Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3363
Official Symbol:HTR7
Other Aliases:5-HT7
See related:HGNC:5302|MIM:182137|HPRD:01639
Chromosome:10
Location:10q21-q24
Gene Description:5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:QTL0257
ORGANISM:human
Entrez Gene ID:3363
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
15566CBCerebellum1.588707327842711.57351338863373
15566CTXCerebral cortex0.364267170429230.435568302869797
15566HIPHippocampal region0.320493489503860.313545495271683
15566HPFHippocampal formation0.3750864565372470.336808860301971
15566HYHypothalamus0.2059321105480190.331248462200165
15566LSXLateral septal complex0.00.0
15566MBMidbrain0.118179418146610.120590038597584
15566MYMedulla2.377439498901372.3312520980835
15566OLFOlfactory bulb2.277307033538822.92729735374451
15566PPons0.2041898369789120.207391679286957
15566PALPallidum0.5696642994880681.15592467784882
15566RHPRetrohippocampal region0.4598917365074160.35536515712738
15566sAMYStriatum-like amygdalar nuclei0.4421114325523380.717862129211426
15566STRStriatum0.3770318329334260.346972614526749
15566STRdStriatum dorsal region0.17776332795620.162663251161575
15566STRvStriatum ventral region1.10001206398010.703868806362152
15566THThalamus0.2297126501798630.315117418766022
KARG Evidence 2
KARG ID:QTL0257
Trait:Chronic ethanol withdrawal
Peak:33
Peak Marker:D19Mit13
Parents:B6D2F2 (C57BL/6J x DBA/2J)
Evidence ID:11919667
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3363GO:0001584IEAFunctionrhodopsin-like receptor activity
3363GO:0004872IEAFunctionreceptor activity
3363GO:0004977IEAFunctionmelanocortin receptor activity
3363GO:0004993TASFunctionserotonin receptor activity
3363GO:0005887TASComponentintegral to plasma membrane
3363GO:0007165IEAProcesssignal transduction
3363GO:0007186IEAProcessG-protein coupled receptor protein signaling pathway
3363GO:0007187TASProcessG-protein signaling, coupled to cyclic nucleotide second messenger
3363GO:0007268TASProcesssynaptic transmission
3363GO:0007623TASProcesscircadian rhythm
3363GO:0008015TASProcesscirculation
3363GO:0016020IEAComponentmembrane
3363GO:0016021IEAComponentintegral to membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_000863.1114928NP_001004051.1G protein-coupled receptor associated sorting protein 2BIND178804
NP_000863.19737NP_055525.1G protein-coupled receptor associated sorting protein 1BIND178702
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3363IPR0010695HT_7_rcpt5-Hydroxytryptamine 7 receptor
3363IPR0022315HT_rcpt5-Hydroxytryptamine receptor
3363IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
3363IPR001671Melcrt_ACTH_rcptMelanocortin/ACTH receptor
3363IPR000995Musac_rcptMuscarinic acetylcholine receptor
3363IPR000611NPY_rcptNeuropeptide Y receptor
33635HT7R_HUMANP34969IPR0010695HT_7_rcpt5-Hydroxytryptamine 7 receptor
33635HT7R_HUMANP34969IPR0022315HT_rcpt5-Hydroxytryptamine receptor
33635HT7R_HUMANP34969IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
33635HT7R_HUMANP34969IPR001671Melcrt_ACTH_rcptMelanocortin/ACTH receptor
33635HT7R_HUMANP34969IPR000995Musac_rcptMuscarinic acetylcholine receptor
33635HT7R_HUMANP34969IPR000611NPY_rcptNeuropeptide Y receptor

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