Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3329
Official Symbol:HSPD1
Other Aliases:CPN60|GROEL|HSP60|HSP65|HuCHA60|SPG13
See related:HGNC:5261|MIM:118190|HPRD:00318
Chromosome:2
Location:2q33.1
Gene Description:heat shock 60kDa protein 1 (chaperonin)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0969
ORGANISM:human
Entrez Gene ID:3329
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:1.4 :: 1.2 :: -1.8 :: -1.8
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3329GO:0000166IEAFunctionnucleotide binding
3329GO:0005515IEAFunctionprotein binding
3329GO:0005524IEAFunctionATP binding
3329GO:0005524NASFunctionATP binding
3329GO:0005739TASComponentmitochondrion
3329GO:0006457NASProcessprotein folding
3329GO:0006986NASProcessresponse to unfolded protein
3329GO:0030150NASProcessprotein import into mitochondrial matrix
3329GO:0042981TASProcessregulation of apoptosis
3329GO:0044267IEAProcesscellular protein metabolism
3329GO:0051082TASFunctionunfolded protein binding
3329GO:0051087IPIFunctionchaperone binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_002147.2--p21rasHPRD00318
NP_002147.2--PKA CHPRD00318
NP_002147.2--Alpha 3 beta 1 integrinHPRD00318
NP_002147.25621NP_000302.1prion protein preproproteinBIND153489
NP_002147.23336NP_002148.1heat shock 10kDa protein 1 (chaperonin 10)HPRD02535
NP_002147.23336NP_002148.1heat shock 10kDa protein 1 (chaperonin 10)HPRD00318
NP_002147.25921NP_002881.1RAS p21 protein activator 1 isoform 1HPRD00745
NP_002147.28349NP_003519.1H2B histone family, member QHPRD03494
NP_002147.28349NP_003519.1H2B histone family, member QHPRD00318
NP_002147.2155030NP_057850.1Pr55(Gag)--
NP_002147.2155348NP_705928.1integrase--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3329CH60_HUMANP10809IPR001844Chaprnin_Cpn60Chaperonin Cpn60
3329CH60_HUMANP10809IPR002423Cpn60/TCP-1Chaperonin Cpn60/TCP-1

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