Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3480
Official Symbol:IGF1R
Other Aliases:CD221|IGFIR|JTK13
See related:HGNC:5465|MIM:147370|HPRD:00932
Chromosome:15
Location:15q26.3
Gene Description:insulin-like growth factor 1 receptor
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0188
ORGANISM:human
Entrez Gene ID:3480
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15312160
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-
KARG Evidence 2
KARG ID:EVIM0424
ORGANISM:human
Entrez Gene ID:3480
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:1.1 :: -1.3 :: -1.8 :: -2.1 :: -1.4 :: -1.5
KARG Evidence 3
KARG ID:EVIM0492
ORGANISM:human
Entrez Gene ID:3480
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-1 :: 1 :: -1.3 :: -2.7 :: -1.5
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
16001CBCerebellum34.175891876220757.1545486450195
16001CTXCerebral cortex62.450634002685548.2999153137207
16001HIPHippocampal region35.784679412841851.3547782897949
16001HPFHippocampal formation32.359706878662138.138355255127
16001HYHypothalamus9.401373863220217.86908912658691
16001LSXLateral septal complex14.348305702209510.2013845443726
16001MBMidbrain27.680873870849624.8629856109619
16001MYMedulla32.823287963867235.0030555725098
16001OLFOlfactory bulb45.726005554199241.7659797668457
16001PPons24.002914428710924.0783462524414
16001PALPallidum10.93152046203618.90186214447021
16001RHPRetrohippocampal region25.753334045410220.5553398132324
16001sAMYStriatum-like amygdalar nuclei7.027923583984385.17492151260376
16001STRStriatum21.24597930908215.6261129379272
16001STRdStriatum dorsal region25.638553619384819.195987701416
16001STRvStriatum ventral region16.969211578369111.2979784011841
16001THThalamus70.482185363769566.6726684570312
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3480GO:0000074TASProcessregulation of progression through cell cycle
3480GO:0000166IEAFunctionnucleotide binding
3480GO:0004872IEAFunctionreceptor activity
3480GO:0005006IEAFunctionepidermal growth factor receptor activity
3480GO:0005010IDAFunctioninsulin-like growth factor receptor activity
3480GO:0005520IDAFunctioninsulin-like growth factor binding
3480GO:0005524IEAFunctionATP binding
3480GO:0005887ICComponentintegral to plasma membrane
3480GO:0006916TASProcessanti-apoptosis
3480GO:0007165TASProcesssignal transduction
3480GO:0008284TASProcesspositive regulation of cell proliferation
3480GO:0008286TASProcessinsulin receptor signaling pathway
3480GO:0016020IEAComponentmembrane
3480GO:0016740IEAFunctiontransferase activity
3480GO:0043548IPIFunctionphosphoinositide 3-kinase binding
3480GO:0043560IPIFunctioninsulin receptor substrate binding
3480GO:0046777IDAProcessprotein amino acid autophosphorylation
3480GO:0048009IDAProcessinsulin-like growth factor receptor signaling pathway
3480GO:0051262IDAProcessprotein tetramerization
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3486NP_000589.1insulin-like growth factor binding protein 3HPRD00899
-5921NP_002881.1RAS p21 protein activator 1 isoform 1HPRD00745
-7529NP_003395.1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptideHPRD03184
-7534NP_003397.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptideHPRD03183
-8660NP_003740.2insulin receptor substrate 2HPRD02878
-8835NP_003868.1suppressor of cytokine signaling-2HPRD05490
-3667NP_005535.1insulin receptor substrate 1HPRD00943
-10451NP_006104.3vav 3 oncogeneHPRD05706
-7531NP_006752.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptideHPRD05457
-10938NP_006786.2EH-domain containing 1HPRD09325
-4734NP_940682.1neural precursor cell expressed, developmentally down-regulated 4 isoform 2HPRD03786
NP_000866.1--IIP1HPRD00932
NP_000866.1--LARGHPRD00932
NP_000866.13667-IRS 1HPRD00932
NP_000866.15781-SHP2HPRD00932
NP_000866.15921-RasGAPHPRD00932
NP_000866.17531-14-3-3 epsilonHPRD00932
NP_000866.13486-IGF binding protein 3HPRD00932
NP_000866.17529-14-3-3 BetaHPRD00932
NP_000866.17534-14-3-3 zetaHPRD00932
NP_000866.18835-SOCS2HPRD00932
NP_000866.18660-IRS2HPRD00932
