Knowledgebase for Addiction-Related Genes
Home | Score | Chromosome | Pathway | Advanced Search | BLAST Search | Downloads | Publications | FAQ & Help |   

KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3351
Official Symbol:HTR1B
Other Aliases:5-HT1B|5-HT1DB|HTR1D2|HTR1DB|S12
See related:HGNC:5287|MIM:182131|HPRD:01634
Chromosome:6
Location:6q13
Gene Description:5-hydroxytryptamine (serotonin) receptor 1B
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0263
ORGANISM:human
Entrez Gene ID:3351
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:15551
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIL0142
ORGANISM:human
Entrez Gene ID:3351
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:15581469
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:EVIL0211
ORGANISM:human
Entrez Gene ID:3351
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:16344719
Addiction Drug:OPIOIDS
Addiction Drug Detail:HEROIN ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 4
KARG ID:EVID0015
ORGANISM:human
Entrez Gene ID:3351
Evidence Type:Database Annotations
Evidence ID Type:OMIM
Evidence ID:MIM:182131
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 5
KARG ID:QTL0148
ORGANISM:human
Entrez Gene ID:3351
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
15551CBCerebellum17.37641048431430.8168849945068
15551CTXCerebral cortex1.099804341793060.899633944034576
15551HIPHippocampal region4.295703649520873.01599287986755
15551HPFHippocampal formation3.871190071105962.6717689037323
15551HYHypothalamus1.772393226623541.5035896897316
15551LSXLateral septal complex7.180995225906374.59935808181763
15551MBMidbrain2.024025559425351.87807494401932
15551MYMedulla2.553263068199162.85617411136627
15551OLFOlfactory bulb1.338731765747071.12494924664497
15551PPons2.257761001586912.69563448429108
15551PALPallidum2.718613982200622.14229518175125
15551RHPRetrohippocampal region3.161907196044922.22763097286224
15551sAMYStriatum-like amygdalar nuclei4.091498732566832.97242498397827
15551STRStriatum26.647193908691417.9387431144714
15551STRdStriatum dorsal region32.228771209716821.8911542892456
15551STRvStriatum ventral region25.578759193420417.2126822471619
15551THThalamus0.5840871930122380.599387213587761
KARG Evidence 6
KARG ID:QTL0148
Trait:ethanol withdrawal
Peak:46
Peak Marker:D9Ncvs40
Parents:C57BL/6J x DBA/2J intercross
Evidence ID:9655868
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3351GO:0001584IEAFunctionrhodopsin-like receptor activity
3351GO:0004872IEAFunctionreceptor activity
3351GO:0004993TASFunctionserotonin receptor activity
3351GO:0005887TASComponentintegral to plasma membrane
3351GO:0007165IEAProcesssignal transduction
3351GO:0007187TASProcessG-protein signaling, coupled to cyclic nucleotide second messenger
3351GO:0007268TASProcesssynaptic transmission
3351GO:0016020IEAComponentmembrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3352NP_000855.15-hydroxytryptamine (serotonin) receptor 1DHPRD01636
NP_000854.13352-Serotonin 1D receptorHPRD01634
NP_000854.13351NP_000854.15-hydroxytryptamine (serotonin) receptor 1BHPRD01634
NP_000854.13351NP_000854.15-hydroxytryptamine (serotonin) receptor 1BBIND215432
NP_000854.13352NP_000855.15-hydroxytryptamine (serotonin) receptor 1DBIND216546
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
33515HT1B_HUMANP28222IPR0021475HT1B_rcpt5-Hydroxytryptamine 1B receptor
33515HT1B_HUMANP28222IPR0022315HT_rcpt5-Hydroxytryptamine receptor
33515HT1B_HUMANP28222IPR002233Adrnrgc_rcptAdrenergic receptor
33515HT1B_HUMANP28222IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
33515HT1B_HUMANP28222IPR000995Musac_rcptMuscarinic acetylcholine receptor
33515HT1B_HUMANP28222IPR000611NPY_rcptNeuropeptide Y receptor

© Center for Bioinformatics(CBI), Peking University
Any Comments and suggestions to : KARG GROUP.