Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:3570
Official Symbol:IL6R
Other Aliases:CD126|IL-6R-1|IL-6R-alpha|IL6RA|MGC104991
See related:HGNC:6019|MIM:147880|HPRD:01000
Chromosome:1
Location:1q21
Gene Description:interleukin 6 receptor
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0545
ORGANISM:human
Entrez Gene ID:3570
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:24499
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
16194CBCerebellum2.936562776565553.6171658039093
16194CTXCerebral cortex4.863864421844483.53525018692017
16194HIPHippocampal region5.05054855346684.40289068222046
16194HPFHippocampal formation6.78240680694585.5925145149231
16194HYHypothalamus6.181588649749765.17584896087646
16194LSXLateral septal complex0.2075107842683790.280544221401215
16194MBMidbrain3.507972478866583.68296098709106
16194MYMedulla6.381470203399667.21270847320557
16194OLFOlfactory bulb10.97474575042728.94757556915283
16194PPons3.189256191253663.80406618118286
16194PALPallidum2.291235446929931.7105495929718
16194RHPRetrohippocampal region9.425634384155277.0518946647644
16194sAMYStriatum-like amygdalar nuclei0.7503758072853090.706701874732971
16194STRStriatum2.286466121673581.52420496940613
16194STRdStriatum dorsal region2.644438266754151.77252840995789
16194STRvStriatum ventral region2.47715115547181.51421666145325
16194THThalamus2.81299400329592.27180504798889
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
3570GO:0004872IEAFunctionreceptor activity
3570GO:0004896IEAFunctionhematopoietin/interferon-class (D200-domain) cytokine receptor activity
3570GO:0004915TASFunctioninterleukin-6 receptor activity
3570GO:0005576IDAComponentextracellular region
3570GO:0005896TASComponentinterleukin-6 receptor complex
3570GO:0006955TASProcessimmune response
3570GO:0007166TASProcesscell surface receptor linked signal transduction
3570GO:0007275TASProcessdevelopment
3570GO:0008283TASProcesscell proliferation
3570GO:0016020IEAComponentmembrane
3570GO:0019899IPIFunctionenzyme binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-3572NP_002175.1interleukin 6 signal transducer (gp130, oncostatin M receptor)HPRD02824
-3572NP_002175.1interleukin 6 signal transducer (gp130, oncostatin M receptor)HPRD02824
-6714NP_005408.1proto-oncogene tyrosine-protein kinase SRCHPRD01819
-6774NP_644805.1signal transducer and activator of transcription 3 isoform 1HPRD00026
-6774NP_644805.1signal transducer and activator of transcription 3 isoform 1HPRD00026
NP_000556.13572-Interleukin 6 receptor, betaHPRD01000
NP_000556.16714-c-SrcHPRD01000
NP_000556.16774-STAT3HPRD01000
NP_000556.19223NP_004733.1BAI1-associated protein 1HPRD01000
NP_000556.111059NP_008944.1WW domain containing E3 ubiquitin protein ligase 1HPRD01000
NP_000556.111060NP_008945.1Nedd-4-like ubiquitin-protein ligaseHPRD01000
NP_000556.111060NP_008945.1Nedd-4-like ubiquitin-protein ligaseHPRD03812
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
3570IPR002996Cytkn_rcpt_B/GCytokine receptor, common beta/gamma chain
3570IPR003961FN_IIIFibronectin, type III
3570IPR003530Hempt_rcpt_L_F3Long hematopoietin receptor, soluble alpha chain
3570IPR007110Ig-likeImmunoglobulin-like
3570IPR013151ImmunoglobulinImmunoglobulin
3570IPR013106V-setImmunoglobulin V-set
3570IL6RA_HUMANP08887IPR002996Cytkn_rcpt_B/GCytokine receptor, common beta/gamma chain
3570IL6RA_HUMANP08887IPR003961FN_IIIFibronectin, type III
3570IL6RA_HUMANP08887IPR003530Hempt_rcpt_L_F3Long hematopoietin receptor, soluble alpha chain
3570IL6RA_HUMANP08887IPR007110Ig-likeImmunoglobulin-like
3570IL6RA_HUMANP08887IPR013151ImmunoglobulinImmunoglobulin
3570IL6RA_HUMANP08887IPR013106V-setImmunoglobulin V-set
3570IL6RA_HUMANP08887IPR000628Vprs_rcpt_V1BVasopressin VIB receptor

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