Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:356
Official Symbol:FASLG
Other Aliases:APT1LG1|CD178|CD95L|FASL|TNFSF6
See related:HGNC:11936|MIM:134638|HPRD:00610
Chromosome:1
Location:1q23
Gene Description:Fas ligand (TNF superfamily, member 6)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:QTL0022
ORGANISM:human
Entrez Gene ID:356
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14103CBCerebellum2.416949748992923.30305051803589
14103CTXCerebral cortex0.7126439809799190.824531495571136
14103HIPHippocampal region1.337149381637572.1595025062561
14103HPFHippocampal formation1.459892868995672.1638617515564
14103HYHypothalamus1.850310325622564.00807237625122
14103LSXLateral septal complex0.06493856757879260.0711682289838791
14103MBMidbrain0.8170233964920042.05279564857483
14103MYMedulla1.697044372558592.55750942230225
14103OLFOlfactory bulb6.145218849182137.03464603424072
14103PPons2.900997400283817.2781229019165
14103PALPallidum1.303053736686713.61267495155334
14103RHPRetrohippocampal region1.24689352512361.20968878269196
14103sAMYStriatum-like amygdalar nuclei1.365140080451971.27886176109314
14103STRStriatum1.684836030006411.91871988773346
14103STRdStriatum dorsal region0.179936379194260.196408703923225
14103STRvStriatum ventral region7.674250602722178.11732292175293
14103THThalamus0.2397880554199220.248253390192986
KARG Evidence 2
KARG ID:QTL0022
Trait:activity response to ethanol
Peak:85
Peak Marker:NA
Parents:(DBA/2J x C57BL/6J)F2 intercross
Evidence ID:11529277
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
356GO:0005164IEAFunctiontumor necrosis factor receptor binding
356GO:0005615IEAComponentextracellular space
356GO:0005887TASComponentintegral to plasma membrane
356GO:0006915IEAProcessapoptosis
356GO:0006917TASProcessinduction of apoptosis
356GO:0006955IEAProcessimmune response
356GO:0007165TASProcesssignal transduction
356GO:0007267TASProcesscell-cell signaling
356GO:0016020IEAComponentmembrane
356GO:0043123IEPProcesspositive regulation of I-kappaB kinase/NF-kappaB cascade
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-55660AAH27178.1PRPF40A proteinHPRD10995
-4687NP_000256.1neutrophil cytosolic factor 1HPRD01990
-1616NP_001341.1death-associated protein 6HPRD04424
-2335NP_002017.1fibronectin 1 isoform 3 preproproteinHPRD00626
-2534NP_002028.1protein-tyrosine kinase fyn isoform aHPRD00655
-7341NP_003343.1SMT3 suppressor of mif two 3 homolog 1 isoform a precursorHPRD03554
-7430NP_003370.2villin 2HPRD00475
-1756NP_003997.1dystrophin Dp427m isoformHPRD02303
-9402NP_004801.1GRB2-related adaptor protein 2HPRD05156
-3932NP_005347.2lymphocyte-specific protein tyrosine kinaseHPRD01080
-6714NP_005408.1proto-oncogene tyrosine-protein kinase SRCHPRD01819
-4297NP_005924.1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)HPRD01162
-4690NP_006144.1NCK adaptor protein 1HPRD02740
-10750NP_006604.1GRB2-related adaptor proteinHPRD05062
-11252NP_009160.1protein kinase C and casein kinase substrate in neurons 2HPRD05390
NC_000001.81959NP_000390.2early growth response 2 proteinBIND258816
NC_000001.81960NP_004421.2early growth response 3BIND258817
NP_000630.1--Ess1HPRD00610
NP_000630.1--FBP11HPRD00610
NP_000630.1--FBP17HPRD00610
NP_000630.12534-FynHPRD00610
NP_000630.17341-SUMO1HPRD00610
NP_000630.11616-DaxxHPRD00610
NP_000630.17430-EzrinHPRD00610
NP_000630.12335-Fibronectin 1HPRD00610
NP_000630.110750-GRB2 related adaptor proteinHPRD00610
NP_000630.11756-DystrophinHPRD00610
NP_000630.13932-LckHPRD00610
NP_000630.14687-p47-phoxHPRD00610
NP_000630.14690-NCK1HPRD00610
NP_000630.15295-Phosphatidylinositol 3 kinase regulatory subunit, alphaHPRD00610
NP_000630.16714-c-SrcHPRD00610
NP_000630.19402-GRIDHPRD00610
NP_000630.111252-PACSIN2HPRD00610
NP_000630.14297-MLLHPRD00610
NP_000630.123048AAK49824.1Homo sapiens formin-binding protein 17 (FBP17) mRNA, partial cds.BIND183688
NP_000630.12885NP_002077.1growth factor receptor-bound protein 2 isoform 1HPRD00150
NP_000630.12885NP_002077.1growth factor receptor-bound protein 2 isoform 1HPRD00610
NP_000630.12885NP_002077.1growth factor receptor-bound protein 2 isoform 1BIND183671
NP_000630.14316NP_002414.1matrix metalloproteinase 7 preproproteinHPRD00610
NP_000630.14316NP_002414.1matrix metalloproteinase 7 preproproteinHPRD01525
NP_000630.111252NP_009160.1protein kinase C and casein kinase substrate in neurons 2BIND183691
NP_000630.110016NP_037364.1programmed cell death 6HPRD03035
NP_000630.110016NP_037364.1programmed cell death 6HPRD00610
NP_000630.123048NP_055848.1formin binding protein 1HPRD10446
NP_000630.18771NP_116563.1tumor necrosis factor receptor superfamily, member 6bHPRD04527
NP_000630.18771NP_116563.1tumor necrosis factor receptor superfamily, member 6bHPRD00610
NP_000630.15783NP_542416.1protein tyrosine phosphatase, non-receptor type 13 isoform 4HPRD02602
NP_000630.15783NP_542416.1protein tyrosine phosphatase, non-receptor type 13 isoform 4HPRD00610
NP_000630.123048Q96RU3Formin-binding protein 17.HPRD00610
NP_000630.1155871NP_057853.1Tat--
NP_000630.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
356TNFL6_HUMANP48023IPR008064Fas_ligandFas ligand
356TNFL6_HUMANP48023IPR006030Mollsc_rhodpsn_CMolluscan rhodopsin C-terminal tail
356TNFL6_HUMANP48023IPR000108Neu_cyt_fact_2Neutrophil cytosol factor 2
356TNFL6_HUMANP48023IPR003882Pistil_extensinPistil-specific extensin-like protein
356TNFL6_HUMANP48023IPR000694PRO_richProline-rich region
356TNFL6_HUMANP48023IPR006053TNF_abcTumor necrosis factor alpha, beta and c
356TNFL6_HUMANP48023IPR002961TNF_CTumour necrosis factor c/lymphotoxin-beta
356TNFL6_HUMANP48023IPR006052TNF_familyTumor Necrosis Factor
356TNFL6_HUMANP48023IPR006077Vinculin/cateninVinculin/alpha-catenin

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