Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3479
Official Symbol:IGF1
Other Aliases:IGFI
See related:HGNC:5464|MIM:147440
Chromosome:12
Location:12q22-q23
Gene Description:insulin-like growth factor 1 (somatomedin C)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0187
ORGANISM:human
Entrez Gene ID:3479
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15312160
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
16000CBCerebellum1.141482710838321.21016454696655
16000CTXCerebral cortex1.291930437088010.798928320407867
16000HIPHippocampal region1.070211291313171.19693696498871
16000HPFHippocampal formation0.8555510640144350.806036770343781
16000HYHypothalamus0.3567436039447780.507166504859924
16000LSXLateral septal complex0.2044473588466640.126888051629066
16000MBMidbrain0.5787988901138310.489200949668884
16000MYMedulla3.044180631637572.46314787864685
16000OLFOlfactory bulb7.116222858428965.40547227859497
16000PPons1.35915362834930.956966459751129
16000PALPallidum0.4685457646846770.789985358715057
16000RHPRetrohippocampal region0.5293756127357480.294184774160385
16000sAMYStriatum-like amygdalar nuclei0.04649676010012630.0
16000STRStriatum0.3236023783683780.631523847579956
16000STRdStriatum dorsal region0.3043022155761720.721612572669983
16000STRvStriatum ventral region0.7014962434768681.0385080575943
16000THThalamus0.2727464139461520.2907794713974
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3479GO:0001501TASProcessskeletal development
3479GO:0005159TASFunctioninsulin-like growth factor receptor binding
3479GO:0005179TASFunctionhormone activity
3479GO:0005576IEAComponentextracellular region
3479GO:0005576NASComponentextracellular region
3479GO:0006260TASProcessDNA replication
3479GO:0006928TASProcesscell motility
3479GO:0007165TASProcesssignal transduction
3479GO:0007265TASProcessRas protein signal transduction
3479GO:0007517TASProcessmuscle development
3479GO:0007582IEAProcessphysiological process
3479GO:0007605IEAProcesssensory perception of sound
3479GO:0008083IEAFunctiongrowth factor activity
3479GO:0008284TASProcesspositive regulation of cell proliferation
3479GO:0009441TASProcessglycolate metabolism
3479GO:0018445IEAFunctionprothoracicotrophic hormone activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3488NP_000590.1insulin-like growth factor binding protein 5HPRD00901
-3547NP_001546.1immunoglobulin superfamily, member 1HPRD02138
-3547NP_001546.1immunoglobulin superfamily, member 1HPRD02138
AAA52539.13488-IGF binding protein 5HPRD00936
AAA52539.13547-Immunoglobulin superfamily member 1HPRD00936
AAA52539.13484NP_000587.1insulin-like growth factor binding protein 1 isoform a precursorHPRD00936
AAA52539.13484NP_000587.1insulin-like growth factor binding protein 1 isoform a precursorHPRD00897
AAA52539.13485NP_000588.1insulin-like growth factor binding protein 2 (36kD)HPRD00936
AAA52539.13485NP_000588.1insulin-like growth factor binding protein 2 (36kD)HPRD00898
AAA52539.13486NP_000589.1insulin-like growth factor binding protein 3HPRD00936
AAA52539.13486NP_000589.1insulin-like growth factor binding protein 3HPRD00899
AAA52539.13480NP_000866.1insulin-like growth factor 1 receptor precursorHPRD00932
AAA52539.13480NP_000866.1insulin-like growth factor 1 receptor precursorHPRD00936
AAA52539.13487NP_001543.1insulin-like growth factor binding protein 4HPRD00936
AAA52539.13487NP_001543.1insulin-like growth factor binding protein 4HPRD00900
AAA52539.13490NP_001544.1insulin-like growth factor binding protein 7HPRD04183
AAA52539.13490NP_001544.1insulin-like growth factor binding protein 7HPRD00936
AAA52539.13489NP_002169.1insulin-like growth factor binding protein 6HPRD00936
AAA52539.13489NP_002169.1insulin-like growth factor binding protein 6HPRD00902
AAA52539.14856NP_002505.1nov precursorHPRD01291
AAA52539.14856NP_002505.1nov precursorHPRD00936
AAA52539.13483NP_004961.1insulin-like growth factor binding protein, acid labile subunitHPRD03290
AAA52539.13483NP_004961.1insulin-like growth factor binding protein, acid labile subunitHPRD00936
NP_000609.13484NP_000587.1insulin-like growth factor binding protein 1 isoform a precursorBIND146563
NP_000609.13485NP_000588.1insulin-like growth factor binding protein 2 (36kD)BIND146559
NP_000609.13486NP_000589.1insulin-like growth factor binding protein 3BIND146560
NP_000609.13488NP_000590.1insulin-like growth factor binding protein 5BIND146561
NP_000609.13480NP_000866.1insulin-like growth factor 1 receptor precursorBIND182763
NP_000609.13487NP_001543.1insulin-like growth factor binding protein 4BIND146564
NP_000609.13489NP_002169.1insulin-like growth factor binding protein 6BIND146562
NP_000609.1155871NP_057853.1Tat--
NP_000609.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3479IGF1A_HUMANP01343IPR013576IGF2_CInsulin-like growth factor II E-peptide, C-terminal
3479IGF1A_HUMANP01343IPR004825Ins/IGF/relaxInsulin/IGF/relaxin

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