309GO:0030674NASFunctionprotein binding, bridging
3309GO:0043027IDAFunctioncaspase inhibitor activity
3309GO:0043154IDAProcessnegative regulation of caspase activity
3309GO:0048471IDAComponentperinuclear region
3309GO:0051082TASFunctionunfolded protein binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3507CAA34971.1unnamed protein productHPRD00912
-3875NP_000215.1keratin 18HPRD01020
-7253NP_000360.1thyroid stimulating hormone receptorHPRD04537
-3359NP_000860.15-hydroxytryptamine (serotonin) receptor 3A isoform b precursorHPRD08917
-3856NP_002264.1keratin 8HPRD01015
-3938NP_002290.2lactase-phlorizin hydrolase preproproteinHPRD04437
-7038NP_003226.3thyroglobulinHPRD01782
-9159NP_004707.2proprotein convertase subtilisin/kexin type 7 preproproteinHPRD05339
-10961NP_006808.1endoplasmic reticulum protein 29 isoform 1 precursorHPRD03794
-54972NP_060340.2transmembrane protein 132A isoform aHPRD11034
-64215NP_071760.2DnaJ (Hsp40) homolog, subfamily C, member 1HPRD09922
NP_005338.1--Ig Light ChainHPRD00682
NP_005338.1--Ig Heavy ChainHPRD00682
NP_005338.1--MHC class IHPRD00682
NP_005338.1--Caspase 12HPRD00682
NP_005338.1--ERdj5HPRD00682
NP_005338.1-AAL29687.1Measles virus G954 haemagglutinin (H) mRNA, complete cds.BIND19093
NP_005338.1-BAA88292.1L proteinBIND50161
NP_005338.13507-Immunoglobulin muHPRD00682
NP_005338.13856-Keratin 8HPRD00682
NP_005338.13875-Keratin 18HPRD00682
NP_005338.110961-ERP28HPRD00682
NP_005338.17038-ThyroglobulinHPRD00682
NP_005338.164215-HTJ1HPRD00682
NP_005338.19159-PCSK7HPRD00682
NP_005338.13938-LactaseHPRD00682
NP_005338.13359-Serotonin 5-HT-3 receptorHPRD00682
NP_005338.17253-Thyroid stimulating hormone receptorHPRD00682
NP_005338.16955AAH71758.1TRA@ proteinHPRD00682
NP_005338.16955AAH71758.1TRA@ proteinHPRD01736
NP_005338.15621NP_000302.1prion protein preproproteinBIND262185
NP_005338.17253NP_000360.1thyroid stimulating hormone receptorBIND19161
NP_005338.13949NP_000518.1low density lipoprotein receptor precursorHPRD06091
NP_005338.13949NP_000518.1low density lipoprotein receptor precursorHPRD00682
NP_005338.17450NP_000543.1von Willebrand factor precursorHPRD00682
NP_005338.17450NP_000543.1von Willebrand factor precursorHPRD01906
NP_005338.19451NP_004827.2eukaryotic translation initiation factor 2-alpha kinase 3HPRD04942
NP_005338.19451NP_004827.2eukaryotic translation initiation factor 2-alpha kinase 3HPRD00682
NP_005338.13925NP_005554.1stathmin 1HPRD00682
NP_005338.13925NP_005554.1stathmin 1HPRD01047
NP_005338.110915NP_006697.2transcription elongation regulator 1 isoform 1HPRD10393
NP_005338.123118NP_055908.1mitogen-activated protein kinase kinase kinase 7 interacting protein 2HPRD05483
NP_005338.154431NP_061854.1DnaJ (Hsp40) homolog, subfamily C, member 10HPRD09722
NP_005338.164374NP_071909.1SIL1 protein precursorHPRD12150
NP_005338.16885NP_663304.1mitogen-activated protein kinase kinase kinase 7 isoform BHPRD04011
NP_005338.11489800NP_056922.1fusion proteinBIND19098
NP_005338.1155030NP_057850.1Pr55(Gag)--
NP_005338.1155030NP_057850.1Pr55(Gag)--
NP_005338.1155807NP_057852.2Vpr--
NP_005338.1155871NP_057853.1Tat--
NP_005338.1155030NP_579876.2matrix--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3309GRP78_HUMANP11021IPR000886ER_target_SEndoplasmic reticulum targeting sequence
3309GRP78_HUMANP11021IPR001023Hsp70Heat shock protein Hsp70
3309GRP78_HUMANP11021IPR013126Hsp_70Heat shock protein 70

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