Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3312
Official Symbol:HSPA8
Other Aliases:HSC54|HSC70|HSC71|HSP71|HSP73|HSPA10|LAP1|MGC131511|MGC29929|NIP71
See related:HGNC:5241|MIM:600816|HPRD:07205
Chromosome:11
Location:11q24.1
Gene Description:heat shock 70kDa protein 8
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIP0198
ORGANISM:human
Entrez Gene ID:3312
Evidence Type:Proteomics
Evidence ID Type:PUBMED
Evidence ID:15542695
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Whole Brain
Drug Effects:Upregulated
Fold Change:6.50
KARG Evidence 2
KARG ID:EVIP0218
ORGANISM:human
Entrez Gene ID:3312
Evidence Type:Proteomics
Evidence ID Type:PUBMED
Evidence ID:15542695
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Whole Brain
Drug Effects:Downregulated
Fold Change:0.21
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3312GO:0000166IEAFunctionnucleotide binding
3312GO:0005524IEAFunctionATP binding
3312GO:0005634IEAComponentnucleus
3312GO:0006457NASProcessprotein folding
3312GO:0006986NASProcessresponse to unfolded protein
3312GO:0009986IEPComponentcell surface
3312GO:0042623NASFunctionATPase activity, coupled
3312GO:0051082IEAFunctionunfolded protein binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-27000CAA66913.1M-phase phosphoprotein 11BIND215373
-7157NP_000537.2tumor protein p53BIND295903
-7157NP_000537.2tumor protein p53BIND295866
-7132NP_001056.1tumor necrosis factor receptor 1 precursorHPRD01861
-9531NP_004272.2BCL2-associated athanogene 3HPRD04860
-9532NP_004273.1BCL2-associated athanogene 2HPRD04859
-3717NP_004963.1Janus kinase 2HPRD00993
-5481NP_005029.1peptidylprolyl isomerase DHPRD11875
-3320NP_005339.1heat shock 90kDa protein 1, alphaHPRD00777
-10273NP_005852.1STIP1 homology and U-Box containing protein 1HPRD06232
-10808NP_006635.2heat shock 105kDHPRD09990
-54205NP_061820.1cytochrome cHPRD00479
-6667NP_612482.2Sp1 transcription factorHPRD01796
NP_006588.1--MAP3K1HPRD07205
NP_006588.154205-Cytochrome CHPRD07205
NP_006588.13320-HSP90AHPRD07205
NP_006588.110808-Heat shock protein 105 kDaHPRD07205
NP_006588.19531-BCL2 associated athanogene 3HPRD07205
NP_006588.19532-BCL2 associated athanogene 2HPRD07205
NP_006588.110273-STIP1 homologous and U box containing protein 1HPRD07205
NP_006588.16667-Transcription factor Sp1HPRD07205
NP_006588.13717-Janus kinase 2HPRD07205
NP_006588.19093-TID 1HPRD07205
NP_006588.17132-Tumor necrosis factor receptor 1HPRD07205
NP_006588.15481-Peptidyl-prolyl isomerase DHPRD07205
NP_006588.15925NP_000312.1retinoblastoma 1HPRD07205
NP_006588.17133NP_001057.1tumor necrosis factor receptor 2 precursorHPRD07205
NP_006588.13551NP_001547.1inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase betaHPRD07205
NP_006588.14215NP_002392.1MAP/ERK kinase kinase 3HPRD07205
NP_006588.14791NP_002493.2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)HPRD07205
NP_006588.14793NP_002494.2nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta isoform aHPRD07205
NP_006588.15966NP_002899.1v-rel reticuloendotheliosis viral oncogene homologHPRD07205
NP_006588.15966NP_002899.1v-rel reticuloendotheliosis viral oncogene homologHPRD01286
NP_006588.18517NP_003630.1inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gammaHPRD07205
NP_006588.18717NP_003780.1TNFRSF1A-associated via death domain isoform 1HPRD04610
NP_006588.18717NP_003780.1TNFRSF1A-associated via death domain isoform 1HPRD07205
NP_006588.18737NP_003795.1receptor (TNFRSF)-interacting serine-threonine kinase 1HPRD07205
NP_006588.18767NP_003812.1receptor-interacting serine-threonine kinase 2HPRD07205
NP_006588.18841NP_003874.2histone deacetylase 3HPRD07205
NP_006588.19020NP_003945.1mitogen-activated protein kinase kinase kinase 14HPRD07205
NP_006588.14790NP_003989.1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)HPRD07205
NP_006588.14435NP_004134.1Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1HPRD07205
NP_006588.14435NP_004134.1Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1HPRD02146
NP_006588.110010NP_004171.2TRAF interacting protein TANK isoform aHPRD07205
NP_006588.14794NP_004547.1nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilonHPRD07205
NP_006588.110006NP_005461.1abl-interactor 1HPRD07205
NP_006588.13925NP_005554.1stathmin 1HPRD07205
NP_006588.13925NP_005554.1stathmin 1HPRD01047
NP_006588.17185NP_005649.1TNF receptor-associated factor 1HPRD07205
NP_006588.110273NP_005852.1STIP1 homology and U-Box containing protein 1BIND153533
NP_006588.17203NP_005989.2chaperonin containing TCP1, subunit 3 (gamma)HPRD08969
NP_006588.17203NP_005989.2chaperonin containing TCP1, subunit 3 (gamma)HPRD07205
NP_006588.110454NP_006107.1mitogen-activated protein kinase kinase kinase 7 interacting protein 1 isoform alphaHPRD07205
NP_006588.13337NP_006136.1DnaJ (Hsp40) homolog, subfamily B, member 1BIND153534
NP_006588.15971NP_006500.2reticuloendotheliosis viral oncogene homolog BHPRD07205
NP_006588.110915NP_006697.2transcription elongation regulator 1 isoform 1HPRD07205
NP_006588.110915NP_006697.2transcription elongation regulator 1 isoform 1HPRD10393
NP_006588.110971NP_006817.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, theta polypeptideHPRD07205
NP_006588.111035NP_006862.2receptor-interacting serine-threonine kinase 3HPRD07205
NP_006588.123640NP_036399.2hsp70-interacting proteinHPRD09991
NP_006588.123640NP_036399.2hsp70-interacting proteinHPRD07205
NP_006588.129110NP_037386.1TANK-binding kinase 1HPRD07205
NP_006588.19641NP_054721.1IKK-related kinase epsilonHPRD07205
NP_006588.123118NP_055908.1mitogen-activated protein kinase kinase kinase 7 interacting protein 2HPRD07205
NP_006588.123118NP_055908.1mitogen-activated protein kinase kinase kinase 7 interacting protein 2HPRD05483
NP_006588.14792NP_065390.1nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alphaHPRD07205
NP_006588.17186NP_066961.2TNF receptor-associated factor 2HPRD07205
NP_006588.15970NP_068810.1v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65HPRD07205
NP_006588.16885NP_663304.1mitogen-activated protein kinase kinase kinase 7 isoform BHPRD04011
NP_006588.16885NP_663304.1mitogen-activated protein kinase kinase kinase 7 isoform BHPRD07205
NP_006588.17189NP_665802.1TNF receptor-associated factor 6HPRD07205
NP_006588.1155030NP_057850.1Pr55(Gag)--
NP_006588.1155807NP_057852.2Vpr--
NP_006588.1155871NP_057853.1Tat--
NP_006588.1155030NP_579876.2matrix--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3312HSP7C_HUMANP11142IPR001023Hsp70Heat shock protein Hsp70
3312HSP7C_HUMANP11142IPR013126Hsp_70Heat shock protein 70

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