Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:351
Official Symbol:APP
Other Aliases:AAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN2
See related:HGNC:620|MIM:104760|HPRD:00100
Chromosome:21
Location:21q21.2|21q21.3
Gene Description:amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0051
ORGANISM:human
Entrez Gene ID:351
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15009677
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Upregulated
Fold Change:0.23 :: 0.42 :: 0.27 :: -0.03 :: -0.10 :: -0.33 :: 0.53 :: 0.40 :: 0.42 :: 0.36
KARG Evidence 2
KARG ID:EVIM0350
ORGANISM:human
Entrez Gene ID:351
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:-0.81
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11820CBCerebellum50.050.0
11820CTXCerebral cortex50.050.0
11820HIPHippocampal region50.050.0
11820HPFHippocampal formation50.050.0
11820HYHypothalamus50.050.0
11820LSXLateral septal complex50.050.0
11820MBMidbrain50.050.0
11820MYMedulla50.050.0
11820OLFOlfactory bulb50.050.0
11820PPons50.050.0
11820PALPallidum50.050.0
11820RHPRetrohippocampal region50.050.0
11820sAMYStriatum-like amygdalar nuclei50.050.0
11820STRStriatum50.050.0
11820STRdStriatum dorsal region50.050.0
11820STRvStriatum ventral region50.050.0
11820THThalamus50.050.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
351GO:0004867IDAFunctionserine-type endopeptidase inhibitor activity
351GO:0004867NASFunctionserine-type endopeptidase inhibitor activity
351GO:0005506IEAFunctioniron ion binding
351GO:0005507IEAFunctioncopper ion binding
351GO:0005515IPIFunctionprotein binding
351GO:0005576TASComponentextracellular region
351GO:0005887TASComponentintegral to plasma membrane
351GO:0005905IEAComponentcoated pit
351GO:0006878TASProcesscopper ion homeostasis
351GO:0006897IEAProcessendocytosis
351GO:0006915IEAProcessapoptosis
351GO:0007155IEAProcesscell adhesion
351GO:0007219IEAProcessNotch signaling pathway
351GO:0008201IEAFunctionheparin binding
351GO:0008270IEAFunctionzinc ion binding
351GO:0009986IDAComponentcell surface
351GO:0016020IEAComponentmembrane
351GO:0046872IEAFunctionmetal ion binding
351GO:0050905NASProcessneuromuscular physiological process
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-8650AAD54279.1Homo sapiens NUMB isoform 1 (NUMB) mRNA, complete cds.HPRD04767
-2934NP_000168.1gelsolin isoform a precursorHPRD00674
-642NP_000377.1bleomycin hydrolaseHPRD03870
-2161NP_000496.1coagulation factor XII precursorHPRD01992
-3827NP_000884.1kininogen 1HPRD01970
-841NP_001219.2caspase 8 isoform AHPRD03459
-633NP_001702.1biglycan preproproteinHPRD02359
-1288NP_001838.1type IV alpha 6 collagen isoform A precursorHPRD02364
-3163NP_002125.3heme oxygenase (decyclizing) 2HPRD00783
-4035NP_002323.1low density lipoprotein-related protein 1HPRD00138
-3831NP_005543.1kinesin 2 60/70kDaHPRD02489
-10513NP_006371.2amyloid beta precursor protein-binding protein 2HPRD05616
-2192NP_006477.1fibulin 1 isoform DHPRD00629
-53358NP_058544.2src homology 2 domain containing transforming protein C3HPRD12005
-1600NP_066566.3disabled homolog 1HPRD04582
