Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3316
Official Symbol:HSPB2
Other Aliases:HSP27|Hs.78846|MGC133245|MKBP
See related:HGNC:5247|MIM:602179|HPRD:03712
Chromosome:11
Location:11q22-q23
Gene Description:heat shock 27kDa protein 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0143
ORGANISM:human
Entrez Gene ID:3316
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:69253
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:QTL0134
ORGANISM:human
Entrez Gene ID:3316
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:QTL0135
ORGANISM:human
Entrez Gene ID:3316
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 4
KARG ID:QTL0136
ORGANISM:human
Entrez Gene ID:3316
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
69253CBCerebellum0.00.0
69253CTXCerebral cortex0.00.0
69253HIPHippocampal region0.00.0
69253HPFHippocampal formation0.00.0
69253HYHypothalamus0.00.0
69253LSXLateral septal complex0.00.0
69253MBMidbrain0.00.0
69253MYMedulla0.00.0
69253OLFOlfactory bulb0.00.0
69253PPons0.00.0
69253PALPallidum0.00.0
69253RHPRetrohippocampal region0.00.0
69253sAMYStriatum-like amygdalar nuclei0.00.0
69253STRStriatum0.00.0
69253STRdStriatum dorsal region0.00.0
69253STRvStriatum ventral region0.00.0
69253THThalamus0.00.0
KARG Evidence 5
KARG ID:QTL0134
Trait:cocaine related behavior
Peak:29
Peak Marker:D9Mit4
Parents:BXD/Ty (B = C57BL/6, D = DBA/2) recombinant inbred
Evidence ID:10591541
KARG Evidence 6
KARG ID:QTL0135
Trait:ethanol consumption
Peak:29
Peak Marker:D9Mit4
Parents:B6D2F2 (C57BL/6J x DBA/2J) and BXD Recombinant Inbred
Evidence ID:11707775; 9880656
KARG Evidence 7
KARG ID:QTL0136
Trait:Chronic ethanol withdrawal
Peak:29
Peak Marker:D9Mit4
Parents:B6D2F2 (C57BL/6J x DBA/2J)
Evidence ID:11919667
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3316GO:0005515IPIFunctionprotein binding
3316GO:0005829TASComponentcytosol
3316GO:0006457IEAProcessprotein folding
3316GO:0006986NASProcessresponse to unfolded protein
3316GO:0008047TASFunctionenzyme activator activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_001532.18988NP_006299.1heat shock 27kDa protein 3HPRD03712
NP_001532.18988NP_006299.1heat shock 27kDa protein 3HPRD06861
NP_001532.157396NP_065717.1CDC-like kinase 4HPRD12140
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3316HSPB2_HUMANQ16082IPR001436Crystallin_alphaAlpha crystallin
3316HSPB2_HUMANQ16082IPR002068Hsp20Heat shock protein Hsp20

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