Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:348
Official Symbol:APOE
Other Aliases:AD2|MGC1571|apoprotein
See related:HGNC:613|MIM:107741|HPRD:00135
Chromosome:19
Location:19q13.2
Gene Description:apolipoprotein E
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0118
ORGANISM:human
Entrez Gene ID:348
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:11816
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0830
ORGANISM:human
Entrez Gene ID:348
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.3 :: -1.6 :: -1.3 :: -1.6
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11816CBCerebellum100.0100.0
11816CTXCerebral cortex100.0100.0
11816HIPHippocampal region100.0100.0
11816HPFHippocampal formation100.0100.0
11816HYHypothalamus100.0100.0
11816LSXLateral septal complex100.0100.0
11816MBMidbrain100.0100.0
11816MYMedulla100.0100.0
11816OLFOlfactory bulb100.0100.0
11816PPons100.0100.0
11816PALPallidum100.0100.0
11816RHPRetrohippocampal region100.0100.0
11816sAMYStriatum-like amygdalar nuclei100.0100.0
11816STRStriatum100.0100.0
11816STRdStriatum dorsal region100.0100.0
11816STRvStriatum ventral region100.0100.0
11816THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
348GO:0000302NASProcessresponse to reactive oxygen species
348GO:0001540IDAFunctionbeta-amyloid binding
348GO:0005319IEAFunctionlipid transporter activity
348GO:0005543TASFunctionphospholipid binding
348GO:0005576NASComponentextracellular region
348GO:0005576TASComponentextracellular region
348GO:0005737TASComponentcytoplasm
348GO:0006869TASProcesslipid transport
348GO:0006917IDAProcessinduction of apoptosis
348GO:0007010TASProcesscytoskeleton organization and biogenesis
348GO:0007271TASProcesssynaptic transmission, cholinergic
348GO:0007611TASProcesslearning and/or memory
348GO:0008015NASProcesscirculation
348GO:0008201NASFunctionheparin binding
348GO:0016209NASFunctionantioxidant activity
348GO:0030516TASProcessregulation of axon extension
348GO:0042157NASProcesslipoprotein metabolism
348GO:0042627IEAComponentchylomicron
348GO:0042632TASProcesscholesterol homeostasis
348GO:0046907TASProcessintracellular transport
348GO:0048156TASFunctiontau protein binding
348GO:0048168TASProcessregulation of neuronal synaptic plasticity
348GO:0050749NASFunctionapolipoprotein E receptor binding
348GO:0051262IDAProcessprotein tetramerization
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-4035NP_002323.1low density lipoprotein-related protein 1HPRD00138
-4036NP_004516.1low density lipoprotein-related protein 2HPRD02509
NP_000032.1--LamininHPRD00135
NP_000032.1--Beta-amyloidHPRD00135
NP_000032.1-CAB46677.1polyproteinBIND185110
NP_000032.14035-Low density lipoprotein receptor-related protein 1HPRD00135
NP_000032.14036-Low density lipoprotein related protein 2HPRD00135
NP_000032.1351NP_000475.1amyloid beta A4 protein precursor, isoform aHPRD00100
NP_000032.13949NP_000518.1low density lipoprotein receptor precursorHPRD06091
NP_000032.13949NP_000518.1low density lipoprotein receptor precursorHPRD00135
NP_000032.11270NP_000605.1ciliary neurotrophic factorBIND19224
NP_000032.11270NP_000605.1ciliary neurotrophic factorBIND17535
NP_000032.16383NP_002989.1syndecan 2HPRD00803
NP_000032.16383NP_002989.1syndecan 2HPRD00135
NP_000032.17436NP_003374.1very low density lipoprotein receptorHPRD01895
NP_000032.17436NP_003374.1very low density lipoprotein receptorHPRD00135
NP_000032.17804NP_004622.1low density lipoprotein receptor-related protein 8 isoform 1 precursorHPRD04002
NP_000032.17804NP_004622.1low density lipoprotein receptor-related protein 8 isoform 1 precursorHPRD00135
NP_000032.1949NP_005496.3scavenger receptor class B, member 1HPRD00135
NP_000032.1949NP_005496.3scavenger receptor class B, member 1HPRD03024
NP_000032.15360NP_006218.1phospholipid transfer protein isoform a precursorHPRD01399
NP_000032.15360NP_006218.1phospholipid transfer protein isoform a precursorHPRD00135
NP_000032.14137NP_058519.1microtubule-associated protein tau isoform 1HPRD01142
NP_000032.14137NP_058519.1microtubule-associated protein tau isoform 1HPRD00135
NP_000032.14133NP_114034.1microtubule-associated protein 2 isoform 3HPRD01140
NP_000032.14133NP_114034.1microtubule-associated protein 2 isoform 3HPRD00135
NP_000032.11508NP_680090.1cathepsin B preproproteinHPRD00287
NP_000032.11508NP_680090.1cathepsin B preproproteinHPRD00135
NP_000032.1951475NP_671491.1polyproteinBIND185107
NP_000032.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
348APOE_HUMANP02649IPR000074ApoA1_A4_EApolipoprotein A1/A4/E

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