Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3358
Official Symbol:HTR2C
Other Aliases:5-HT2C|HTR1C
See related:HGNC:5295|MIM:312861|HPRD:02429
Chromosome:X
Location:Xq24
Gene Description:5-hydroxytryptamine (serotonin) receptor 2C
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0602
ORGANISM:human
Entrez Gene ID:3358
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:25187
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
15560CBCerebellum9.9372899532318116.3362069129944
15560CTXCerebral cortex12.463797569274912.5384321212769
15560HIPHippocampal region11.295441627502416.3063788414001
15560HPFHippocampal formation14.604488849639919.7551517486572
15560HYHypothalamus33.947942733764634.6792936325073
15560LSXLateral septal complex47.696048736572354.8958301544189
15560MBMidbrain57.272527694702165.923397064209
15560MYMedulla44.617128372192460.1279926300049
15560OLFOlfactory bulb41.31398582458547.4628276824951
15560PPons38.770235061645546.8803024291992
15560PALPallidum34.375655174255436.6441688537598
15560RHPRetrohippocampal region19.633884429931623.9383363723755
15560sAMYStriatum-like amygdalar nuclei66.070672988891672.0705871582031
15560STRStriatum27.792227745056227.1935262680054
15560STRdStriatum dorsal region10.60979604721079.76558470726013
15560STRvStriatum ventral region55.63168525695846.4405708312988
15560THThalamus23.203943252563528.1992063522339
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3358GO:0001584IEAFunctionrhodopsin-like receptor activity
3358GO:0004872IEAFunctionreceptor activity
3358GO:0004993NRFunctionserotonin receptor activity
3358GO:0005887NRComponentintegral to plasma membrane
3358GO:0007165IEAProcesssignal transduction
3358GO:0007210NRProcessserotonin receptor signaling pathway
3358GO:0007268TASProcesssynaptic transmission
3358GO:0007631TASProcessfeeding behavior
3358GO:0016020IEAComponentmembrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-55327NP_060832.1lin-7 homolog CHPRD17279
NP_000859.1--MPDZHPRD02429
NP_000859.1--MUPP1HPRD02429
NP_000859.1--Gq alphaHPRD02429
NP_000859.1--Veli3HPRD02429
NP_000859.1--Gq ProteinsHPRD02429
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
33585HT2C_HUMANP28335IPR0003775HT2C_rcpt5-Hydroxytryptamine 2C receptor
33585HT2C_HUMANP28335IPR0022325HT6_rcpt5-Hydroxytryptamine 6 receptor
33585HT2C_HUMANP28335IPR0022315HT_rcpt5-Hydroxytryptamine receptor
33585HT2C_HUMANP28335IPR000929Dopamine_rcptDopamine receptor
33585HT2C_HUMANP28335IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily

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