Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3551
Official Symbol:IKBKB
Other Aliases:IKK-beta|IKK2|IKKB|MGC131801|NFKBIKB
See related:HGNC:5960|MIM:603258|HPRD:04462
Chromosome:8
Location:8p11.2
Gene Description:inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0302
ORGANISM:human
Entrez Gene ID:3551
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Upregulated
Fold Change:0.59
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
16150CBCerebellum85.670578002929791.7400512695312
16150CTXCerebral cortex96.705959320068476.9839324951172
16150HIPHippocampal region83.183410644531276.9928016662598
16150HPFHippocampal formation87.384616851806681.6058120727539
16150HYHypothalamus59.954753875732442.6073503494263
16150LSXLateral septal complex28.665534019470217.3953375816345
16150MBMidbrain64.227453231811551.0062999725342
16150MYMedulla92.481662750244196.3970680236816
16150OLFOlfactory bulb100.092.0177116394043
16150PPons76.805185317993270.3606414794922
16150PALPallidum48.791343688964840.7967205047607
16150RHPRetrohippocampal region89.246284484863388.520866394043
16150sAMYStriatum-like amygdalar nuclei55.047378540039133.2389726638794
16150STRStriatum40.037194252014224.5383882522583
16150STRdStriatum dorsal region32.863466262817419.5633578300476
16150STRvStriatum ventral region65.174716949462940.8838319778442
16150THThalamus100.096.3053970336914
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3551GO:0000166IEAFunctionnucleotide binding
3551GO:0004674IEAFunctionprotein serine/threonine kinase activity
3551GO:0004674NASFunctionprotein serine/threonine kinase activity
3551GO:0004713IEAFunctionprotein-tyrosine kinase activity
3551GO:0005515IPIFunctionprotein binding
3551GO:0005524IEAFunctionATP binding
3551GO:0005524NASFunctionATP binding
3551GO:0005737NASComponentcytoplasm
3551GO:0006468IEAProcessprotein amino acid phosphorylation
3551GO:0006468NASProcessprotein amino acid phosphorylation
3551GO:0016563NASFunctiontranscriptional activator activity
3551GO:0016740IEAFunctiontransferase activity
3551GO:0051092IDAProcessactivation of NF-kappaB transcription factor
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-8518NP_003631.1inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated proteinHPRD04763
-8837NP_003870.3CASP8 and FADD-like apoptosis regulatorHPRD04671
-10010NP_004171.2TRAF interacting protein TANK isoform aHPRD04870
-8202NP_006525.1nuclear receptor coactivator 3HPRD03570
-7186NP_066961.2TNF receptor-associated factor 2HPRD03538
-10758NP_671733.1TRAF3 interacting protein 2 isoform 1HPRD06129
NP_001547.1--MEKK1HPRD04462
NP_001547.1--TRPC4APHPRD04462
NP_001547.18518-IKAPHPRD04462
NP_001547.15610-PKRHPRD04462
NP_001547.110758-C6ORF5 proteinHPRD04462
NP_001547.18837-c-FLIPHPRD04462
NP_001547.17186-TRAF2HPRD04462
NP_001547.18202-NCOA3HPRD04462
NP_001547.110010-I-TRAFHPRD04462
NP_001547.13576NC_000004.9Homo sapiens chromosome 4BIND182679
NP_001547.17132NP_001056.1tumor necrosis factor receptor 1 precursorHPRD04462
NP_001547.17132NP_001056.1tumor necrosis factor receptor 1 precursorHPRD01861
NP_001547.13551NP_001547.1inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase betaBIND178827
NP_001547.14296NP_002410.1mitogen-activated protein kinase kinase kinase 11HPRD04462
NP_001547.14296NP_002410.1mitogen-activated protein kinase kinase kinase 11HPRD02502
NP_001547.14793NP_002494.2nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta isoform aBIND178831
NP_001547.18517NP_003630.1inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gammaHPRD02217
NP_001547.18517NP_003630.1inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gammaHPRD04462
NP_001547.18517NP_003630.1inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gammaBIND209043
NP_001547.18518NP_003631.2inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated proteinBIND182487
NP_001547.19020NP_003945.1mitogen-activated protein kinase kinase kinase 14HPRD04462
NP_001547.19020NP_003945.1mitogen-activated protein kinase kinase kinase 14HPRD05230
NP_001547.19020NP_003945.1mitogen-activated protein kinase kinase kinase 14BIND178826
NP_001547.14790NP_003989.1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)HPRD04462
NP_001547.14790NP_003989.1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)HPRD01238
NP_001547.19175NP_004712.1mitogen-activated protein kinase kinase kinase 13HPRD05372
NP_001547.19175NP_004712.1mitogen-activated protein kinase kinase kinase 13HPRD04462
NP_001547.17278NP_005992.1tubulin, alpha 2 isoform 1HPRD03958
NP_001547.15588NP_006248.1protein kinase C, thetaHPRD02710
NP_001547.15588NP_006248.1protein kinase C, thetaHPRD04462
NP_001547.15588NP_006248.1protein kinase C, thetaBIND209042
NP_001547.17128NP_006281.1tumor necrosis factor, alpha-induced protein 3HPRD01857
NP_001547.17128NP_006281.1tumor necrosis factor, alpha-induced protein 3HPRD04462
NP_001547.111140NP_008996.1CDC37 homologBIND193137
NP_001547.14792NP_065390.1nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alphaBIND178825
NP_001547.14792NP_065390.1nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alphaBIND130506
NP_001547.14792NP_065390.1nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alphaBIND259370
NP_001547.1347733NP_821080.1tubulin, beta polypeptide paralogHPRD14707
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3551IKKB_HUMANO14920IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
3551IKKB_HUMANO14920IPR000719Prot_kinaseProtein kinase
3551IKKB_HUMANO14920IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
3551IKKB_HUMANO14920IPR001245Tyr_pkinaseTyrosine protein kinase
3551IKKB_HUMANO14920IPR000626UbiquitinUbiquitin
3551IKKB_HUMANO14920IPR013695WAKWall-associated kinase

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