-1287NP_203699.1alpha 5 type IV collagen isoform 2, precursorHPRD02363
-10524NP_874369.1HIV-1 Tat interactive protein, 60kDa isoform 1HPRD03245
-6464NP_892113.1SHC (Src homology 2 domain containing) transforming protein 1HPRD02780
NP_000475.1--Collagen type IVHPRD00100
NP_000475.1--LamininHPRD00100
NP_000475.1--HumaninHPRD00100
NP_000475.1--F-spondinHPRD00100
NP_000475.1---BIND169418
NP_000475.1---BIND169425
NP_000475.14035-Low density lipoprotein receptor-related protein 1HPRD00100
NP_000475.1633-BiglycanHPRD00100
NP_000475.16464-SHCHPRD00100
NP_000475.11287-Collagen type IV, alpha 5HPRD00100
NP_000475.11288-Collagen type IV, alpha 6HPRD00100
NP_000475.16622-Synuclein alphaHPRD00100
NP_000475.1857-Caveolin 1HPRD00100
NP_000475.11600-Disabled-1HPRD00100
NP_000475.110513-PAT1HPRD00100
NP_000475.12934-GelsolinHPRD00100
NP_000475.11600-DAB1HPRD00100
NP_000475.1841-Caspase 8HPRD00100
NP_000475.1642-Bleomycin hydrolaseHPRD00100
NP_000475.123385-NicastrinHPRD00100
NP_000475.13831-Kinesin 2HPRD00100
NP_000475.12192-Fibulin 1HPRD00100
NP_000475.14811-Nidogen 1HPRD00100
NP_000475.13032-Hydroxyacyl dehydrogenase, subunit BHPRD00100
NP_000475.12161-Coagulation factor XIIHPRD00100
NP_000475.153358-SHC transforming protein 3HPRD00100
NP_000475.18650-NUMBHPRD00100
NP_000475.13163-Heme oxygenase 2HPRD00100
NP_000475.13827-KininogenHPRD00100
NP_000475.110524-HIV 1 Tat interacting proteinHPRD00100
NP_000475.17159CAC83012.1ASPP2 proteinHPRD11803
NP_000475.15663NP_000012.1presenilin 1HPRD00100
NP_000475.11278NP_000080.1alpha 2 type I collagenHPRD00100
NP_000475.11278NP_000080.1alpha 2 type I collagenHPRD00363
NP_000475.11285NP_000082.1alpha 3 type IV collagen isoform 1, precursorHPRD00100
NP_000475.11285NP_000082.1alpha 3 type IV collagen isoform 1, precursorHPRD00354
NP_000475.17040NP_000651.1transforming growth factor, beta 1BIND134111
NP_000475.1837NP_001216.1caspase 4 isoform alpha precursorHPRD04047
NP_000475.1837NP_001216.1caspase 4 isoform alpha precursorHPRD00100
NP_000475.11282NP_001836.1alpha 1 type IV collagen preproproteinHPRD00100
NP_000475.11282NP_001836.1alpha 1 type IV collagen preproproteinHPRD00359
NP_000475.11284NP_001837.1alpha 2 type IV collagen preproproteinHPRD00100
NP_000475.11284NP_001837.1alpha 2 type IV collagen preproproteinHPRD00355
NP_000475.12597NP_002037.2glyceraldehyde-3-phosphate dehydrogenaseHPRD00100
NP_000475.12597NP_002037.2glyceraldehyde-3-phosphate dehydrogenaseHPRD00713
NP_000475.12885NP_002077.1growth factor receptor-bound protein 2 isoform 1HPRD00100
NP_000475.15645NP_002761.1protease, serine, 2 preproproteinHPRD00100
NP_000475.15646NP_002762.2mesotrypsin preproproteinHPRD06685
NP_000475.15646NP_002762.2mesotrypsin preproproteinHPRD00100
NP_000475.16620NP_003076.1beta-synucleinHPRD00100
NP_000475.17042NP_003229.1transforming growth factor, beta 2BIND144417
NP_000475.18883NP_003896.1amyloid beta precursor protein-binding protein 1 isoform aHPRD00100
NP_000475.18883NP_003896.1amyloid beta precursor protein-binding protein 1 isoform aHPRD04545
NP_000475.18883NP_003896.1amyloid beta precursor protein-binding protein 1 isoform aBIND19149