NP_000866.110451-VAV3HPRD00932
NP_000866.110938-EH domain containing 1HPRD00932
NP_000866.110399-RACK1HPRD00932
NP_000866.13688--BIND194826
NP_000866.14734-NEDD4HPRD00932
NP_000866.110135--BIND182761
NP_000866.13481AAA52443.1Human preproinsulin-like growth factor II (IGF-II) variant mRNA, and translated productsHPRD00939
NP_000866.13481AAA52443.1Human preproinsulin-like growth factor II (IGF-II) variant mRNA, and translated productsHPRD00932
NP_000866.13630NP_000198.1proinsulin precursorHPRD00932
NP_000866.13630NP_000198.1proinsulin precursorBIND182762
NP_000866.13480NP_000866.1insulin-like growth factor 1 receptor precursorHPRD00932
NP_000866.13716NP_002218.1janus kinase 1HPRD00992
NP_000866.13716NP_002218.1janus kinase 1HPRD00932
NP_000866.13716NP_002218.1janus kinase 1BIND153425
NP_000866.15587NP_002733.1protein kinase D1BIND194829
NP_000866.15770NP_002818.1protein tyrosine phosphatase, non-receptor type 1HPRD00932
NP_000866.16464NP_003020.2SHC (Src homology 2 domain containing) transforming protein 1 isoform p52ShcBIND12757
NP_000866.17529NP_003395.1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptideBIND12755
NP_000866.17534NP_003397.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptideBIND12756
NP_000866.18503NP_003620.1phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma)HPRD00932
NP_000866.18503NP_003620.1phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma)HPRD05831
NP_000866.18651NP_003736.1suppressor of cytokine signaling 1HPRD04669
NP_000866.18651NP_003736.1suppressor of cytokine signaling 1HPRD00932
NP_000866.18651NP_003736.1suppressor of cytokine signaling 1BIND12741
NP_000866.18660NP_003740.1insulin receptor substrate 2BIND12760
NP_000866.18835NP_003868.1suppressor of cytokine signaling-2BIND12740
NP_000866.18839NP_003872.1WNT1 inducible signaling pathway protein 2 precursorHPRD16020
NP_000866.19021NP_003946.3suppressor of cytokine signaling 3BIND12743
NP_000866.19342NP_004773.1synaptosomal-associated protein 29HPRD11968
NP_000866.15296NP_005018.1phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta)BIND12758
NP_000866.13667NP_005535.1insulin receptor substrate 1BIND45374
NP_000866.13667NP_005535.1insulin receptor substrate 1BIND197287
NP_000866.110399NP_006089.1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1BIND194822
NP_000866.15580NP_006245.2protein kinase C, deltaBIND194823
NP_000866.17531NP_006752.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptideBIND12751
NP_000866.110938NP_006786.2EH-domain containing 1BIND197297
NP_000866.123365NP_056128.1Rho guanine nucleotide exchange factor (GEF) 12HPRD09207
NP_000866.123365NP_056128.1Rho guanine nucleotide exchange factor (GEF) 12HPRD00932
NP_000866.155816NP_060901.2DOK5 protein isoform aHPRD16317
NP_000866.164599NP_072096.1PERQ amino acid rich, with GYF domain 1HPRD10145
NP_000866.164599NP_072096.1PERQ amino acid rich, with GYF domain 1HPRD00932
NP_000866.15295NP_852664.1phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 isoform 1HPRD00932
NP_000866.16464NP_892113.1SHC (Src homology 2 domain containing) transforming protein 1HPRD00932
NP_000866.16464NP_892113.1SHC (Src homology 2 domain containing) transforming protein 1HPRD02780
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3480IGF1R_HUMANP08069IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
3480IGF1R_HUMANP08069IPR000494EGF_rcpt_LEGF receptor, L domain
3480IGF1R_HUMANP08069IPR000463Fatty_acid_bdCytosolic fatty-acid binding
3480IGF1R_HUMANP08069IPR003962FnIII_subdFibronectin, type III subdomain
3480IGF1R_HUMANP08069IPR003961FN_IIIFibronectin, type III
3480IGF1R_HUMANP08069IPR006211Furin-likeFurin-like cysteine rich region
3480IGF1R_HUMANP08069IPR000719Prot_kinaseProtein kinase
3480IGF1R_HUMANP08069IPR002011RecepttyrkinsIIReceptor tyrosine kinase, class II
3480IGF1R_HUMANP08069IPR001245Tyr_pkinaseTyrosine protein kinase
3480IGF1R_HUMANP08069IPR008266Tyr_pkinase_ASTyrosine protein kinase, active site
3480IGF1R_HUMANP08069IPR013695WAKWall-associated kinase

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