Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3356
Official Symbol:HTR2A
Other Aliases:5-HT2A|HTR2
See related:HGNC:5293|MIM:182135|HPRD:01638
Chromosome:13
Location:13q14-q21
Gene Description:5-hydroxytryptamine (serotonin) receptor 2A
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIL0119
ORGANISM:human
Entrez Gene ID:3356
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:15211639
Addiction Drug:NICOTINE
Addiction Drug Detail:NICOTINE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVID0016
ORGANISM:human
Entrez Gene ID:3356
Evidence Type:Database Annotations
Evidence ID Type:OMIM
Evidence ID:MIM:182135
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
15558CBCerebellum1.127283602952961.63643777370453
15558CTXCerebral cortex0.5454241931438450.433936461806297
15558HIPHippocampal region0.1594129242002960.230692751705647
15558HPFHippocampal formation0.342742480337620.324985973536968
15558HYHypothalamus0.3160085231065750.301963612437248
15558LSXLateral septal complex0.1645741406828170.113874023780227
15558MBMidbrain0.2296589016914370.339673191308975
15558MYMedulla0.3054612949490550.411473974585533
15558OLFOlfactory bulb0.7170713692903520.542132556438446
15558PPons0.2972753271460530.31344947218895
15558PALPallidum0.1517857983708380.146026814356446
15558RHPRetrohippocampal region0.5931985937058930.394423920661211
15558sAMYStriatum-like amygdalar nuclei0.1678569763898850.339349754154682
15558STRStriatum0.2365298420190810.205571185797453
15558STRdStriatum dorsal region0.1520211361348630.108329858630896
15558STRvStriatum ventral region0.6141549907624720.47975005581975
15558THThalamus0.1209606155753140.174130223691463
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3356GO:0001584IEAFunctionrhodopsin-like receptor activity
3356GO:0004872IEAFunctionreceptor activity
3356GO:0004993TASFunctionserotonin receptor activity
3356GO:0005887TASComponentintegral to plasma membrane
3356GO:0007165IEAProcesssignal transduction
3356GO:0007210TASProcessserotonin receptor signaling pathway
3356GO:0007268TASProcesssynaptic transmission
3356GO:0016020IEAComponentmembrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3717NP_004963.1Janus kinase 2HPRD00993
NP_000612.13717-Janus kinase 2HPRD01638
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
33565HT2A_HUMANP28223IPR0004555HT2A_rcpt5-Hydroxytryptamine 2A receptor
33565HT2A_HUMANP28223IPR0022325HT6_rcpt5-Hydroxytryptamine 6 receptor
33565HT2A_HUMANP28223IPR0022315HT_rcpt5-Hydroxytryptamine receptor
33565HT2A_HUMANP28223IPR000929Dopamine_rcptDopamine receptor
33565HT2A_HUMANP28223IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily

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