NP_000475.1811NP_004334.1calreticulin precursorHPRD00100
NP_000475.13028NP_004484.1hydroxyacyl-Coenzyme A dehydrogenase, type II isoform 1HPRD00100
NP_000475.13028NP_004484.1hydroxyacyl-Coenzyme A dehydrogenase, type II isoform 1HPRD02223
NP_000475.19546NP_004877.1amyloid beta (A4) precursor protein-binding, family A, member 3HPRD05038
NP_000475.19546NP_004877.1amyloid beta (A4) precursor protein-binding, family A, member 3HPRD00100
NP_000475.13416NP_004960.1insulysinHPRD00100
NP_000475.19479NP_005447.1mitogen-activated protein kinase 8 interacting protein 1HPRD00100
NP_000475.13339NP_005520.2heparan sulfate proteoglycan 2HPRD00100
NP_000475.13339NP_005520.2heparan sulfate proteoglycan 2HPRD00804
NP_000475.1284217NP_005550.2laminin, alpha 1 precursorHPRD00100
NP_000475.110134NP_005736.3B-cell receptor-associated protein 31HPRD00100
NP_000475.110134NP_005736.3B-cell receptor-associated protein 31HPRD02319
NP_000475.110307NP_006042.2amyloid beta precursor protein-binding, family B, member 3 isoform dHPRD04089
NP_000475.110307NP_006042.2amyloid beta precursor protein-binding, family B, member 3 isoform dHPRD00100
NP_000475.110418NP_006099.1spondin 1, extracellular matrix proteinHPRD00100
NP_000475.110418NP_006099.1spondin 1, extracellular matrix proteinHPRD16087
NP_000475.122883NP_055759.2calsyntenin 1HPRD00100
NP_000475.122883NP_055759.2calsyntenin 1HPRD10837
NP_000475.153353NP_061027.1low density lipoprotein-related protein 1BHPRD00100
NP_000475.153353NP_061027.1low density lipoprotein-related protein 1BHPRD16383
NP_000475.183941NP_114416.1beta-amyloid binding protein precursorHPRD16540
NP_000475.183941NP_114416.1beta-amyloid binding protein precursorHPRD00100
NP_000475.184570NP_942014.1collagen, type XXV, alpha 1 isoform 1HPRD00100
NP_000475.184570NP_942014.1collagen, type XXV, alpha 1 isoform 1HPRD09886
NP_000475.1155871NP_057853.1Tat--
NP_958816.1---BIND169419
NP_958816.1---BIND169426
NP_958816.15664--BIND180464
NP_958816.15663--BIND181918
NP_958816.15663NP_000012.1presenilin 1BIND182618
NP_958816.15663NP_000012.1presenilin 1BIND180383
NP_958816.127429NP_037379.1HtrA serine peptidase 2 isoform 1 preproproteinBIND183538
NP_958816.1351NP_958816.1amyloid beta A4 protein precursor, isoform bBIND295312
NP_958817.1---BIND169420
NP_958817.1---BIND169427
NP_958817.15663NP_000012.1presenilin 1BIND182684
NP_958817.15663NP_000012.1presenilin 1BIND176637
NP_958817.19479NP_005447.1mitogen-activated protein kinase 8 interacting protein 1BIND148980
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
351IPR008155A4_APPAmyloidogenic glycoprotein
351IPR008154A4_extraAmyloid A4 extracellular region
351IPR001255Beta-APPBeta-amyloid peptide (beta-APP)
351IPR002223Prot_inh_Kunz-mProteinase inhibitor I2, Kunitz metazoa
351A4_HUMANP05067IPR008155A4_APPAmyloidogenic glycoprotein
351A4_HUMANP05067IPR008154A4_extraAmyloid A4 extracellular region
351A4_HUMANP05067IPR001255Beta-APPBeta-amyloid peptide (beta-APP)
351A4_HUMANP05067IPR002223Prot_inh_Kunz-mProteinase inhibitor I2, Kunitz metazoa

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