Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3428
Official Symbol:IFI16
Other Aliases:IFNGIP1|PYHIN2
See related:HGNC:5395|MIM:147586|HPRD:00969
Chromosome:1
Location:1q22
Gene Description:interferon, gamma-inducible protein 16
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0856
ORGANISM:human
Entrez Gene ID:3428
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.6 :: -1.4
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3428GO:0003676IEAFunctionnucleic acid binding
3428GO:0003677IEAFunctionDNA binding
3428GO:0003690IDAFunctiondouble-stranded DNA binding
3428GO:0005515IDAFunctionprotein binding
3428GO:0005634IDAComponentnucleus
3428GO:0005654IDAComponentnucleoplasm
3428GO:0005730IDAComponentnucleolus
3428GO:0006350IEAProcesstranscription
3428GO:0006355NASProcessregulation of transcription, DNA-dependent
3428GO:0006955IEAProcessimmune response
3428GO:0008283NASProcesscell proliferation
3428GO:0009615NASProcessresponse to virus
3428GO:0016564IDAFunctiontranscriptional repressor activity
3428GO:0030224IDAProcessmonocyte differentiation
3428GO:0042771IDAProcessDNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7157NP_000537.2tumor protein p53HPRD01859
NP_005522.17157-p53HPRD00969
NP_005522.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3428IPR004021HIN200/IF120xHIN-200/IF120x
3428IPR004020PAAD_DAPINPyrin

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