Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3554
Official Symbol:IL1R1
Other Aliases:CD121A|D2S1473|IL-1R-alpha|IL1R|IL1RA|P80
See related:HGNC:5993|MIM:147810|HPRD:00994
Chromosome:2
Location:2q12
Gene Description:interleukin 1 receptor, type I
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0357
ORGANISM:human
Entrez Gene ID:3554
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Upregulated
Fold Change:0.58
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
16177CBCerebellum3.974167585372924.89604806900024
16177CTXCerebral cortex1.262191176414491.33635640144348
16177HIPHippocampal region20.370647430419939.1991004943848
16177HPFHippocampal formation16.098012924194329.4092464447021
16177HYHypothalamus0.7503339052200320.978026390075684
16177LSXLateral septal complex0.3351390957832340.243132427334785
16177MBMidbrain1.596918225288392.4126672744751
16177MYMedulla2.888829708099373.04540276527405
16177OLFOlfactory bulb0.9600324034690861.08023369312286
16177PPons1.978543162345892.74625658988953
16177PALPallidum1.044519782066351.0234295129776
16177RHPRetrohippocampal region7.5064201354980513.6981077194214
16177sAMYStriatum-like amygdalar nuclei0.6457497477531431.17869412899017
16177STRStriatum1.129382252693181.42141497135162
16177STRdStriatum dorsal region1.005195736885071.33877861499786
16177STRvStriatum ventral region2.070670127868652.07372140884399
16177THThalamus2.490512609481813.05634617805481
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3554GO:0004888TASFunctiontransmembrane receptor activity
3554GO:0004909TASFunctioninterleukin-1, Type I, activating receptor activity
3554GO:0005515IPIFunctionprotein binding
3554GO:0005887TASComponentintegral to plasma membrane
3554GO:0006954NRProcessinflammatory response
3554GO:0007166TASProcesscell surface receptor linked signal transduction
3554GO:0016020IEAComponentmembrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-59307NP_068577.1single Ig IL-1R-related moleculeHPRD12018
NP_000868.15295-Phosphatidylinositol 3 kinase regulatory subunit, alphaHPRD00994
NP_000868.13557NP_000568.1interleukin 1 receptor antagonist isoform 3HPRD00994
NP_000868.13557NP_000568.1interleukin 1 receptor antagonist isoform 3HPRD00978
NP_000868.13656NP_001561.2interleukin-1 receptor-associated kinase 2HPRD00994
NP_000868.13656NP_001561.2interleukin-1 receptor-associated kinase 2HPRD04491
NP_000868.13556NP_002173.1interleukin 1 receptor accessory protein isoform 1HPRD00994
NP_000868.13556NP_002173.1interleukin 1 receptor accessory protein isoform 1HPRD04021
NP_000868.1353376NP_067681.1toll-like receptor adaptor molecule 2HPRD16313
NP_000868.1353376NP_067681.1toll-like receptor adaptor molecule 2BIND180467
NP_000868.184639NP_115945.4interleukin 1 family, member 10HPRD17144
NP_000868.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3554IL1R1_HUMANP14778IPR013591DZCDisease resistance/zinc finger/chromosome condensation-like region
3554IL1R1_HUMANP14778IPR007110Ig-likeImmunoglobulin-like
3554IL1R1_HUMANP14778IPR004076IL1R_rcptInterleukin-1 receptor IL1R
3554IL1R1_HUMANP14778IPR004075IL1_rcpt_1Interleukin-1 receptor, type I/Toll precursor
3554IL1R1_HUMANP14778IPR004074IL1_rcpt_I/IIInterleukin-1 receptor, type I and type II
3554IL1R1_HUMANP14778IPR013151ImmunoglobulinImmunoglobulin
3554IL1R1_HUMANP14778IPR013568SEFIRSEFIR
3554IL1R1_HUMANP14778IPR000157TIRToll-Interleukin receptor

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